A causal role for hyperinsulinemia in obesity

Metabolic activity of brown, “beige,” and white adipose tissues in response to chronic adrenergic stimulation in male mice

(2016) Sébastien M. Labbé et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Reduced Insulin Production Relieves Endoplasmic Reticulum Stress and Induces β Cell Proliferation

(2016) Marta Szabat et al.   Cell Metabolism

Fasting, Circadian Rhythms, and Time-Restricted Feeding in Healthy Lifespan

(2016) Valter D. Longo et al.   Cell Metabolism

The Adipose Tissue Microenvironment Regulates Depot-Specific Adipogenesis in Obesity

(2016) Elise Jeffery et al.   Cell Metabolism

Brown Adipose Tissue Activation Is Linked to Distinct Systemic Effects on Lipid Metabolism in Humans

(2016) Maria Chondronikola et al.   Cell Metabolism

Lipodystrophy Due to Adipose Tissue–Specific Insulin Receptor Knockout Results in Progressive NAFLD

(2016) Samir Softic et al.   DIABETES

Caloric Restriction Paradoxically Increases Adiposity in Mice With Genetically Reduced Insulin

(2016) Derek A. Dionne et al.   ENDOCRINOLOGY

Diazoxide in Children With Obesity After Hypothalamic-Pituitary Lesions: A Randomized, Placebo-Controlled Trial

(2016) Raja Brauner et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Chronic hyperinsulinemia reduces insulin sensitivity and metabolic functions of brown adipocyte

(2016) Sujith Rajan et al.   JOURNAL OF ENDOCRINOLOGY

Initial hyperinsulinemia and subsequent β-cell dysfunction is associated with elevated palmitate levels

(2016) Johan Staaf et al.   PEDIATRIC RESEARCH

Inter-domain tagging implicates caveolin-1 in insulin receptor trafficking and Erk signaling bias in pancreatic beta-cells

(2016) Tobias Boothe et al.   Molecular Metabolism

Insulin in the nervous system and the mind: Functions in metabolism, memory, and mood

(2016) Seung-Hwan Lee et al.   Molecular Metabolism

Hyper-Variability in Circulating Insulin, High Fat Feeding Outcomes, and Effects of Reducing Ins2 Dosage in Male Ins1-Null Mice in a Specific Pathogen-Free Facility

(2016) Nicole M. Templeman et al.   PLoS One

Insulin Resistance as a Physiological Defense Against Metabolic Stress: Implications for the Management of Subsets of Type 2 Diabetes

(2015) Christopher J. Nolan et al.   DIABETES

Suppression of hyperinsulinaemia in growing female mice provides long-term protection against obesity

(2015) Nicole M. Templeman et al.   DIABETOLOGIA

Genomic medicine at the heart of diabetes management

(2015) Mark I. McCarthy   DIABETOLOGIA

Pulsatile insulin secretion, impaired glucose tolerance and type 2 diabetes

(2015) Leslie S. Satin et al.   MOLECULAR ASPECTS OF MEDICINE

14-3-3ζ coordinates adipogenesis of visceral fat

(2015) Gareth E. Lim et al.   Nature Communications

The Sex Determination Gene transformer Regulates Male-Female Differences in Drosophila Body Size

(2015) Elizabeth J. Rideout et al.   PLoS Genetics

A major role of insulin in promoting obesity-associated adipose tissue inflammation

(2015) David J. Pedersen et al.   Molecular Metabolism

Association between carbohydrate quality and inflammatory markers: systematic review of observational and interventional studies

(2014) Anette E Buyken et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Ins1 Cre knock-in mice for beta cell-specific gene recombination

(2014) Bernard Thorens et al.   DIABETOLOGIA

Insulin-like peptide 5 is an orexigenic gastrointestinal hormone

(2014) J. Grosse et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Origins and Drivers of Insulin Resistance

(2013) Andrew M.F. Johnson et al.   CELL

Weighing in on Adipocyte Precursors

(2013) Ryan Berry et al.   Cell Metabolism

Insulin signalling mechanisms for triacylglycerol storage

(2013) M. P. Czech et al.   DIABETOLOGIA

Daily physical activity predicts degree of insulin resistance: a cross-sectional observational study using the 2003–2004 National Health and Nutrition Examination Survey

(2013) Rachael K Nelson et al.   International Journal of Behavioral Nutrition and Physical Activity

Is Dynamic Autocrine Insulin Signaling Possible? A Mathematical Model Predicts Picomolar Concentrations of Extracellular Monomeric Insulin within Human Pancreatic Islets

(2013) Minghu Wang et al.   PLoS One

Intensive insulin for type 2 diabetes: the risk of causing harm

(2013) Christopher J Nolan et al.   Lancet Diabetes & Endocrinology

Sex differences in adipose tissue

(2013) Esther Fuente-Martín et al.   Adipocyte

In vitro brown and “brite”/“beige” adipogenesis: Human cellular models and molecular aspects

(2012) Guillaume E. Beranger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Hyperinsulinemia Drives Diet-Induced Obesity Independently of Brain Insulin Production

(2012) Arya E. Mehran et al.   Cell Metabolism

Time-Restricted Feeding without Reducing Caloric Intake Prevents Metabolic Diseases in Mice Fed a High-Fat Diet

(2012) Megumi Hatori et al.   Cell Metabolism

Low-carbohydrate ketogenic diets, glucose homeostasis, and nonalcoholic fatty liver disease

(2012) Rebecca C. Schugar et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Maintenance of  -Cell Maturity and Plasticity in the Adult Pancreas: Developmental Biology Concepts in Adult Physiology

(2012) M. Szabat et al.   DIABETES

Adipose tissue heterogeneity: Implication of depot differences in adipose tissue for obesity complications

(2012) Mi-Jeong Lee et al.   MOLECULAR ASPECTS OF MEDICINE

The many faces of insulin-like peptide signalling in the brain

(2012) Ana M. Fernandez et al.   NATURE REVIEWS NEUROSCIENCE

Basal Insulin and Cardiovascular and Other Outcomes in Dysglycemia

(2012)   NEW ENGLAND JOURNAL OF MEDICINE

Impaired thermogenesis and adipose tissue development in mice with fat-specific disruption of insulin and IGF-1 signalling

(2012) Jeremie Boucher et al.   Nature Communications

Banting Lecture 2011: Hyperinsulinemia: Cause or Consequence?

(2011) B. E. Corkey   DIABETES

Nucleo-cytosolic Shuttling of FoxO1 Directly Regulates MouseIns2but NotIns1Gene Expression in Pancreatic Beta Cells (MIN6)

(2011) Gargi Meur et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Type 2 diabetes across generations: from pathophysiology to prevention and management

(2011) Christopher J Nolan et al.   LANCET

Metabolite profiles and the risk of developing diabetes

(2011) Thomas J Wang et al.   NATURE MEDICINE

Glucolipotoxicity age-dependently impairs beta cell function in rats despite a marked increase in beta cell mass

(2010) G. Fontés et al.   DIABETOLOGIA

Hyperinsulinemia Precedes Insulin Resistance in Mice Lacking Pancreatic β-Cell Leptin Signaling

(2010) Sarah L. Gray et al.   ENDOCRINOLOGY

Extending Healthy Life Span--From Yeast to Humans

(2010) L. Fontana et al.   SCIENCE

Insulin signaling meets mitochondria in metabolism

(2010) Zhiyong Cheng et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Basal-State Hyperinsulinemia in Healthy Normoglycemic Adults Is Predictive of Type 2 Diabetes Over a 24-Year Follow-Up: A preliminary report

(2009) R. Dankner et al.   DIABETES CARE

Thymus-specific deletion of insulin induces autoimmune diabetes

(2009) Yong Fan et al.   EMBO JOURNAL

Trajectories of glycaemia, insulin sensitivity, and insulin secretion before diagnosis of type 2 diabetes: an analysis from the Whitehall II study

(2009) Adam G Tabák et al.   LANCET

Insulin Signaling in the Pancreatic β-Cell

(2008) Ingo B. Leibiger et al.   Annual Review of Nutrition

Physical Activity and Insulin Sensitivity: The RISC Study

(2008) B. Balkau et al.   DIABETES

Glucose Metabolism In Vivo in Four Commonly Used Inbred Mouse Strains

(2008) E. D. Berglund et al.   DIABETES

Insulin Resistance and Hyperinsulinemia: Is hyperinsulinemia the cart or the horse?

(2008) M. H. Shanik et al.   DIABETES CARE

Insulin Stimulates Primary β-Cell Proliferation via Raf-1 Kinase

(2008) Jennifer L. Beith et al.   ENDOCRINOLOGY

Adaptive Evolution of the Insulin Two-Gene System in Mouse

(2008) M.-S. Shiao et al.   GENETICS

Carboxypeptidase E mediates palmitate-induced  -cell ER stress and apoptosis

(2008) K. D. Jeffrey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Similarities and differences between insulin and IGF-I: Structures, receptors, and signalling pathways

(2008) Haim Werner et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY