Article
Cell Biology
Wen-Xia Zheng, Wen-Qi He, Qian-Rui Zhang, Jin-Xin Jia, Sheng Zhao, Fang-Jian Wu, Xiao-Lu Cao
Summary: Baicalin can reduce the activity of the NLRP3 inflammasome through activation of the AMPK signaling pathway, thereby inhibiting cerebral ischemia-reperfusion injury.
Review
Biochemistry & Molecular Biology
Bercis Imge Ucar, Gulberk Ucar, Sarmistha Saha, Brigitta Buttari, Elisabetta Profumo, Luciano Saso
Summary: Ischemia/reperfusion (I/R) injury has significant clinical implications for various organs. Oxidative stress plays a critical role in I/R pathogenesis, and the Nrf2/HO-1 pathway could be a promising therapeutic strategy for preventing I/R injury.
Article
Integrative & Complementary Medicine
Haiyan Li, Dong-Hua Yang, Yanmei Zhang, Fuchun Zheng, Fenfei Gao, Jiajia Sun, Ganggang Shi
Summary: This study found that geniposide can significantly inhibit NLRP3 inflammasome activation via the AMPK signaling pathway and inhibit pyroptosis of cardiomyocytes. Geniposide has a cardioprotective effect, reducing myocardial infarction size, improving heart function, and suppressing inflammatory response. Additionally, geniposide promotes cellular energy metabolism and reduces oxidative stress levels.
Article
Plant Sciences
Meijuan Yin, Zhenyi Liu, Jing Wang, Weijuan Gao
Summary: The aim of this study was to investigate the molecular mechanism of Buyang Huanwu Decoction (BYHWD) in attenuating cerebral ischemia-reperfusion (I/R) oxidative damage by activating the PKC epsilon/Nrf2/HO-1 pathway. The results showed that BYHWD improved neural function, reduced neuronal damage, inhibited ROS production, decreased MDA and 8-OHdG levels, increased SOD and GSH-PX activity, and restored mitochondrial membrane potential. BYHWD activated the expression of Nrf2 and PKC epsilon, promoted Nrf2 translocation, and enhanced HO-1 expression. Therefore, BYHWD attenuates oxidative damage and reduces brain I/R injury by activating the PKC epsilon/Nrf2/HO-1 pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Cell Biology
Lin Zhuang, Wenbin Ding, Qi Zhang, Wei Ding, Xuezhong Xu, Xiaolong Yu, Dong Xi
Summary: The study revealed that TGR5 plays a crucial role in modulating hepatic ischemia/reperfusion injury by activating the Keap1-Nrf2 signaling pathway to alleviate inflammation response. The results showed that knockdown of TGR5 worsened hepatic tissue injury significantly, while treatment with a TGR5 agonist reversed this effect.
Article
Immunology
Kongwei Guo, Yanxing Shang, Zhao Wang, Yu Li, Jinliang Chen, Baofeng Zhu, Dongmei Zhang, Jianrong Chen
Summary: BRG1 plays a key role in apoptosis and oxidative damage, but its role in the pathophysiology of ischemic stroke is unclear. We found that BRG1 expression was increased during cerebral ischemia and reperfusion, particularly in activated microglia. Modulating BRG1 expression levels significantly affected microglial activation and the expression of antioxidant and pro-oxidant proteins after ischemic stroke. Our findings suggest that BRG1 protects against brain ischemia/reperfusion injury by reducing oxidative damage through the KEAP1-NRF2/HO-1 signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Yiqin Yao, Sheng Hu, Chunxue Zhang, Qun Zhou, Hui Wang, Ya Yang, Chao Liu, Haiyan Ding
Summary: Ginsenoside Rd exerts neuroprotective effects by inhibiting pyroptosis through the miR-139-5p/FoxO1/Keap1/Nrf2 axis in cerebral ischemia/reperfusion injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Yu Cui, Nan-Nan Zhang, Dan Wang, Wei-Hong Meng, Hui-Sheng Chen
Summary: This study is the first to report that MCP exerts neuroprotective effects in ischemic stroke through blocking galectin-3, which may be mediated by inhibiting the activation of NLRP3 inflammasome via TLR4/NF-Kappa B signaling pathway in microglia.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Neurosciences
Boru Hou, Donghai Li, Dengfeng Wang, Cheng Jiang, Gang Wang, Dong Wang, Guizhong Yan, Xiumei Guo, Lixia Zhao, Zhuangzhuang Wan, Chenlong Fan, Wencheng Cao, Haijun Ren
Summary: Ischemic stroke is a leading cause of disability and death worldwide. NLRP3 inflammasome, a complex of polyproteins, plays a role in inflammatory responses and is seen as a potential target for treating ischemic stroke. Vinpocetine, a derivative of vincamine, has been used for prevention and treatment of ischemic stroke, but its mechanism and effect on NLRP3 inflammasome are unclear.
Article
Environmental Sciences
Yang Yao, Rong Li, Dan Liu, Lihui Long, Na He
Summary: This study found that rosmarinic acid (RA) has a protective role against acetaminophen (APAP)-induced hepatotoxicity (AILI) by inhibiting ROS production and the NEK7-NLRP3 signaling pathway.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Review
Immunology
Tong Wu, Cheng Zhang, Tianfeng Shao, Jianzhong Chen, Diyu Chen
Summary: Ischemia-reperfusion injury (IRI) is a crucial factor in liver transplantation, and the activation of hepatic macrophages, especially NLRP3 inflammasome, plays a significant role in the progression of IRI. The NLRP3 inflammasome pathway in hepatic macrophages is highly expressed and may lead to liver IRI, making it a potential therapeutic target.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Medicinal
Yi Zhang, Mengmeng Liu, Yaoyuan Zhang, Mi Tian, Peng Chen, Yu Lan, Benhong Zhou
Summary: This study demonstrated that UA can alleviate oxidative stress and promote autophagy by activating the p62-Keap1-Nrf2 signaling pathway, which could protect the kidneys from ischemia reperfusion injury.
PHYTOTHERAPY RESEARCH
(2022)
Article
Plant Sciences
Qingwen Hu, Tianrui Zuo, Ling Deng, Sha Chen, Shengwei Liu, JingDong Liu, Xuan Wang, Xiaomei Fan, Zhi Dong
Summary: This study suggests that ferroptosis plays a critical role in the pathogenesis of acute ischemic stroke. β-Caryophyllene (BCP) has neuroprotective effects by regulating ferroptosis and activating the NRF2/HO-1 signaling pathway to improve cerebral ischemia injury.
Article
Immunology
Juanji Li, Pengfei Xu, Ye Hong, Yi Xie, Mengna Peng, Rui Sun, Hongquan Guo, Xiaohao Zhang, Wusheng Zhu, Junjun Wang, Xinfeng Liu
Summary: LCN2/24p3R mediates astrocyte pyroptosis via NLRP3 inflammasome activation following cerebral ischemia/reperfusion injury.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Plant Sciences
Fei Luan, Zhili Rao, Lixia Peng, Ziqin Lei, Jiuseng Zeng, Xi Peng, Ruocong Yang, Rong Liu, Nan Zeng
Summary: In this study, it was found that cinnamic acid (CA) has a protective effect on cardiomyocytes against myocardial ischemia/reperfusion injury (MI/RI) through inhibiting the NLRP3/Caspase-1/GSDMD signaling pathway.