Human and mouse muscle transcriptomic analyses identify insulin receptor mRNA downregulation in hyperinsulinemia‐associated insulin resistance

Temporal Associations Among Body Mass Index, Fasting Insulin, and Systemic Inflammation

(2021) Natasha Wiebe et al.   JAMA Network Open

Physiological responses to maximal eating in men

(2020) Aaron Hengist et al.   BRITISH JOURNAL OF NUTRITION

Molecular Transducers of Human Skeletal Muscle Remodeling under Different Loading States

(2020) Tanner Stokes et al.   Cell Reports

Muscle-Specific Insulin Receptor Overexpression Protects Mice From Diet-Induced Glucose Intolerance but Leads to Postreceptor Insulin Resistance

(2020) Guoxiao Wang et al.   DIABETES

Multi-dimensional Transcriptional Remodeling by Physiological Insulin In Vivo

(2019) Thiago M. Batista et al.   Cell Reports

Iatrogenic Hyperinsulinemia, Not Hyperglycemia, Drives Insulin Resistance in Type 1 Diabetes as Revealed by Comparison to GCK-MODY (MODY2)

(2019) Justin M. Gregory et al.   DIABETES

NetworkAnalyst 3.0: a visual analytics platform for comprehensive gene expression profiling and meta-analysis

(2019) Guangyan Zhou et al.   NUCLEIC ACIDS RESEARCH

Integrative analysis of gene expression, DNA methylation, physiological traits, and genetic variation in human skeletal muscle

(2019) D. Leland Taylor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of hyperinsulinaemia in apparently healthy non-obese young adults: role of insulin secretion, clearance and action and associations with plasma amino acids

(2019) Steven Hamley et al.   DIABETOLOGIA

Early Time-Restricted Feeding Improves Insulin Sensitivity, Blood Pressure, and Oxidative Stress Even without Weight Loss in Men with Prediabetes

(2018) Elizabeth F. Sutton et al.   Cell Metabolism

Reducing insulin via conditional partial gene ablation in adults reverses diet-induced weight gain

(2018) Melissa M. Page et al.   FASEB JOURNAL

A coding and non-coding transcriptomic perspective on the genomics of human metabolic disease

(2018) James A Timmons et al.   NUCLEIC ACIDS RESEARCH

Mild Suppression of Hyperinsulinemia to Treat Obesity and Insulin Resistance

(2018) Melissa M. Page et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

A brief introduction to mixed effects modelling and multi-model inference in ecology

(2018) Xavier A. Harrison et al.   PeerJ

A causal role for hyperinsulinemia in obesity

(2017) Nicole M Templeman et al.   JOURNAL OF ENDOCRINOLOGY

Altered gene expression and repressed markers of autophagy in skeletal muscle of insulin resistant patients with type 2 diabetes

(2017) Andreas Buch Møller et al.   Scientific Reports

Reduced Circulating Insulin Enhances Insulin Sensitivity in Old Mice and Extends Lifespan

(2017) Nicole M. Templeman et al.   Cell Reports

Characterization of dFOXO binding sites upstream of the Insulin Receptor P2 promoter across the Drosophila phylogeny

(2017) Dorcas J. Orengo et al.   PLoS One

ReactomePA: an R/Bioconductor package for reactome pathway analysis and visualization

(2016) Guangchuang Yu et al.   Molecular BioSystems

iGEMS: an integrated model for identification of alternative exon usage events

(2016) Sanjana Sood et al.   NUCLEIC ACIDS RESEARCH

MARCH1 regulates insulin sensitivity by controlling cell surface insulin receptor levels

(2016) Arvindhan Nagarajan et al.   Nature Communications

Fitting Linear Mixed-Effects Models Usinglme4

(2015) Douglas Bates et al.   Journal of Statistical Software

Comparison of a carbohydrate-free diet vs. fasting on plasma glucose, insulin and glucagon in type 2 diabetes

(2015) Frank Q. Nuttall et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Insulin promotes vascular smooth muscle cell proliferation and apoptosis via differential regulation of tumor necrosis factor-related apoptosis-inducing ligand

(2015) Hanis H. Harith et al.   Journal of Diabetes

Identification of suitable reference genes for quantitative RT-PCR during 3T3-L1 adipocyte differentiation

(2014) JUAN ZHANG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Exposure to excess insulin (glargine) induces type 2 diabetes mellitus in mice fed on a chow diet

(2014) Xuefeng Yang et al.   JOURNAL OF ENDOCRINOLOGY

Insulin Receptor Signaling in Normal and Insulin-Resistant States

(2014) J. Boucher et al.   Cold Spring Harbor Perspectives in Biology

NUCKS Is a Positive Transcriptional Regulator of Insulin Signaling

(2014) Beiying Qiu et al.   Cell Reports

Iterative rank-order normalization of gene expression microarray data

(2013) Eric A Welsh et al.   BMC BIOINFORMATICS

Sin3: Insight into its transcription regulatory functions

(2013) Rama Kadamb et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

LMBD1 Protein Serves as a Specific Adaptor for Insulin Receptor Internalization

(2013) Linda Tzu-Ling Tseng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Hyperinsulinemia Drives Diet-Induced Obesity Independently of Brain Insulin Production

(2012) Arya E. Mehran et al.   Cell Metabolism

Basal state hyperinsulinemia in healthy normoglycemic adults heralds dysglycemia after more than two decades of follow up

(2012) R. Dankner et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

(2012) Guangchuang Yu et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Function-Based Discovery of Significant Transcriptional Temporal Patterns in Insulin Stimulated Muscle Cells

(2012) Barbara Di Camillo et al.   PLoS One

High Insulin Concentrations Repress Insulin Receptor Gene Expression in Calf Hepatocytes Cultured in Vitro

(2011) Zhigang Zhang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Banting Lecture 2011: Hyperinsulinemia: Cause or Consequence?

(2011) B. E. Corkey   DIABETES

Hyperinsulinemia Induces Insulin Resistance in Dorsal Root Ganglion Neurons

(2011) Bhumsoo Kim et al.   ENDOCRINOLOGY

The opposing transcriptional functions of Sin3a and c-Myc are required to maintain tissue homeostasis

(2011) Elisabete M. Nascimento et al.   NATURE CELL BIOLOGY

GLUT4 and UBC9 Protein Expression Is Reduced in Muscle from Type 2 Diabetic Patients with Severe Insulin Resistance

(2011) Ulla Kampmann et al.   PLoS One

Nature of fatty acids in high fat diets differentially delineates obesity-linked metabolic syndrome components in male and female C57BL/6J mice

(2011) Souhad El Akoum et al.   Diabetology & Metabolic Syndrome

Early phase insulin secretion is increased in subjects with normal fasting glucose and metabolic syndrome: a premature feature of beta-cell dysfunction

(2010) L. Spadaro et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Increased basal level of Akt-dependent insulin signaling may be responsible for the development of insulin resistance

(2009) Hui-Yu Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

From the Triumvirate to the Ominous Octet: A New Paradigm for the Treatment of Type 2 Diabetes Mellitus

(2009) R. A. DeFronzo   DIABETES

Insulin-Like Growth Factor Type 1 Receptor and Insulin Receptor Isoform Expression and Signaling in Mammary Epithelial Cells

(2009) Anne M. Rowzee et al.   ENDOCRINOLOGY

Central Insulin Signaling Is Attenuated by Long-Term Insulin Exposure via Insulin Receptor Substrate-1 Serine Phosphorylation, Proteasomal Degradation, and Lysosomal Insulin Receptor Degradation

(2009) Christopher M. Mayer et al.   ENDOCRINOLOGY

Insulin Is a Stronger Inducer of Insulin Resistance than Hyperglycemia in Mice with Type 1 Diabetes Mellitus (T1DM)

(2009) Hui-Yu Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gene Expression in Skeletal Muscle Biopsies from People with Type 2 Diabetes and Relatives: Differential Regulation of Insulin Signaling Pathways

(2009) Jane Palsgaard et al.   PLoS One

Alterations of insulin signaling in type 2 diabetes: A review of the current evidence from humans

(2008) Sara Fröjdö et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Insulin Resistance and Hyperinsulinemia: Is hyperinsulinemia the cart or the horse?

(2008) M. H. Shanik et al.   DIABETES CARE

Insulin Regulates Glucagon-Like Peptide-1 Secretion from the Enteroendocrine L Cell

(2008) Gareth E. Lim et al.   ENDOCRINOLOGY