Gut microbiota-derived butyrate regulates gut mucus barrier repair by activating the macrophage/WNT/ERK signaling pathway

Synbindin restrains proinflammatory macrophage activation against microbiota and mucosal inflammation during colitis

(2021) Luoyan Ai et al.   GUT

Niche-specific functional heterogeneity of intestinal resident macrophages

(2021) Maria Francesca Viola et al.   GUT

Prostaglandin E2 receptor PTGER4-expressing macrophages promote intestinal epithelial barrier regeneration upon inflammation

(2021) Yi Rang Na et al.   GUT

Effects of short chain fatty acids on metabolic and inflammatory processes in human health

(2021) Wendy Campos-Perez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Heme protects intestinal mucosal barrier in DSS‐induced colitis through regulating macrophage polarization in both HO‐1‐dependent and HO‐1‐independent way

(2020) Yanwei Wu et al.   FASEB JOURNAL

Microbiota-derived butyrate dynamically regulates intestinal homeostasis through regulation of actin-associated protein synaptopodin

(2020) Ruth X. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PTPN2 Regulates Interactions Between Macrophages and Intestinal Epithelial Cells to Promote Intestinal Barrier Function.

(2020) Marianne R. Spalinger et al.   GASTROENTEROLOGY

Human interleukin-4–treated regulatory macrophages promote epithelial wound healing and reduce colitis in a mouse model

(2020) Timothy S. Jayme et al.   Science Advances

Mucus barrier, mucins and gut microbiota: the expected slimy partners?

(2020) Paola Paone et al.   GUT

The intestinal barrier, an arbitrator turned provocateur in IBD

(2020) Saurabh Mehandru et al.   Nature Reviews Gastroenterology & Hepatology

The Short Chain Fatty Acid Butyrate Imprints an Antimicrobial Program in Macrophages

(2019) Julie Schulthess et al.   IMMUNITY

Structural weakening of the colonic mucus barrier is an early event in ulcerative colitis pathogenesis

(2019) Sjoerd van der Post et al.   GUT

YAP Aggravates Inflammatory Bowel Disease by Regulating M1/M2 Macrophage Polarization and Gut Microbial Homeostasis

(2019) Xin Zhou et al.   Cell Reports

Macrophages in intestinal inflammation and resolution: a potential therapeutic target in IBD

(2019) Yi Rang Na et al.   Nature Reviews Gastroenterology & Hepatology

Fusobacterium nucleatum Aggravates the Progression of Colitis by Regulating M1 Macrophage Polarization via AKT2 Pathway

(2019) Le Liu et al.   Frontiers in Immunology

Lipopolysaccharides modulate intestinal epithelial permeability and inflammation in a species-specific manner

(2019) Matthew Stephens et al.   Gut Microbes

VAMP8-mediated MUC2 mucin exocytosis from colonic goblet cells maintains innate intestinal homeostasis

(2019) Steve Cornick et al.   Nature Communications

The biology of mucus: Composition, synthesis and organization

(2018) Rama Bansil et al.   ADVANCED DRUG DELIVERY REVIEWS

Review article: short chain fatty acids as potential therapeutic agents in human gastrointestinal and inflammatory disorders

(2018) P. A. Gill et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Lactobacillus rhamnosusGG protects the intestinal epithelium from radiation injury through release of lipoteichoic acid, macrophage activation and the migration of mesenchymal stem cells

(2018) Terrence E Riehl et al.   GUT

A Cross-Talk Between Microbiota-Derived Short-Chain Fatty Acids and the Host Mucosal Immune System Regulates Intestinal Homeostasis and Inflammatory Bowel Disease

(2018) Pedro Gonçalves et al.   INFLAMMATORY BOWEL DISEASES

Sodium Butyrate Inhibits Inflammation and Maintains Epithelium Barrier Integrity in a TNBS-induced Inflammatory Bowel Disease Mice Model

(2018) Guangxin Chen et al.   EBioMedicine

Gut Microbiota Offers Universal Biomarkers across Ethnicity in Inflammatory Bowel Disease Diagnosis and Infliximab Response Prediction

(2018) Youlian Zhou et al.   mSystems

Temporal Regulation of the Bacterial Metabolite Deoxycholate during Colonic Repair Is Critical for Crypt Regeneration

(2018) Umang Jain et al.   Cell Host & Microbe

Impaired Intestinal Permeability Contributes to Ongoing Bowel Symptoms in Patients With Inflammatory Bowel Disease and Mucosal Healing

(2017) Jeff Chang et al.   GASTROENTEROLOGY

Macrophage-derived IL-10 mediates mucosal repair by epithelial WISP-1 signaling

(2017) Miguel Quiros et al.   JOURNAL OF CLINICAL INVESTIGATION

Determinants of Reduced Genetic Capacity for Butyrate Synthesis by the Gut Microbiome in Crohn’s Disease and Ulcerative Colitis

(2017) Emilio J Laserna-Mendieta et al.   Journal of Crohns & Colitis

c-Jun N-terminal kinase 2 promotes enterocyte survival and goblet cell differentiation in the inflamed intestine

(2017) A D Mandić et al.   Mucosal Immunology

Role of short-chain fatty acids in colonic inflammation, carcinogenesis, and mucosal protection and healing

(2017) Christina M. van der Beek et al.   NUTRITION REVIEWS

Alteration of the gut microbiota in Chinese population with chronic kidney disease

(2017) Shuanghong Jiang et al.   Scientific Reports

Colonic macrophage polarization in homeostasis, inflammation, and cancer

(2016) Raymond A. Isidro et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Macrophage-derived extracellular vesicle-packaged WNTs rescue intestinal stem cells and enhance survival after radiation injury

(2016) Subhrajit Saha et al.   Nature Communications

The microenvironment of injured murine gut elicits a local pro-restitutive microbiota

(2016) Ashfaqul Alam et al.   Nature Microbiology

Microbial metabolite butyrate facilitates M2 macrophage polarization and function

(2016) Jian Ji et al.   Scientific Reports

The activation of Wnt signaling by a STAT6-dependent macrophage phenotype promotes mucosal repair in murine IBD

(2015) J Cosín-Roger et al.   Mucosal Immunology

Wound repair: role of immune–epithelial interactions

(2015) G Leoni et al.   Mucosal Immunology

The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system

(2014) Thaher Pelaseyed et al.   IMMUNOLOGICAL REVIEWS

Interleukin-17 Induces an Atypical M2-Like Macrophage Subpopulation That Regulates Intestinal Inflammation

(2014) Kenichiro Nishikawa et al.   PLoS One

Shp2/MAPK signaling controls goblet/paneth cell fate decisions in the intestine

(2014) Julian Heuberger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bone marrow-derived alternatively activated macrophages reduce colitis without promoting fibrosis: participation of IL-10

(2013) Gabriella Leung et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

New targets for mucosal healing and therapy in inflammatory bowel diseases

(2013) M F Neurath   Mucosal Immunology

M2 Macrophages Activate WNT Signaling Pathway in Epithelial Cells: Relevance in Ulcerative Colitis

(2013) Jesús Cosín-Roger et al.   PLoS One

WNT3 Inhibits Cerebellar Granule Neuron Progenitor Proliferation and Medulloblastoma Formation via MAPK Activation

(2013) Sandrine L. Anne et al.   PLoS One

Mucosal healing in inflammatory bowel diseases: a systematic review

(2012) Markus F Neurath et al.   GUT

Goblet cells deliver luminal antigen to CD103+ dendritic cells in the small intestine

(2012) Jeremiah R. McDole et al.   NATURE

Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease

(2012) Luke Boulter et al.   NATURE MEDICINE

In Vitro-Derived Alternatively Activated Macrophages Reduce Colonic Inflammation in Mice

(2010) Meaghan M. Hunter et al.   GASTROENTEROLOGY

Macrophage Wnt7b is critical for kidney repair and regeneration

(2010) S.-L. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA