PI3K/AKT/p53 pathway inhibits infectious spleen and kidney necrosis virus infection by regulating autophagy and immune responses

Inhibition of PI3K/Akt/mTOR pathway by ammonium chloride induced apoptosis and autophagy in MAC-T cell

(2021) Luping Feng et al.   RESEARCH IN VETERINARY SCIENCE

Low-dose naltrexone plays antineoplastic role in cervical cancer progression through suppressing PI3K/AKT/mTOR pathway

(2021) Ning Liu et al.   Translational Oncology

Akt Inhibition Is Associated With Favorable Immune Profile Changes Within the Tumor Microenvironment of Hormone Receptor Positive, HER2 Negative Breast Cancer

(2020) Douglas K. Marks et al.   Frontiers in Oncology

SNORD126 Promotes Hepatitis C Virus Infection by Upregulating Claudin-1 via Activation of PI3K-AKT Signaling Pathway

(2020) Xijing Qian et al.   Frontiers in Microbiology

mTOR inhibitor Everolimus-induced apoptosis in melanoma cells

(2019) Dorota Ciołczyk-Wierzbicka et al.   Journal of Cell Communication and Signaling

In vitro and in vivo Induction of p53-Dependent Apoptosis by Extract of Euryale ferox Salisb in A549 Human Caucasian Lung Carcinoma Cancer Cells Is Mediated Through Akt Signaling Pathway

(2019) Gun-He Nam et al.   Frontiers in Oncology

LC3-positive structures are prominent in autophagy-deficient cells

(2019) Gautam Runwal et al.   Scientific Reports

Inhibition of PI3K/Akt/mTOR pathway by apigenin induces apoptosis and autophagy in hepatocellular carcinoma cells

(2018) Jiali Yang et al.   BIOMEDICINE & PHARMACOTHERAPY

PI3K signaling pathways modulated white spot syndrome virus (WSSV) replication in Procambarus clarkii

(2018) Huijing Zhang et al.   FISH & SHELLFISH IMMUNOLOGY

The infection of red seabream iridovirus in mandarin fish ( Siniperca chuatsi ) and the host immune related gene expression profiles

(2018) Xiaodan Liu et al.   FISH & SHELLFISH IMMUNOLOGY

Development of cross-priming amplification coupled with vertical flow visualization for rapid detection of infectious spleen and kidney necrosis virus (ISKNV) in mandarin fish, Siniperca chuatsi

(2018) Wenzhi Liu et al.   JOURNAL OF VIROLOGICAL METHODS

Various stress stimuli rewire the profile of liver secretome in a p53-dependent manner

(2018) Meital Charni-Natan et al.   Cell Death & Disease

ROS-induced HSP70 promotes cytoplasmic translocation of high-mobility group box 1b and stimulates antiviral autophagy in grass carp kidney cells

(2018) Youliang Rao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Disentangling the role of PI3K/Akt, Rho GTPase and the actin cytoskeleton on dengue virus infection

(2018) Alexandra Milena Cuartas-López et al.   VIRUS RESEARCH

Sinomenine inhibits the growth of melanoma by enhancement of autophagy via PI3K/AKT/mTOR inhibition

(2018) Zheng Sun et al.   Drug Design Development and Therapy

Marek’s Disease Virus Activates the PI3K/Akt Pathway Through Interaction of Its Protein Meq With the P85 Subunit of PI3K to Promote Viral Replication

(2018) Huimin Li et al.   Frontiers in Microbiology

Autophagy promoted infectious kidney and spleen necrosis virus replication and decreased infectious virus yields in CPB cell line

(2017) Chen Li et al.   FISH & SHELLFISH IMMUNOLOGY

The PI3K/Akt/mTOR pathway is involved in CVB3-induced autophagy of HeLa cells

(2017) Huan Chang et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

PI3K/AKT/mTOR pathway promotes progestin resistance in endometrial cancer cells by inhibition of autophagy

(2017) Hua Liu et al.   OncoTargets and Therapy

Transient activation of the PI3K/Akt pathway promotes Newcastle disease virus replication and enhances anti-apoptotic signaling responses

(2017) Yinfeng Kang et al.   Oncotarget

An essential role of PI3K in the control of West Nile virus infection

(2017) Leilei Wang et al.   Scientific Reports

The PI3K/AKT Pathway as a Target for Cancer Treatment

(2016) Ingrid A. Mayer et al.   Annual Review of Medicine

AKT-p53 axis protect cancer cells from autophagic cell death during nutrition deprivation

(2016) S. Sudhagar et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Suppression of Virulent Porcine Epidemic Diarrhea Virus Proliferation by the PI3K/Akt/GSK-3α/β Pathway

(2016) Ning Kong et al.   PLoS One

Sulforaphane Suppresses Hepatitis C Virus Replication by Up-Regulating Heme Oxygenase-1 Expression through PI3K/Nrf2 Pathway

(2016) Jung-Sheng Yu et al.   PLoS One

Drugging PI3K in cancer: refining targets and therapeutic strategies

(2015) Timothy A Yap et al.   CURRENT OPINION IN PHARMACOLOGY

To complete its replication cycle, a shrimp virus changes the population of long chain fatty acids during infection via the PI3K-Akt-mTOR-HIF1α pathway

(2015) Yun-Chieh Hsieh et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Transcriptomic analysis of Mandarin fish brain cells infected with infectious spleen and kidney necrosis virus with an emphasis on retinoic acid-inducible gene 1-like receptors and apoptosis pathways

(2015) Xianqin Hu et al.   FISH & SHELLFISH IMMUNOLOGY

PI3King the Lock

(2015) David King et al.   JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY

A novel fish cell line derived from the brain of Chinese perchSiniperca chuatsi: development and characterization

(2014) X. Fu et al.   JOURNAL OF FISH BIOLOGY

Dual Regulatory Roles of Phosphatidylinositol 3-Kinase in IFN Signaling

(2014) S. Kaur et al.   JOURNAL OF IMMUNOLOGY

The Hepatitis B Virus (HBV) HBx Protein Activates AKT To Simultaneously Regulate HBV Replication and Hepatocyte Survival

(2014) Siddhartha Rawat et al.   JOURNAL OF VIROLOGY

PI3K and cancer: lessons, challenges and opportunities

(2014) David A. Fruman et al.   NATURE REVIEWS DRUG DISCOVERY

miR-19b promotes tumor growth and metastasis via targeting TP53

(2014) Y. Fan et al.   RNA

Epidermal Growth Factor Receptor-PI3K Signaling Controls Cofilin Activity To Facilitate Herpes Simplex Virus 1 Entry into Neuronal Cells

(2014) K. Zheng et al.   mBio

An Invertebrate Warburg Effect: A Shrimp Virus Achieves Successful Replication by Altering the Host Metabolome via the PI3K-Akt-mTOR Pathway

(2014) Mei-An Su et al.   PLoS Pathogens

HSV activates Akt to trigger calcium release and promote viral entry: novel candidate target for treatment and suppression

(2013) Natalia Cheshenko et al.   FASEB JOURNAL

mTOR inhibitors in cancer therapy

(2012) Yekaterina Y. Zaytseva et al.   CANCER LETTERS

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

HBx induces HepG-2 cells autophagy through PI3K/Akt–mTOR pathway

(2012) Peng Wang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

The translational landscape of mTOR signalling steers cancer initiation and metastasis

(2012) Andrew C. Hsieh et al.   NATURE

Nitazoxanide Stimulates Autophagy and Inhibits mTORC1 Signaling and Intracellular Proliferation of Mycobacterium tuberculosis

(2012) Karen K. Y. Lam et al.   PLoS Pathogens

The PI3K, Metabolic, and Autophagy Networks: Interactive Partners in Cellular Health and Disease

(2011) Naval P. Shanware et al.   Annual Review of Pharmacology and Toxicology

The interplay between Araçatuba virus and host signaling pathways: role of PI3K/Akt in viral replication

(2011) Marcelo H. A. de Freitas et al.   ARCHIVES OF VIROLOGY

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Infectious Spleen and Kidney Necrosis Virus (a Fish Iridovirus) Enters Mandarin Fish Fry Cells via Caveola-Dependent Endocytosis

(2011) C.-J. Guo et al.   JOURNAL OF VIROLOGY

Phosphoinositide-3 Kinase-Akt Pathway Controls Cellular Entry of Ebola Virus

(2011) Mohammad F. Saeed et al.   PLoS Pathogens

Herpes Simplex Virus is Akt-ing in translational control

(2010) K. L. Norman et al.   GENES & DEVELOPMENT

Energy metabolism in adult neural stem cell fate

(2010) Victoria A. Rafalski et al.   PROGRESS IN NEUROBIOLOGY

Activation of PI 3-kinase/Akt/NF-κB and Stat3 signaling by avian reovirus S1133 in the early stages of infection results in an inflammatory response and delayed apoptosis

(2010) Ping-Yuan Lin et al.   VIROLOGY

Phosphatidylinositol 3-Kinase Regulates Macrophage Responses to Double-Stranded RNA and Encephalomyocarditis Virus

(2009) Wieke Freudenburg et al.   Journal of Innate Immunity

Role of the Akt pathway in mRNA translation of interferon-stimulated genes

(2008) S. Kaur et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA