Protein Aggregation Is an Early Manifestation of Phospholamban p.(Arg14del)–Related Cardiomyopathy: Development of PLN-R14del–Related Cardiomyopathy

Functional analysis of a gene-edited mouse model to gain insights into the disease mechanisms of a titin missense variant

(2021) He Jiang et al.   BASIC RESEARCH IN CARDIOLOGY

The Unfolded Protein Response as a Compensatory Mechanism and Potential Therapeutic Target in PLN R14del Cardiomyopathy

(2021) Dries A.M. Feyen et al.   CIRCULATION

Impairment of the ER/mitochondria compartment in human cardiomyocytes with PLN p.Arg14del mutation

(2021) Friederike Cuello et al.   EMBO Molecular Medicine

Toward standardization of echocardiography for the evaluation of left ventricular function in adult rodents: a position paper of the ESC Working Group on Myocardial Function

(2020) Serena Zacchigna et al.   CARDIOVASCULAR RESEARCH

Sex‐related differences in contemporary biomarkers for heart failure: a review

(2020) Navin Suthahar et al.   EUROPEAN JOURNAL OF HEART FAILURE

The Molecular Chaperone CCT/TRiC: An Essential Component of Proteostasis and a Potential Modulator of Protein Aggregation

(2020) Julie Grantham   Frontiers in Genetics

The phospholamban p.(Arg14del) pathogenic variant leads to cardiomyopathy with heart failure and is unreponsive to standard heart failure therapy

(2020) Tim R. Eijgenraam et al.   Scientific Reports

The effects of liraglutide and dapagliflozin on cardiac function and structure in a multi-hit mouse model of Heart Failure with Preserved Ejection Fraction

(2020) Coenraad Withaar et al.   CARDIOVASCULAR RESEARCH

Ketone Ester Treatment Improves Cardiac Function and Reduces Pathologic Remodeling in Preclinical Models of Heart Failure

(2020) Salva R. Yurista et al.   Circulation-Heart Failure

The Gene Ontology resource: enriching a GOld mine

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A novel method optimizing the normalization of cardiac parameters in small animal models: the importance of dimensional indexing

(2019) Quint A. J. Hagdorn et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Heart failure in cardiomyopathies: a position paper from the Heart Failure Association of the European Society of Cardiology

(2019) Petar M. Seferović et al.   EUROPEAN JOURNAL OF HEART FAILURE

Sodium–glucose co‐transporter 2 inhibition with empagliflozin improves cardiac function in non‐diabetic rats with left ventricular dysfunction after myocardial infarction

(2019) Salva R. Yurista et al.   EUROPEAN JOURNAL OF HEART FAILURE

Current understanding of fibrosis in genetic cardiomyopathies

(2019) Tim R. Eijgenraam et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Genetics of dilated cardiomyopathy: practical implications for heart failure management

(2019) Andrew N. Rosenbaum et al.   Nature Reviews Cardiology

Pharmacological myeloperoxidase (MPO) inhibition in an obese/hypertensive mouse model attenuates obesity and liver damage, but not cardiac remodeling

(2019) Arnold Piek et al.   Scientific Reports

OPLAH ablation leads to accumulation of 5-oxoproline, oxidative stress, fibrosis and elevated fillings pressures: a murine model for heart failure with a preserved ejection fraction

(2018) Atze van der Pol et al.   CARDIOVASCULAR RESEARCH

Evaluation of a commercial multi-dimensional echocardiography technique for ventricular volumetry in small animals

(2018) Jana Grune et al.   Cardiovascular Ultrasound

The Failing Heart Stimulates Tumor Growth by Circulating Factors

(2018) Wouter C. Meijers et al.   CIRCULATION

Systems analysis of dilated cardiomyopathy in the next generation sequencing era

(2018) Magdalena Harakalova et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Myocardial fibrosis as an early feature in phospholamban p.Arg14del mutation carriers: phenotypic insights from cardiovascular magnetic resonance imaging

(2018) Wouter P te Rijdt et al.   European Heart Journal-Cardiovascular Imaging

Plasma levels of heart failure biomarkers are primarily a reflection of extracardiac production

(2018) Weijie Du et al.   Theranostics

The PRIDE database and related tools and resources in 2019: improving support for quantification data

(2018) Yasset Perez-Riverol et al.   NUCLEIC ACIDS RESEARCH

Phospholamban p.Arg14del cardiomyopathy is characterized by phospholamban aggregates, aggresomes, and autophagic degradation

(2016) Wouter P te Rijdt et al.   HISTOPATHOLOGY

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Outcome in Phospholamban R14del Carriers: Results of a Large Multicentre Cohort Study

(2014) I. A. W. van Rijsingen et al.   Circulation-Cardiovascular Genetics

Prognostic implications of global LV dysfunction: a systematic review and meta-analysis of global longitudinal strain and ejection fraction

(2014) Kashif Kalam et al.   HEART

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

(2013) Y. Liao et al.   BIOINFORMATICS

Predicting the molecular complexity of sequencing libraries

(2013) Timothy Daley et al.   NATURE METHODS

RSeQC: quality control of RNA-seq experiments

(2012) Liguo Wang et al.   BIOINFORMATICS

SortMeRNA: fast and accurate filtering of ribosomal RNAs in metatranscriptomic data

(2012) Evguenia Kopylova et al.   BIOINFORMATICS

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Genetic and Pharmacological Inhibition of Galectin-3 Prevents Cardiac Remodeling by Interfering With Myocardial Fibrogenesis

(2012) Lili Yu et al.   Circulation-Heart Failure

Phospholamban R14del mutation in patients diagnosed with dilated cardiomyopathy or arrhythmogenic right ventricular cardiomyopathy: evidence supporting the concept of arrhythmogenic cardiomyopathy

(2012) Paul A. van der Zwaag et al.   EUROPEAN JOURNAL OF HEART FAILURE

The human phospholamban Arg14-deletion mutant localizes to plasma membrane and interacts with the Na/K-ATPase

(2011) Kobra Haghighi et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research

(2010) Carol Kilkenny et al.   PLOS BIOLOGY

Genetic deletion of arginine 14 in phospholamban causes dilated cardiomyopathy with attenuated electrocardiographic R amplitudes

(2009) Maximilian G. Posch et al.   HEART RHYTHM

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols