Mechanisms for the prevention of vitamin E excess

Urinary α-carboxyethyl hydroxychroman can be used as a predictor of α-tocopherol adequacy, as demonstrated in the Energetics Study

(2012) Katie M Lebold et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Novel metabolites and roles for α-tocopherol in humans and mice discovered by mass spectrometry–based metabolomics1–5

(2012) Caroline H Johnson et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Comparison of the intestinal absorption and bioavailability of γ-tocotrienol and α-tocopherol: in vitro, in situ and in vivo studies

(2012) Bilal S. Abuasal et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Cholesterol Efflux and Atheroprotection

(2012) Robert S. Rosenson et al.   CIRCULATION

Expression of the α-tocopherol transfer protein gene is regulated by oxidative stress and common single-nucleotide polymorphisms

(2012) Lynn Ulatowski et al.   FREE RADICAL BIOLOGY AND MEDICINE

Disturbed ratio of renal 20-HETE/EETs is involved in androgen-induced hypertension in cytochrome P450 4F2 transgenic mice

(2012) Xiaoliang Liu et al.   GENE

Disruption of Mouse Cytochrome P450 4f14 (Cyp4f14Gene) Causes Severe Perturbations in Vitamin E Metabolism

(2012) Sabrina A. Bardowell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Disruption of P450-mediated vitamin E hydroxylase activities alters vitamin E status in tocopherol supplemented mice and reveals extra-hepatic vitamin E metabolism

(2012) Sabrina A. Bardowell et al.   JOURNAL OF LIPID RESEARCH

Genome-Wide Association Study Identifies Three Common Variants Associated with Serologic Response to Vitamin E Supplementation in Men

(2012) Jacqueline M. Major et al.   JOURNAL OF NUTRITION

This Kinetic, Bioavailability, and Metabolism Study of RRR-α-Tocopherol in Healthy Adults Suggests Lower Intake Requirements than Previous Estimates

(2012) Janet A. Novotny et al.   JOURNAL OF NUTRITION

Tissue Distribution of Vitamin E Metabolites in Rats after Oral Administration of Tocopherol or Tocotrienol

(2012) Tomono UCHIDA et al.   JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY

Enhancement of Intestinal Permeability Utilizing Solid Lipid Nanoparticles Increases γ-Tocotrienol Oral Bioavailability

(2012) Bilal S. Abuasal et al.   LIPIDS

Vitamin E decreases extra-hepatic menaquinone-4 concentrations in rats fed menadione or phylloquinone

(2012) Sherry M. Farley et al.   MOLECULAR NUTRITION & FOOD RESEARCH

The impact of phospholipid transfer protein (PLTP) on lipoprotein metabolism

(2012) Xian-Cheng Jiang et al.   Nutrition & Metabolism

Alpha-tocotrienol is the most abundant tocotrienol isomer circulated in plasma and lipoproteins after postprandial tocotrienol-rich vitamin E supplementation

(2012) Syed Fairus et al.   Nutrition Journal

The functional variant V433M of the CYP4F2 and the metabolic syndrome in Swedes

(2012) Cristiano Fava et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Enzymatic Sulfation of Tocopherols and Tocopherol Metabolites by Human Cytosolic Sulfotransferases

(2011) Takuyu HASHIGUCHI et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Respective contributions of intestinal Niemann-Pick C1-like 1 and scavenger receptor class B type I to cholesterol and tocopherol uptake: in vivo v. in vitro studies

(2011) Emmanuelle Reboul et al.   BRITISH JOURNAL OF NUTRITION

Role of superoxide radical anion in the mechanism of apoB100 degradation induced by DHA in hepatic cells

(2011) Ursula Andreo et al.   FASEB JOURNAL

α-Tocopherol injections in rats up-regulate hepatic ABC transporters, but not cytochrome P450 enzymes

(2011) Maret G. Traber et al.   FREE RADICAL BIOLOGY AND MEDICINE

Genome-wide association study identifies common variants associated with circulating vitamin E levels

(2011) Jacqueline M. Major et al.   HUMAN MOLECULAR GENETICS

Quantitation of [5-CH3]-(2R, 4'R, 8'R)-α-Tocopherol in Humans

(2011) Jennifer C. Chuang et al.   JOURNAL OF NUTRITION

Tissue Distribution of α- and γ-Tocotrienol and γ-Tocopherol in Rats and Interference with Their Accumulation by α-Tocopherol

(2011) Tomono Uchida et al.   LIPIDS

Association of 1347 G/A cytochrome P450 4F2 (CYP4F2) gene variant with hypertension and stroke

(2011) Anjana Munshi et al.   MOLECULAR BIOLOGY REPORTS

Plasma Phospholipid Transfer Protein Deficiency in Mice Is Associated With a Reduced Thrombotic Response to Acute Intravascular Oxidative Stress

(2010) Catherine Desrumaux et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Hepatic α-Tocopherol Transfer Protein: Ligand-Induced Protection from Proteasomal Degradation

(2010) Varsha Thakur et al.   BIOCHEMISTRY

Intestinal Absorption of  -Tocotrienol Is Mediated by Niemann-Pick C1-Like 1: In Situ Rat Intestinal Perfusion Studies

(2010) B. Abuasal et al.   DRUG METABOLISM AND DISPOSITION

Analysis of Multiple Metabolites of Tocopherols and Tocotrienols in Mice and Humans

(2010) Yang Zhao et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

The Contribution of Surface Residues to Membrane Binding and Ligand Transfer by the α-Tocopherol Transfer Protein (α-TTP)

(2010) Wen Xiao Zhang et al.   JOURNAL OF MOLECULAR BIOLOGY

Common Variants of Cytochrome P450 4F2 Exhibit Altered Vitamin E-ω-Hydroxylase Specific Activity

(2010) Sabrina A. Bardowell et al.   JOURNAL OF NUTRITION

A novel method for the direct measurement of urinary conjugated metabolites of α-tocopherol and its use in diabetes

(2010) Gayatri Sharma et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Identification of UBIAD1 as a novel human menaquinone-4 biosynthetic enzyme

(2010) Kimie Nakagawa et al.   NATURE

Ataxia with vitamin E deficiency: update of molecular diagnosis

(2010) I. Di Donato et al.   NEUROLOGICAL SCIENCES

Association of common variants of CYP4A11 and CYP4F2 with stroke in the Han Chinese population

(2010) Hu Ding et al.   Pharmacogenetics and Genomics

CYP4F2 gene V433M polymorphism is associated with ischemic stroke in the male Northern Chinese Han population

(2010) Shumin Deng et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Optimization of the enzymatic hydrolysis and analysis of plasma conjugated γ-CEHC and sulfated long-chain carboxychromanols, metabolites of vitamin E

(2009) Helene Freiser et al.   ANALYTICAL BIOCHEMISTRY

Bayesian model averaging in meta-analysis: vitamin E supplementation and mortality

(2009) Donald Berry et al.   Clinical Trials

α-tocopherol β-oxidation localized to rat liver mitochondria

(2009) Debbie J. Mustacich et al.   FREE RADICAL BIOLOGY AND MEDICINE

Vitamin E Supplementation and Hepatic Drug Metabolism in Humans

(2009) Michael W Clarke et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Metabolomics reveals a novel vitamin E metabolite and attenuated vitamin E metabolism upon PXR activation

(2009) Joo-Youn Cho et al.   JOURNAL OF LIPID RESEARCH

γ-Tocotrienol and γ-Tocopherol Are Primarily Metabolized to Conjugated 2-(β-carboxyethyl)-6-Hydroxy-2,7,8-Trimethylchroman and Sulfated Long-Chain Carboxychromanols in Rats

(2009) Helene Freiser et al.   JOURNAL OF NUTRITION

ATP-Binding cassette transporter A1 is involved in hepatic α-tocopherol secretion

(2009) Mototada Shichiri et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Effect of Bilayer Phospholipid Composition and Curvature on Ligand Transfer by the α-Tocopherol Transfer Protein

(2009) Wen Xiao Zhang et al.   LIPIDS

CYP4F2 Is a Vitamin K1 Oxidase: An Explanation for Altered Warfarin Dose in Carriers of the V433M Variant

(2009) M. G. McDonald et al.   MOLECULAR PHARMACOLOGY

Biosynthesis, regulation and functions of tocochromanols in plants

(2009) Laurent Mène-Saffrané et al.   PLANT PHYSIOLOGY AND BIOCHEMISTRY

ATP-binding cassette transporter A1 is significantly involved in the intestinal absorption of α- and γ-tocopherol but not in that of retinyl palmitate in mice

(2008) Emmanuelle Reboul et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Cytochrome P450 omega hydroxylase (CYP4) function in fatty acid metabolism and metabolic diseases

(2008) James P. Hardwick   BIOCHEMICAL PHARMACOLOGY

Inhibition of oxidative metabolism of tocopherols with ω-N-heterocyclic derivatives of vitamin E

(2008) Stephan Ohnmacht et al.   BIOORGANIC & MEDICINAL CHEMISTRY

CYP4F2 genetic variant alters required warfarin dose

(2008) M. D. Caldwell et al.   BLOOD

Human fasting plasma concentrations of vitamin E and carotenoids, and their association with genetic variants in apo C-III, cholesteryl ester transfer protein, hepatic lipase, intestinal fatty acid binding protein and microsomal triacylglycerol transfer protein

(2008) Patrick Borel et al.   BRITISH JOURNAL OF NUTRITION

Isolation and Identification of α-CEHC Sulfate in Rat Urine and an Improved Method for the Determination of Conjugated α-CEHC

(2008) Yi-Jen Li et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Mechanisms of Ligand Transfer by the Hepatic Tocopherol Transfer Protein

(2008) Samantha Morley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alpha-tocopherol modulates genes involved in hepatic xenobiotic pathways in mice

(2008) Debbie J. Mustacich et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Association of a Functional Cytochrome P450 4F2 Haplotype with Urinary 20-HETE and Hypertension

(2008) H. Liu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Vitamin E Transfer from Lipid Emulsions to Plasma Lipoproteins: Mediation by Multiple Mechanisms

(2008) M. Hacquebard et al.   LIPIDS

Niemann-Pick C1-Like 1 Mediates  -Tocopherol Transport

(2008) K. Narushima et al.   MOLECULAR PHARMACOLOGY