Senolytics and the compression of late-life mortality

Whole‐body senescent cell clearance alleviates age‐related brain inflammation and cognitive impairment in mice

(2021) Mikolaj Ogrodnik et al.   AGING CELL

The synergy of damage repair and retention promotes rejuvenation and prolongs healthy lifespans in cell lineages

(2020) Barbara Schnitzer et al.   PLoS Computational Biology

Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer’s disease model

(2019) Peisu Zhang et al.   NATURE NEUROSCIENCE

TGFβ2-induced senescence during early inner ear development

(2019) Alejandro Gibaja et al.   Scientific Reports

Stochastic modeling of aging cells reveals how damage accumulation, repair, and cell-division asymmetry affect clonal senescence and population fitness

(2019) Ruijie Song et al.   BMC BIOINFORMATICS

The role of cellular senescence in aging through the prism of Koch-like criteria

(2018) Hagai Yanai et al.   AGEING RESEARCH REVIEWS

Cellular senescence: Immunosurveillance and future immunotherapy

(2018) Dominick G.A. Burton et al.   AGEING RESEARCH REVIEWS

Senolytics improve physical function and increase lifespan in old age

(2018) Ming Xu et al.   NATURE MEDICINE

The generational scalability of single-cell replicative aging

(2018) Ping Liu et al.   Science Advances

Senescent fibroblasts drive ageing pigmentation: ​A potential therapeutic target for senile lentigo

(2018) Jung Eun Yoon et al.   Theranostics

Fisetin is a senotherapeutic that extends health and lifespan

(2018) Matthew J. Yousefzadeh et al.   EBioMedicine

Impaired immune surveillance accelerates accumulation of senescent cells and aging

(2018) Yossi Ovadya et al.   Nature Communications

The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration

(2017) Birgit Ritschka et al.   GENES & DEVELOPMENT

The Fountain of Youth by Targeting Senescent Cells?

(2017) Peter L.J. de Keizer   TRENDS IN MOLECULAR MEDICINE

Cellular senescence drives age-dependent hepatic steatosis

(2017) Mikolaj Ogrodnik et al.   Nature Communications

Senescent Carcinoma-Associated Fibroblasts Upregulate IL8 to Enhance Prometastatic Phenotypes

(2016) Tao Wang et al.   MOLECULAR CANCER RESEARCH

The temporal scaling of Caenorhabditis elegans ageing

(2016) Nicholas Stroustrup et al.   NATURE

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE

Cell Autonomous and Non-Autonomous Effects of Senescent Cells in the Skin

(2015) Marco Demaria et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Deciphering death: a commentary on Gompertz (1825) 'On the nature of the function expressive of the law of human mortality, and on a new mode of determining the value of life contingencies'

(2015) T. B. L. Kirkwood   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Recurrent turnover of senescent cells during regeneration of a complex structure

(2015) Maximina H Yun et al.   eLife

An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

(2014) Marco Demaria et al.   DEVELOPMENTAL CELL

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

A senescent cell bystander effect: senescence-induced senescence

(2012) Glyn Nelson et al.   AGING CELL

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

Senescence of Activated Stellate Cells Limits Liver Fibrosis

(2008) Valery Krizhanovsky et al.   CELL