Article
Cardiac & Cardiovascular Systems
Tejas Deshmukh, Peter Emerson, Paul Geenty, Shehane Mahendran, Luke Stefani, Megan Hogg, Paula Brown, Shyam Panicker, James Chong, Mikhail Altman, David Gottlieb, Liza Thomas
Summary: Two-dimensional multiplanar speckle tracking strain is useful in evaluating cardiac dysfunction post allogenic bone marrow transplantation, especially in patients pretreated with anthracyclines. Reduction in global circumferential strain may be influenced by preconditioning and is not solely explained by anthracycline exposure.
Article
Radiology, Nuclear Medicine & Medical Imaging
Ernesto Di Cesare, Scipione Carerj, Anna Palmisano, Maria Ludovica Carerj, Federica Catapano, Davide Vignale, Annamaria Di Cesare, Gianluca Milanese, Nicola Sverzellati, Marco Francone, Antonio Esposito
Summary: Heart failure is prevalent in developed countries, with common symptoms including shortness of breath, swelling, and fatigue. Multimodality imaging is crucial for determining etiology, prognosis, and tailored treatments. Echocardiography and cardiac magnetic resonance imaging play important roles in diagnosis and follow-up of HF patients.
Review
Cardiac & Cardiovascular Systems
Mehmet Gunata, Hakan Parlakpinar
Summary: Heart failure (HF) is a critical health and economic burden that has been increasing in prevalence worldwide. Experimental HF models have provided valuable insights into the pathophysiology of HF and have been successful in studying its etiology and treatment. However, each animal model has its limitations, and none of them can fully capture all aspects of HF.
HEART FAILURE REVIEWS
(2023)
Review
Cardiac & Cardiovascular Systems
Matthew Kodsi, David Makarious, Gary C. H. Gan, Preeti Choudhary, Liza Thomas
Summary: Recent advancements in heart failure therapies, combined with non-invasive cardiac imaging techniques, have led to improved clinical and structural outcomes. Reverse remodelling, as a biomarker for treatment success, has been correlated with patients' clinical response. The introduction of new therapeutic agents and the evaluation of cardiac reverse remodelling using non-invasive methods have expanded the possibilities for successful treatment.
Article
Chemistry, Analytical
Shih-Po Su, Syue-Liang Lin, Yang-Hsiang Chan, Yi-Jang Lee, Yun-Chen Lee, Pin-Xuan Zeng, Yi-Xuan Li, Muh-Hwa Yang, Huihua Kenny Chiang
Summary: Near-infrared-II (NIR-II) fluorescence imaging offers high spatial resolution and deep tissue penetration for visualization of blood vessels and tumors in deep tissue. In this study, a stereo NIR-II fluorescence imaging system was developed, along with fluorescent semiconducting polymer dots with ultra-bright NIR-II fluorescence for long-term imaging. The system successfully obtained high-resolution 3D blood vessel images.
Review
Oncology
Marjolein Priester, Sergio Curto, Gerard C. van Rhoon, Timo L. M. ten Hagen
Summary: Mild hyperthermia shows promise as an adjuvant for solid tumor treatment, but standardization of experimental design and methods is crucial for enhancing reproducibility and facilitating comparison of results.
Review
Cardiac & Cardiovascular Systems
Edgar Argulian, Jagat Narula
Summary: Cardiovascular imaging plays a crucial role in assessing patients with heart failure, providing detailed functional, hemodynamic, and tissue characterization. However, there is a lack of adoption of a new framework in clinical trials for diagnosing and phenotyping heart failure that includes comprehensive imaging assessment. This review offers an overview of available imaging strategies for patients with heart failure.
JACC-HEART FAILURE
(2021)
Review
Pharmacology & Pharmacy
Yan Wang, Miao Wang, Chrishan S. Samuel, Robert E. Widdop
Summary: Cardiac fibrosis, characterized by increased ECM deposition, is a hallmark of most cardiovascular diseases and inhibition of fibrosis could improve outcomes in heart failure patients. However, pharmacological treatment targeting ECM buildup remains limited. Animal models are important for understanding fibrosis pathogenesis and identifying new therapeutic targets.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Acoustics
Theoharis Drakos, Marinos Giannakou, Georgios Menikou, Christakis Damianou
Summary: A positioning device compatible with MRI for preclinical studies in small animals has been developed and evaluated for functionality using magnetic resonance thermometry, showing good thermal energy deposition and positional accuracy. Due to its size, it is currently primarily used for preclinical studies in small animals.
JOURNAL OF ULTRASOUND IN MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Amil. M. M. Shah, Brian Claggett, Narayana Prasad, Guichu Li, Mayra Volquez, Karola Jering, Maja Cikes, Attila Kovacs, Wilfried Mullens, Jose C. Nicolau, Lars Kober, Peter Van der Meer, Pardeep. S. S. Jhund, Ghionul Ibram, Martin Lefkowitz, Yinong Zhou, Scott. D. D. Solomon, Marc A. Pfeffer
Summary: This study compared the effects of sacubitril/valsartan and ramipril on left ventricular function and adverse remodeling after acute myocardial infarction (AMI). The results showed that patients randomized to sacubitril/valsartan had better improvements in filling pressure, left ventricular volume changes, and other aspects compared to those randomized to ramipril.
Article
Clinical Neurology
J. B. M. Warntjes, P. Lundberg, A. Tisell
Summary: In this study, a 3D MR imaging quantification sequence was used to synthesize a T1-weighted image stack for brain volume measurement. The repeatability and reproducibility of using the conventional and synthetic input data were evaluated.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Otto A. Smiseth, Daniel A. Morris, Nuno Cardim, Maja Cikes, Victoria Delgado, Erwan Donal, Frank A. Flachskampf, Maurizio Galderisi, Bernhard L. Gerber, Alessia Gimelli, Allan L. Klein, Juhani Knuuti, Patrizio Lancellotti, Julia Mascherbauer, Davor Milicic, Petar Seferovic, Scott Solomon, Thor Edvardsen, Bogdan A. Popescu
Summary: Heart failure with preserved ejection fraction (HFpEF) has a prognosis similar to heart failure with reduced EF (HFrEF), but treatment options are limited. HFpEF may involve a wide range of pathological processes, which can be differentiated using multimodality imaging.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Sungwoo Choi, Sangun Nah, Young Soon Cho, Inki Moon, Jae Wook Lee, Choung Ah Lee, Ji Eun Moon, Sangsoo Han
Summary: This study aimed to confirm the effect of augmented reality (AR) glasses on echocardiographic interpretation in patients with heart failure (HF). The results showed that the use of AR glasses improved the consistency of left ventricular ejection fraction (LVEF) measurements, especially for less experienced physicians.
Review
Radiology, Nuclear Medicine & Medical Imaging
Hermine Mohr, Alessia Foscarini, Katja Steiger, Simone Ballke, Christoph Rischpler, Franz Schilling, Natalia S. Pellegata
Summary: PPGLs are rare tumors that require timely diagnosis and treatment to prevent potential serious complications. Advances in biochemical diagnosis and genetic understanding have been made, and new imaging technologies are useful for patient monitoring and treatment stratification. Effective animal models are essential for translating laboratory research to the clinic.
Article
Cardiac & Cardiovascular Systems
Ilya Karagodin, Megan Yamat, Alasdair Dow, Lydia Rivera, Amita Singh, Karima Addetia, Jeanne M. DeCara, Cristiane Carvalho Singulane, Michael Henry, Eric Kruse, Amit R. Patel, Victor Mor-Avi, Roberto M. Lang
Summary: The addition of transparency in transthoracic echocardiography significantly improves image quality and diagnostic confidence when compared to standard 3D rendering. Experts perceived incremental value of transillumination with transparency in terms of ability to identify anatomy or pathology, depth perception, degree of anatomic detail, and border delineation.
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2022)
Article
Critical Care Medicine
Ye Fan, An -Mei Zhang, Xian-Li Wu, Zan-Sheng Huang, Konstantina Kontogianni, Kai Sun, Wan -Lei Fu, Na Wu, Wolfgang M. Kuebler, Felix J. F. Herth
Summary: The study evaluated the safety and value of combining transbronchial mediastinal cryobiopsy with standard EBUS-TBNA for diagnosing mediastinal diseases. Results showed that this combined approach significantly increased the overall diagnostic yield for mediastinal lesions, particularly in benign disorders.
LANCET RESPIRATORY MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Charles Fauvel, Guillaume Bonnet, Wilfried Mullens, Clara Ines Saldarriaga Giraldo, Anja Zupan Meznar, Anders Barasa, Mariya Tokmakova, Anastasia Shchendrygina, Francisco Moscoso Costa, Massimo Mapelli, Filip Zemrak, Laurens F. Tops, Nina Jakus, Arian Sultan, Fadel Bahouth, Chahr-Eddine Hadjseyd, Muriel Salvat, Matteo Anselmino, Daniel Messroghli, Vanessa Weberndorfer, Ilya Giverts, Thomas Bochaton, Emmanuelle Berthelot, Damien Legallois, Florence Beauvais, Fabrice Bauer, Nicolas Lamblin, Thibaud Damy, Nicolas Girerd, Laurent Sebbag, Theo Pezel, Alain Cohen-Solal, Giuseppe Rosano, Francois Roubille, Nathan Mewton
Summary: This study aimed to understand the perception of practicing cardiologists and heart failure (HF) specialists regarding the recommendation of initiating four major therapeutic classes simultaneously in patients with heart failure and reduced ejection fraction. The survey findings showed that most cardiologists still preferred the historical approach of sequential initiation, although accelerated introduction and titration were also considered important treatment goals.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Biochemistry & Molecular Biology
Nicolas Campolo, Mauricio Mastrogiovanni, Michele Mariotti, Federico M. Issoglio, Dario Estrin, Per Hagglund, Tilman Grune, Michael J. Davies, Silvina Bartesaghi, Rafael Radi
Summary: Glutamine synthetase (GS) is an important enzyme that plays a crucial role in nitrogen metabolism. This study investigated the oxidative inactivation of human GS by peroxynitrite (ONOO-) in vitro. The results showed that ONOO- exposure led to a dose-dependent loss of GS activity and various oxidative modifications of the enzyme. Multiple tyrosine nitration sites and dityrosine cross-links were identified, but nitration of specific tyrosine residues alone was not responsible for enzyme inactivation. In addition, ONOO- induced GS aggregation and activity loss, with thiol oxidation being a key modification to elicit aggregation.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2023)
Review
Physiology
Wolfgang M. Kuebler, Nishaka William, Martin Post, Jason P. Acker, Mark J. Mcvey
Summary: Respiratory transfusion reactions, especially transfusion-related acute lung injury (TRALI), have significant morbidity and mortality. Current methods of diagnosing and treating TRALI are limited. EVs play a role in mediating TRALI by acting as triggers for the first and/ or second hit. Further research is needed to explore EVs as therapeutic targets and biomarkers for TRALI diagnosis.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Tilman Grune, Vanessa Schnell, Tobias Jung
Summary: The impact of high glucose on cellular redox state, induction of antioxidative systems, and enhanced protein oxidation has been extensively discussed. It is known that elevated glucose levels disrupt cellular proteostasis and influence the proteasomal system. However, it is still unclear whether this is a direct reaction of the proteasomal system to high glucose or a secondary reaction to inflammatory stimuli. In this study, a dermal fibroblast cell line was exposed to high glucose to investigate if a response of the proteasomal system occurs. The study found changes in enzyme activity, expression levels, and nuclear redistribution of proteasomal components, suggesting that high glucose alone can provoke a regulatory response on the ubiquitin-proteasomal system without additional inflammatory stimuli.
Article
Pharmacology & Pharmacy
Moritz Hertel, Saskia Preissner, Bjorn O. Gohike, Wolfgang M. Kuebler, Gema Hernandez, Mehmet Akyuz, Robert Preissner
Summary: This study analyzed the difference in ventilation procedures and hospitalization risk between patients with pulmonary hypertension (PH) who used dipyrone and those who did not. The results showed that patients who used dipyrone had significantly lower risks of ventilation and hospitalization. These findings are important for patients with PH and may encourage further research.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Peripheral Vascular Disease
Rui Zhang, Ji Zhang, Yun-Long Zhang, Su-Gang Gong, Qin-Hua Zhao, Xiao-Juan Wang, Jia-Yu Zhao, Rong Jiang, Hong-Ling Qiu, Hui-Ting Li, Jing He, Shao-Fei Liu, Wolfgang M. Kuebler, Lan Wang
Summary: This study provides a reference atlas of neutrophils in patients with IPAH and identifies MMP9 as a potential biomarker for prognosis.
Article
Nutrition & Dietetics
Thorsten Henning, Philipp Wagner, Egbert Gedat, Bastian Kochlik, Paula Kusch, Kay Sowoidnich, Marko Vastag, Jeannine Gleim, Marcel Braune, Martin Maiwald, Bernd Sumpf, Tilman Grune, Daniela Weber
Summary: The study compares non-invasive methods, such as skin measurements and an app-based short dietary record (ASDR), with conventional methods to assess dietary carotenoids. The results show that app-based intake data and skin measurements have good correlations with plasma carotenoids, making them convenient alternatives for assessing fruit and vegetable consumption. The findings suggest that ASDR records can be a suitable tool for dietary assessment in nutritional intervention studies.
Article
Nutrition & Dietetics
Thorsten Henning, Bastian Kochlik, Ignacio Ara, Marcela Gonzalez-Gross, Edoardo Fiorillo, Michele Marongiu, Francesco Cucca, Fernando Rodriguez-Artalejo, Jose Antonio Carnicero Carreno, Leocadio Rodriguez-Manas, Tilman Grune, Daniela Weber
Summary: The study examines the influence of nutritional factors on frailty syndrome and identifies cross-sectional associations between diet-related blood biomarker patterns and frailty status. The results demonstrate that older adults with higher concentrations of total carotenoids, beta-carotene, and beta-cryptoxanthin are relatively robust, while those with higher lutein + zeaxanthin concentrations are more frail. These findings provide guidance for the development of future biomarker-based frailty indices.
Article
Nutrition & Dietetics
Robertina Giacconi, Francesco Piacenza, Valentina Aversano, Michele Zampieri, Alexander Buerkle, Maria Moreno Villanueva, Martijn E. T. Dolle, Eugene Jansen, Tilman Grune, Efstathios S. Gonos, Claudio Franceschi, Miriam Capri, Birgit Weinberger, Ewa Sikora, Olivier Toussaint, Florence Debacq-Chainiaux, Wolfgang Stuetz, Pieternella Eline Slagboom, Juergen Bernhardt, Maria Luisa Fernandez-Sanchez, Mauro Provinciali, Marco Malavolta
Summary: Plasma selenium levels are influenced by age, sex, nutrition, and inflammation. Inadequate selenium intake can accelerate aging and increase the risk of age-related diseases.
Article
Medicine, General & Internal
Magdalena L. Laux, Christian Braun, Filip Schroeter, Daniela Weber, Aiman Moldasheva, Tilman Grune, Roya Ostovar, Martin Hartrumpf, Johannes Maximilian Albes
Summary: Frailty is an important risk factor in cardiothoracic surgery and various frailty scores have been developed. This study analyzed the frailty and outcomes of 246 patients undergoing cardiac surgery, finding that frail patients had longer hospital stays, higher complication rates, and increased 1-year mortality. Additionally, postoperative changes in laboratory markers were observed in frail patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Dov Lichtenberg, Ilya Pinchuk, Eleni Yonassi, Daniela Weber, Tilman Grune
Summary: The maintenance of steady-state redox status is crucial for physiological well-being. Changes in this status can lead to either beneficial signaling or oxidative damage. Quantitative evaluation of oxidative stress (OS) is challenging due to the lack of universal biomarkers, hindering selective antioxidant treatment for individuals experiencing OS. Without the ability to determine and quantify OS, therapeutic interventions based on the identify-and-treat approach cannot be assessed and are unlikely to form the basis for selective preventive measures against oxidative damage.
Article
Nutrition & Dietetics
Nadine Rohwer, Racha El Hage, Christopher Smyl, Soeren Ocvirk, Tobias Goris, Tilman Grune, Alexander Swidsinski, Karsten-H. Weylandt
Summary: In this study, the effect of a 4-week ketogenic diet (KD) on the colonic microbiome of mice was examined. The results showed significant changes in the composition and quantity of gut bacteria, indicating possible anti-inflammatory effects of the KD. The findings suggest that the differential abundance of specific genera in the microbiota may be responsible for the health effects of the KD.
Article
Cardiac & Cardiovascular Systems
Niklas Hegemann, Willem Bintig, Paul-Lennard Perret, Judith Rees, Alessandra Viperino, Britta Eickholt, Wolfgang M. M. Kuebler, Michael Hoepfner, Bianca Nitzsche, Jana Grune
Summary: Preclinical cardiovascular research heavily relies on non-invasive echocardiography in mice and rats to assess cardiac function and morphology. This study tested the feasibility of using an in-ovo system of incubated chicken eggs interfaced with small animal echocardiography as an alternative tool for cardiovascular research. Detailed standard operating procedures and reference values were provided, demonstrating the sensitivity of in-ovo echocardiography.
BASIC RESEARCH IN CARDIOLOGY
(2023)
Letter
Biochemistry & Molecular Biology
Dwi Cahyo Budi Setiawan, Szandor Simmons, Laura Michalick, Wolfgang M. Kuebler
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2023)