Overcoming roadblocks in the development of vaccines for leishmaniasis

How COVID unlocked the power of RNA vaccines

(2021) Elie Dolgin   NATURE

Characterization of a new Leishmania major strain for use in a controlled human infection model

(2021) Helen Ashwin et al.   Nature Communications

Predicting recognition between T cell receptors and epitopes with TCRGP

(2021) Emmi Jokinen et al.   PLoS Computational Biology

Localized skin inflammation during cutaneous leishmaniasis drives a chronic, systemic IFN-γ signature

(2021) Camila Farias Amorim et al.   PLoS Neglected Tropical Diseases

An invariant Trypanosoma vivax vaccine antigen induces protective immunity

(2021) Delphine Autheman et al.   NATURE

Messenger RNA expressing PfCSP induces functional, protective immune responses against malaria in mice

(2021) Katherine L. Mallory et al.   npj Vaccines

Preclinical validation of a live attenuated dermotropic Leishmania vaccine against vector transmitted fatal visceral leishmaniasis

(2021) Subir Karmakar et al.   Communications Biology

Vaccines against leishmaniasis: using controlled human infection models to accelerate development

(2021) Vivak Parkash et al.   Expert Review of Vaccines

Quantitative evaluation of PpSP15-LmSTI1 fusion gene expression following transfection with an alphavirus-derived self-amplifying mRNA and conventional DNA vaccine platforms

(2021) Nastaran Sadat Savar et al.   MOLECULAR AND CELLULAR PROBES

Human genetics of leishmania infections

(2020) Jenefer M. Blackwell et al.   HUMAN GENETICS

Commercially approved vaccines for canine leishmaniosis: a review of available data on their safety and efficacy

(2020) Rita Velez et al.   TROPICAL MEDICINE & INTERNATIONAL HEALTH

Current Affairs of Microbial Genome-Wide Association Studies: Approaches, Bottlenecks and Analytical Pitfalls

(2020) James Emmanuel San et al.   Frontiers in Microbiology

Socioeconomic, demographic and landscape factors associated with cutaneous leishmaniasis in Kurunegala District, Sri Lanka

(2020) Tharaka Wijerathna et al.   Parasites & Vectors

Leishmaniasis immunopathology—impact on design and use of vaccines, diagnostics and drugs

(2020) Paul M. Kaye et al.   Seminars in Immunopathology

In Vitro Generation of Leishmania Hybrids

(2020) Isabelle Louradour et al.   Cell Reports

Genomic analysis of natural intra-specific hybrids among Ethiopian isolates of Leishmania donovani

(2020) James A. Cotton et al.   PLoS Neglected Tropical Diseases

Host transcriptomic signature as alternative test-of-cure in visceral leishmaniasis patients co-infected with HIV

(2020) Wim Adriaensen et al.   EBioMedicine

Leishmania lipophosphoglycan components: A potent target for synthetic neoglycoproteins as a vaccine candidate for leishmaniasis

(2020) Aiman Saleh A. Mohammed et al.   CARBOHYDRATE POLYMERS

The balancing act: Immunology of leishmaniosis

(2020) Angela J. Toepp et al.   RESEARCH IN VETERINARY SCIENCE

A second generation leishmanization vaccine with a markerless attenuated Leishmania major strain using CRISPR gene editing

(2020) Wen-Wei Zhang et al.   Nature Communications

A spatio-temporal approach to short-term prediction of visceral leishmaniasis diagnoses in India

(2020) Emily S. Nightingale et al.   PLoS Neglected Tropical Diseases

The potential impact of human visceral leishmaniasis vaccines on population incidence

(2020) Epke A. Le Rutte et al.   PLoS Neglected Tropical Diseases

Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

(2020) Theo Vos et al.   LANCET

Ecological divergence and hybridization of Neotropical Leishmania parasites

(2020) Frederik Van den Broeck et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inferring transmission trees to guide targeting of interventions against visceral leishmaniasis and post–kala-azar dermal leishmaniasis

(2020) Lloyd A. C. Chapman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Challenges of Developing Novel Vaccines With Particular Global Health Importance

(2020) Penny M. Heaton   Frontiers in Immunology

Cutaneous leishmaniasis and co-morbid major depressive disorder: A systematic review with burden estimates

(2019) Freddie Bailey et al.   PLoS Neglected Tropical Diseases

Spatio-temporal modelling of Leishmania infantum infection among domestic dogs: a simulation study and sensitivity analysis applied to rural Brazil

(2019) Elizabeth Buckingham-Jeffery et al.   Parasites & Vectors

Leishmania and its exosomal pathway: a novel direction for vaccine development

(2019) Martin Olivier et al.   Future Microbiology

“Running the Gauntlet”: Formidable challenges in advancing neglected tropical diseases vaccines from development through licensure, and a “Call to Action”

(2019) Maria Elena Bottazzi et al.   Human Vaccines & Immunotherapeutics

The impact of leishmaniasis on mental health and psychosocial well-being: A systematic review

(2019) Malini Pires et al.   PLoS One

Vaccines for leishmaniasis and the implications of their development for American tegumentary leishmaniasis

(2019) Beatriz Coutinho De Oliveira et al.   Human Vaccines & Immunotherapeutics

Bayesian compartmental models and associated reproductive numbers for an infection with multiple transmission modes

(2019) Marie V. Ozanne et al.   BIOMETRICS

Visceral Leishmaniasis and HIV Co-Infection in Northwest Ethiopia: Antiretroviral Treatment and Burden of Disease among Patients Enrolled in HIV Care

(2018) Johan van Griensven et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Gut Microbes Egested during Bites of Infected Sand Flies Augment Severity of Leishmaniasis via Inflammasome-Derived IL-1β

(2018) Ranadhir Dey et al.   Cell Host & Microbe

Policy Recommendations From Transmission Modeling for the Elimination of Visceral Leishmaniasis in the Indian Subcontinent

(2018) Epke A Le Rutte et al.   CLINICAL INFECTIOUS DISEASES

Epitope-Binding Characteristics for Risk versus Protective DRB1 Alleles for Visceral Leishmaniasis

(2018) Toolika Singh et al.   JOURNAL OF IMMUNOLOGY

Recent Development of Visceral Leishmaniasis Treatments: Successes, Pitfalls, and Perspectives

(2018) Fabiana Alves et al.   CLINICAL MICROBIOLOGY REVIEWS

A Leishmania infantum genetic marker associated with miltefosine treatment failure for visceral leishmaniasis

(2018) Juliana B.T. Carnielli et al.   EBioMedicine

Understanding the economic impact of leishmaniasis on households in endemic countries: a systematic review

(2018) Temmy Sunyoto et al.   Expert Review of Anti-Infective Therapy

Economic Analysis of Vaccination Programs: An ISPOR Good Practices for Outcomes Research Task Force Report

(2018) Josephine Mauskopf et al.   VALUE IN HEALTH

Visceral leishmaniasis: Spatiotemporal heterogeneity and drivers underlying the hotspots in Muzaffarpur, Bihar, India

(2018) Caroline A. Bulstra et al.   PLoS Neglected Tropical Diseases

Cost of visceral leishmaniasis care in Brazil

(2017) Isis Polianna Silva Ferreira de Carvalho et al.   TROPICAL MEDICINE & INTERNATIONAL HEALTH

Gene Expression in Leishmania Is Regulated Predominantly by Gene Dosage

(2017) Stefano A. Iantorno et al.   mBio

A third generation vaccine for human visceral leishmaniasis and post kala azar dermal leishmaniasis: First-in-human trial of ChAd63-KH

(2017) Mohamed Osman et al.   PLoS Neglected Tropical Diseases

A defined subunit vaccine that protects against vector-borne visceral leishmaniasis

(2017) Malcolm S. Duthie et al.   npj Vaccines

Developmental differentiation in Leishmania lifecycle progression: post-transcriptional control conducts the orchestra

(2016) LM De Pablos et al.   CURRENT OPINION IN MICROBIOLOGY

The challenges on developing vaccine against visceral leishmaniasis

(2016) Selma Maria Bezerra Jerônimo et al.   Revista da Sociedade Brasileira de Medicina Tropical

Status of vaccine research and development of vaccines for leishmaniasis

(2016) Portia M. Gillespie et al.   VACCINE

Country-Level Cost-Effectiveness Thresholds: Initial Estimates and the Need for Further Research

(2016) Beth Woods et al.   VALUE IN HEALTH

Meta-transcriptome Profiling of the Human-Leishmania braziliensis Cutaneous Lesion

(2016) Stephen M. Christensen et al.   PLoS Neglected Tropical Diseases

Post-Genomics and Vaccine Improvement for Leishmania

(2016) Negar Seyed et al.   Frontiers in Microbiology

Leishmania vaccine development: exploiting the host–vector–parasite interface

(2015) SG Reed et al.   Expert Review of Vaccines

Quantitative analyses and modelling to support achievement of the 2020 goals for nine neglected tropical diseases

(2015) T. Déirdre Hollingsworth et al.   Parasites & Vectors

Uniting mathematics and biology for control of visceral leishmaniasis

(2015) Kat S. Rock et al.   TRENDS IN PARASITOLOGY

Challenges and responses in human vaccine development

(2014) Stefan HE Kaufmann et al.   CURRENT OPINION IN IMMUNOLOGY

Cross-species genetic exchange between visceral and cutaneous strains ofLeishmaniain the sand fly vector

(2014) Audrey Romano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ANIMAL MODELS FOR THE STUDY OF LEISHMANIASIS IMMUNOLOGY

(2014) Elsy Nalleli Loria-Cervera et al.   REVISTA DO INSTITUTO DE MEDICINA TROPICAL DE SAO PAULO

Modular Multiantigen T Cell Epitope-Enriched DNA Vaccine Against Human Leishmaniasis

(2014) S. Das et al.   Science Translational Medicine

The Economic Burden of Visceral Leishmaniasis in Sudan: An Assessment of Provider and Household Costs

(2013) Filip Meheus et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Report of the Post Kala-Azar Dermal Leishmaniasis (PKDL) consortium meeting, New Delhi, India, 27–29 June 2012

(2013) Philippe Desjeux et al.   Parasites & Vectors

Case study for a vaccine against leishmaniasis

(2013) Jorge Alvar et al.   VACCINE

The Malnutrition-Related Increase in Early Visceralization of Leishmania donovani Is Associated with a Reduced Number of Lymph Node Phagocytes and Altered Conduit System Flow

(2013) Marwa K. Ibrahim et al.   PLoS Neglected Tropical Diseases

The Economic Value of a Visceral Leishmaniasis Vaccine in Bihar State, India

(2012) Bruce Y. Lee et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Therapeutic Vaccination With Recombinant Adenovirus Reduces Splenic Parasite Burden in Experimental Visceral Leishmaniasis

(2012) A. Maroof et al.   JOURNAL OF INFECTIOUS DISEASES

Leishmaniasis Worldwide and Global Estimates of Its Incidence

(2012) Jorge Alvar et al.   PLoS One

Cost-effectiveness and economic benefits of vaccines in low- and middle-income countries: A systematic review

(2012) Sachiko Ozawa et al.   VACCINE

Leishmaniasis: complexity at the host–pathogen interface

(2011) Paul Kaye et al.   NATURE REVIEWS MICROBIOLOGY

The development and clinical evaluation of second-generation leishmaniasis vaccines

(2011) Malcolm S. Duthie et al.   VACCINE

Vaccines for the Leishmaniases: Proposals for a Research Agenda

(2011) et al.   PLoS Neglected Tropical Diseases

Visceral Leishmaniasis in the Indian Subcontinent: Modelling Epidemiology and Control

(2011) Anette Stauch et al.   PLoS Neglected Tropical Diseases

Estimation of Under-Reporting of Visceral Leishmaniasis Cases in Bihar, India

(2010) Vijay P. Singh et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Learning from failure

(2010)   NATURE REVIEWS DRUG DISCOVERY

Demonstration of Genetic Exchange During Cyclical Development of Leishmania in the Sand Fly Vector

(2009) N. S. Akopyants et al.   SCIENCE

Efficacy of killed whole-parasite vaccines in the prevention of leishmaniasis—A meta-analysis

(2009) Sassan Noazin et al.   VACCINE

Impact of transmission dynamics on the cost-effectiveness of rotavirus vaccination

(2009) Eunha Shim et al.   VACCINE

Vector Transmission of Leishmania Abrogates Vaccine-Induced Protective Immunity

(2009) Nathan C. Peters et al.   PLoS Pathogens

Immunity to a salivary protein of a sand fly vector protects against the fatal outcome of visceral leishmaniasis in a hamster model

(2008) R. Gomes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA