Proinflammatory cytokines induce rapid, NO-independent apoptosis, expression of chemotactic mediators and interleukin-32 secretion in human pluripotent stem cell-derived beta cells

The promise of stem cell-derived islet replacement therapy

(2021) Douglas Melton   DIABETOLOGIA

Single-cell RNA sequencing of mouse islets exposed to proinflammatory cytokines

(2021) Jennifer S Stancill et al.   Life Science Alliance

Pro-inflammatory cytokines induce cell death, inflammatory responses, and endoplasmic reticulum stress in human iPSC-derived beta cells

(2020) Stéphane Demine et al.   Stem Cell Research & Therapy

Type 1 diabetes can present before the age of 6 months and is characterised by autoimmunity and rapid loss of beta cells

(2020) Matthew B. Johnson et al.   DIABETOLOGIA

The role of Interleukin‐32 in autoimmunity

(2020) Rafael Albuquerque et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

HLA Class II Antigen Processing and Presentation Pathway Components Demonstrated by Transcriptome and Protein Analyses of islet β-Cells from Donors with Type 1 Diabetes

(2019) Mark A. Russell et al.   DIABETES

Charting cellular identity during human in vitro β-cell differentiation

(2019) Adrian Veres et al.   NATURE

Early Detection of Peripheral Blood Cell Signature in Children Developing Beta-Cell Autoimmunity at a Young Age

(2019) Henna Kallionpää et al.   DIABETES

Children with type 1 diabetes of early age at onset – immune and metabolic phenotypes

(2019) Madalena Sales Luis et al.   JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM

The EndoC-βH1 cell line is a valid model of human beta cells and applicable for screenings to identify novel drug target candidates

(2018) Violeta Georgieva Tsonkova et al.   Molecular Metabolism

The Environmental Determinants of Diabetes in the Young (TEDDY) Study: 2018 Update

(2018) Marian Rewers et al.   Current Diabetes Reports

Adult-onset autoimmune diabetes: current knowledge and implications for management

(2017) Raffaella Buzzetti et al.   Nature Reviews Endocrinology

Sensitivity profile of the human EndoC-βH1 beta cell line to proinflammatory cytokines

(2016) Ewa Gurgul-Convey et al.   DIABETOLOGIA

Long-term glycemic control using polymer-encapsulated human stem cell–derived beta cells in immune-competent mice

(2016) Arturo J Vegas et al.   NATURE MEDICINE

Advances in islet encapsulation technologies

(2016) Tejal Desai et al.   NATURE REVIEWS DRUG DISCOVERY

Distinct differences in the responses of the human pancreatic β-cell line EndoC-βH1 and human islets to proinflammatory cytokines

(2015) Bryndon J. Oleson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Physiological characterization of the human EndoC-βH1 β-cell line

(2015) Ewa Gurgul-Convey et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cytokines induce endoplasmic reticulum stress in human, rat and mouse beta cells via different mechanisms

(2015) Flora Brozzi et al.   DIABETOLOGIA

Controlled induction of human pancreatic progenitors produces functional beta-like cells in vitro

(2015) H. A. Russ et al.   EMBO JOURNAL

Role of the AMP kinase in cytokine-induced human EndoC-βH1 cell death

(2015) Rikard G. Fred et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Generation of Functional Human Pancreatic β Cells In Vitro

(2014) Felicia W. Pagliuca et al.   CELL

Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells

(2014) Alireza Rezania et al.   NATURE BIOTECHNOLOGY

Age-dependent decline of β-cell function in type 1 diabetes after diagnosis: a multi-centre longitudinal study

(2013) A. Barker et al.   DIABETES OBESITY & METABOLISM

Characterization of polyhormonal insulin-producing cells derived in vitro from human embryonic stem cells

(2013) Jennifer E. Bruin et al.   Stem Cell Research

Cytokine-induced human islet cell death in vitro correlates with a persistently high phosphorylation of STAT-1, but not with NF-κB activation

(2012) Henrietta Hindlycke et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Human Pancreatic Islet Transcriptome: Expression of Candidate Genes for Type 1 Diabetes and the Impact of Pro-Inflammatory Cytokines

(2012) Décio L. Eizirik et al.   PLoS Genetics

A genetically engineered human pancreatic β cell line exhibiting glucose-inducible insulin secretion

(2011) Philippe Ravassard et al.   JOURNAL OF CLINICAL INVESTIGATION

Innate immunity triggers IL-32 expression by fibroblast-like synoviocytes in rheumatoid arthritis

(2010) Ghada Alsaleh et al.   ARTHRITIS RESEARCH & THERAPY

Proinflammatory Cytokines Activate the Intrinsic Apoptotic Pathway in  -Cells

(2009) L. G. Grunnet et al.   DIABETES

The role of inflammation in insulitis and β-cell loss in type 1 diabetes

(2009) Décio L. Eizirik et al.   Nature Reviews Endocrinology

Mediators and mechanisms of pancreatic beta-cell death in type 1 diabetes

(2008) Pierre Pirot et al.   Arquivos Brasileiros de Endocrinologia e Metabologia

Oxidative stress: the vulnerable β-cell

(2008) Sigurd Lenzen   BIOCHEMICAL SOCIETY TRANSACTIONS