Divergent synthesis and biological evaluation of 2-(trifluoromethyl)pyridines as virulence-attenuating inverse agonists targeting PqsR

Hit Identification of New Potent PqsR Antagonists as Inhibitors of Quorum Sensing in Planktonic and Biofilm Grown Pseudomonas aeruginosa

(2020) Fadi Soukarieh et al.   Frontiers in Chemistry

Novel quinazolinone inhibitors of the Pseudomonas aeruginosa quorum sensing transcriptional regulator PqsR

(2020) Scott Grossman et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The symbiotic relationship between drug discovery and organic chemistry

(2019) Oleksandr O Grygorenko et al.   CHEMISTRY-A EUROPEAN JOURNAL

Flexible Fragment Growing Boosts Potency of Quorum‐Sensing Inhibitors against Pseudomonas aeruginosa Virulence

(2019) Michael Zender et al.   ChemMedChem

The challenge of converting Gram-positive-only compounds into broad-spectrum antibiotics

(2018) Michelle F. Richter et al.   Annals of the New York Academy of Sciences

Medicinal chemistry in drug discovery in big pharma: past, present and future

(2018) Ian B. Campbell et al.   DRUG DISCOVERY TODAY

Anti-biofilm effect of novel thiazole acid analogs against Pseudomonas aeruginosa through IQS pathways

(2018) Shengrong Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Pseudomonas aeruginosa Quorum Sensing Systems as Drug Discovery Targets: Current Position and Future Perspectives.

(2018) Fadi Soukarieh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Organic synthesis provides opportunities to transform drug discovery

(2018) David C. Blakemore et al.   Nature Chemistry

Targeting the Pseudomonas quinolone signal quorum sensing system for the discovery of novel anti-infective pathoblockers

(2018) Christian Schütz et al.   Beilstein Journal of Organic Chemistry

Predictive compound accumulation rules yield a broad-spectrum antibiotic

(2017) Michelle F. Richter et al.   NATURE

Structure–functionality relationship and pharmacological profiles of Pseudomonas aeruginosa alkylquinolone quorum sensing modulators

(2017) Ahmed A. M. Kamal et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

In-depth Profiling of MvfR-Regulated Small Molecules in Pseudomonas aeruginosa after Quorum Sensing Inhibitor Treatment

(2017) Giuseppe Allegretta et al.   Frontiers in Microbiology

The medicinal chemist's toolbox for late stage functionalization of drug-like molecules

(2016) Tim Cernak et al.   CHEMICAL SOCIETY REVIEWS

Novel Strategies for the Treatment of Pseudomonas aeruginosa Infections

(2016) Stefanie Wagner et al.   JOURNAL OF MEDICINAL CHEMISTRY

Challenges in managing Pseudomonas aeruginosa in non-cystic fibrosis bronchiectasis

(2016) Robert Wilson et al.   RESPIRATORY MEDICINE

Pseudomonas aeruginosa-Induced Bleb-Niche Formation in Epithelial Cells Is Independent of Actinomyosin Contraction and Enhanced by Loss of Cystic Fibrosis Transmembrane-Conductance Regulator Osmoregulatory Function

(2015) Amber L. Jolly et al.   mBio

Permeability Barrier of Gram-Negative Cell Envelopes and Approaches To Bypass It

(2015) Helen I. Zgurskaya et al.   ACS Infectious Diseases

The Evolving Role of Chemical Synthesis in Antibacterial Drug Discovery

(2014) Peter M. Wright et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Trends and Exceptions of Physical Properties on Antibacterial Activity for Gram-Positive and Gram-Negative Pathogens

(2014) Dean G. Brown et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification of Anti-virulence Compounds That Disrupt Quorum-Sensing Regulated Acute and Persistent Pathogenicity

(2014) Melissa Starkey et al.   PLoS Pathogens

Overcoming the Unexpected Functional Inversion of a PqsR Antagonist inPseudomonas aeruginosa: An In Vivo Potent Antivirulence Agent TargetingpqsQuorum Sensing

(2013) Cenbin Lu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Management of refractory Pseudomonas aeruginosa infection in cystic fibrosis

(2011) Roger Sorde et al.   Infection and Drug Resistance