PI3Kγδ inhibitor plus radiation enhances the antitumour immune effect of PD-1 blockade in syngenic murine breast cancer and humanised patient-derived xenograft model

Determining cell type abundance and expression from bulk tissues with digital cytometry

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PI3K isoforms in cell signalling and vesicle trafficking

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Human cord blood (hCB)-CD34+ humanized mice fail to reject human acute myeloid leukemia cells

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A translational concept of immuno-radiobiology

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Macrophage targeting: opening new possibilities for cancer immunotherapy

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Durable Complete Response After Discontinuation of Pembrolizumab in Patients With Metastatic Melanoma

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Atezolizumab for First-Line Treatment of Metastatic Nonsquamous NSCLC

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Targeting Myeloid-Derived Suppressor Cells to Bypass Tumor-Induced Immunosuppression

(2018) Viktor Fleming et al.   Frontiers in Immunology

Hyperprogressive disease: recognizing a novel pattern to improve patient management

(2018) Stéphane Champiat et al.   Nature Reviews Clinical Oncology

Time to abandon single-site irradiation for inducing abscopal effects

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Radiotherapy and immunotherapy: a beneficial liaison?

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Resistance to cancer immunotherapy mediated by apoptosis of tumor-infiltrating lymphocytes

(2017) Jingjing Zhu et al.   Nature Communications

DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity

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Immunotherapy resistance: the answers lie ahead – not in front – of us

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Radiotherapy combination opportunities leveraging immunity for the next oncology practice

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Hyperprogressive Disease Is a New Pattern of Progression in Cancer Patients Treated by Anti-PD-1/PD-L1

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Radiation Therapy Induces Macrophages to Suppress T-Cell Responses Against Pancreatic Tumors in Mice

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Overcoming resistance to checkpoint blockade therapy by targeting PI3Kγ in myeloid cells

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PI3Kγ is a molecular switch that controls immune suppression

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PI3K isoform-selective inhibitors: next-generation targeted cancer therapies

(2015) Xiang Wang et al.   ACTA PHARMACOLOGICA SINICA

The future of immune checkpoint therapy

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Systematic pan-cancer analysis of tumour purity

(2015) Dvir Aran et al.   Nature Communications

Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer

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PD-1 blockade induces responses by inhibiting adaptive immune resistance

(2014) Paul C. Tumeh et al.   NATURE

Tumor endothelium FasL establishes a selective immune barrier promoting tolerance in tumors

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Transient regulatory T cell ablation deters oncogene-driven breast cancer and enhances radiotherapy

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Fractionated but Not Single-Dose Radiotherapy Induces an Immune-Mediated Abscopal Effect when Combined with Anti-CTLA-4 Antibody

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