The antipsychotic aripiprazole induces peripheral antinociceptive effects through PI3Kγ/NO/cGMP/K ATP pathway activation

Peripheral nitric oxide signaling directly blocks inflammatory pain

(2020) Francisco Isaac F. Gomes et al.   BIOCHEMICAL PHARMACOLOGY

Participation of the opioid receptor – nitric oxide – cGMP – K+ channel pathway in the peripheral antinociceptive effect of nalbuphine and buprenorphine in rats

(2020) Mario I. Ortiz et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

The PI3Kγ/AKT signaling pathway mediates peripheral antinociceptive action of dipyrone

(2020) Nerry T. Cecílio et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Peripheral antinociception induced by ketamine is mediated by the endogenous opioid system

(2019) Julia Alvarenga Petrocchi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Role of Endocannabinoid System in the Peripheral Antinociceptive Action of Aripiprazole

(2018) Renata C. M. Ferreira et al.   ANESTHESIA AND ANALGESIA

Untangling the complexity of opioid receptor function

(2018) Rita J. Valentino et al.   NEUROPSYCHOPHARMACOLOGY

The synthetic peptide PnPP-19 induces peripheral antinociception via activation of NO/cGMP/K ATP pathway: Role of eNOS and nNOS

(2017) A.C.N. Freitas et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Peripheral Antinociception Induced by Aripiprazole Is Mediated by the Opioid System

(2017) Renata Cristina Mendes Ferreira et al.   Biomed Research International

Salvia fruticosa Induces Vasorelaxation In Rat Isolated Thoracic Aorta: Role of the PI3K/Akt/eNOS/NO/cGMP Signaling Pathway

(2017) M. Akhtar Anwar et al.   Scientific Reports

Central antinociceptive effect of tapentadol is increased by nitric oxide synthase inhibitors

(2016) Magdalena Bujalska-Zadrożny et al.   BEHAVIOURAL PHARMACOLOGY

The antinociception of oxytocin on colonic hypersensitivity in rats was mediated by inhibition of mast cell degranulation via Ca2+-NOS pathway

(2016) Liping Gong et al.   Scientific Reports

FM19G11 reverses endothelial dysfunction in rat and human arteries through stimulation of the PI3K/Akt/eNOS pathway, independently of mTOR/HIF-1α activation

(2015) M El Assar et al.   BRITISH JOURNAL OF PHARMACOLOGY

Experimental design and analysis and their reporting: new guidance for publication in BJP

(2015) Michael J Curtis et al.   BRITISH JOURNAL OF PHARMACOLOGY

Implementing guidelines on reporting research using animals (ARRIVE etc.): new requirements for publication in BJP

(2015) John C McGrath et al.   BRITISH JOURNAL OF PHARMACOLOGY

The antipsychotic aripiprazole induces antinociceptive effects: Possible role of peripheral dopamine D2 and serotonin 5-HT1A receptors

(2015) Ana F. Almeida-Santos et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Tingenone, a pentacyclic triterpene, induces peripheral antinociception due to NO/cGMP and ATP-sensitive K+ channels pathway activation in mice

(2015) Clarice de Carvalho Veloso et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Aripiprazole for treating irritability in children & adolescents with autism: A systematic review

(2015) Ahmad Ghanizadeh et al.   INDIAN JOURNAL OF MEDICAL RESEARCH

Antinociceptive and anti-inflammatory effects of myricetin 3-O-β-galactoside isolated from Davilla elliptica: involvement of the nitrergic system

(2015) Adolfo de Oliveira Azevedo et al.   Journal of Natural Medicines

iNOS Activity Modulates Inflammation, Angiogenesis, and Tissue Fibrosis in Polyether-Polyurethane Synthetic Implants

(2015) Puebla Cassini-Vieira et al.   MEDIATORS OF INFLAMMATION

Small molecule inhibitors of PSD95-nNOS protein–protein interactions as novel analgesics

(2015) Wan-Hung Lee et al.   NEUROPHARMACOLOGY

Oxytocin-induced membrane hyperpolarization in pain-sensitive dorsal root ganglia neurons mediated by Ca2+/nNOS/NO/KATP pathway

(2015) L. Gong et al.   NEUROSCIENCE

Central release of nitric oxide mediates antinociception induced by aerobic exercise

(2015) G.S. Galdino et al.   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

Dopaminergic modulation of neuropathic pain: Analgesia in rats by a D2-type receptor agonist

(2014) Nuria Cobacho et al.   BRAIN RESEARCH BULLETIN

PI3Kγ integrates cAMP and Akt signalling of the μ-opioid receptor

(2014) Sreedhar Madishetti et al.   BRITISH JOURNAL OF PHARMACOLOGY

Aripiprazole: A Review of Its Use in the Treatment of Manic Episodes in Adolescents with Bipolar I Disorder

(2014) Kate McKeage   CNS DRUGS

The Nitric oxide/CGMP/KATP pathway mediates systemic and central antinociception induced by resistance exercise in rats

(2014) Giovane S. Galdino et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Ang-(1–7) activates the NO/cGMP and ATP-sensitive K+ channels pathway to induce peripheral antinociception in rats

(2013) Aline Costa et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Involvement of ATP‐sensitive K + channels in the peripheral antinociceptive effect induced by ketamine

(2013) Thiago RL Romero et al.   VETERINARY ANAESTHESIA AND ANALGESIA

Participation of cannabinoid receptors in peripheral nociception induced by some NSAIDs

(2012) L.C.R. Silva et al.   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

Aripiprazole

(2012) Jamie D. Croxtall   CNS DRUGS

N-Palmitoyl-ethanolamine (PEA) Induces Peripheral Antinociceptive Effect by ATP-Sensitive K+-Channel Activation

(2012) Thiago Roberto Lima Romero et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Probable involvement of Ca2+-activated Cl− channels (CaCCs) in the activation of CB1 cannabinoid receptors

(2012) Thiago Roberto Lima Romero et al.   LIFE SCIENCES

Stimulation of Peripheral Kappa Opioid Receptors Inhibits Inflammatory Hyperalgesia via Activation of the PI3Kγ/AKT/nNOS/NO Signaling Pathway

(2012) Thiago M Cunha et al.   Molecular Pain

Noradrenaline activates the NO/cGMP/ATP-sensitive K+ channels pathway to induce peripheral antinociception in rats

(2012) Thiago R.L. Romero et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Ketamine Activates the l-Arginine/Nitric Oxide/Cyclic Guanosine Monophosphate Pathway to Induce Peripheral Antinociception in Rats

(2011) Thiago R. L. Romero et al.   ANESTHESIA AND ANALGESIA

Pain and analgesia: The dual effect of nitric oxide in the nociceptive system

(2011) Yara Cury et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

The anandamide effect on NO/cGMP pathway in human platelets

(2010) Maria Grazia Signorello et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The Role of Nitric Oxide in the Local Antiallodynic and Antihyperalgesic Effects and Expression of  -Opioid and Cannabinoid-2 Receptors during Neuropathic Pain in Mice

(2010) A. Hervera et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

G-protein coupled receptor 35 (GPR35) activation and inflammatory pain: Studies on the antinociceptive effects of kynurenic acid and zaprinast

(2010) Cristina Cosi et al.   NEUROPHARMACOLOGY

Morphine peripheral analgesia depends on activation of the PI3K /AKT/nNOS/NO/KATP signaling pathway

(2010) T. M. Cunha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CONSORT 2010 Statement: Updated Guidelines for Reporting Parallel Group Randomised Trials

(2010) Kenneth F. Schulz et al.   PLOS MEDICINE

Probable involvement of α2C-adrenoceptor subtype and endogenous opioid peptides in the peripheral antinociceptive effect induced by xylazine

(2009) Thiago Roberto Lima Romero et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The peripheral administration of a nitric oxide donor potentiates the local antinociceptive effects of a DOR agonist during chronic inflammatory pain in mice

(2009) Arnau Hervera et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY