Inflammatory Glycoprotein 130 Signaling Links Changes in Microtubules and Junctophilin-2 to Altered Mitochondrial Metabolism and Right Ventricular Contractility

Transcriptomic Analysis of Right Ventricular Remodeling in Two Rat Models of Pulmonary Hypertension

(2021) John F. Park et al.   Circulation-Heart Failure

Cellular sources of IL-6 and associations with clinical phenotypes and outcomes in PAH

(2020) Catherine E. Simpson et al.   EUROPEAN RESPIRATORY JOURNAL

IL-6 in pulmonary hypertension: why novel is not always best

(2020) Mark Toshner et al.   EUROPEAN RESPIRATORY JOURNAL

Excess Protein O-GlcNAcylation Links Metabolic Derangements to Right Ventricular Dysfunction in Pulmonary Arterial Hypertension

(2020) Sasha Z. Prisco et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cells of the adult human heart

(2020) Monika Litviňuková et al.   NATURE

Association of mitochondria with microtubules inhibits mitochondrial fission by precluding assembly of the fission protein Dnm1

(2019) Kritika Mehta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pleiotropy and Specificity: Insights from the Interleukin 6 Family of Cytokines

(2019) Masaaki Murakami et al.   IMMUNITY

Cardiac microtubules in health and heart disease

(2019) Matthew A Caporizzo et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Ectopic upregulation of membrane-bound IL6R drives vascular remodeling in pulmonary arterial hypertension

(2018) Yuichi Tamura et al.   JOURNAL OF CLINICAL INVESTIGATION

Interleukin-6 is independently associated with right ventricular function in pulmonary arterial hypertension

(2018) Kurt W. Prins et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Transcriptomic Signature of Right Ventricular Failure in Experimental Pulmonary Arterial Hypertension: Deep Sequencing Demonstrates Mitochondrial, Fibrotic, Inflammatory and Angiogenic Abnormalities

(2018) Francois Potus et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Haemodynamic definitions and updated clinical classification of pulmonary hypertension

(2018) Gérald Simonneau et al.   EUROPEAN RESPIRATORY JOURNAL

Pathophysiology of the right ventricle and of the pulmonary circulation in pulmonary hypertension: an update

(2018) Anton Vonk Noordegraaf et al.   EUROPEAN RESPIRATORY JOURNAL

Repurposing Medications for Treatment of Pulmonary Arterial Hypertension: What's Old Is New Again

(2018) Kurt W. Prins et al.   Journal of the American Heart Association

Ischemia-induced Drp1 and Fis1-mediated mitochondrial fission and right ventricular dysfunction in pulmonary hypertension

(2017) Lian Tian et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Colchicine Depolymerizes Microtubules, Increases Junctophilin‐2, and Improves Right Ventricular Function in Experimental Pulmonary Arterial Hypertension

(2017) Kurt W. Prins et al.   Journal of the American Heart Association

Fatty Acid Metabolic Defects and Right Ventricular Lipotoxicity in Human Pulmonary Arterial HypertensionClinical Perspective

(2016) Evan L. Brittain et al.   CIRCULATION

Junctophilin-2 gene therapy rescues heart failure by normalizing RyR2-mediated Ca2+ release

(2016) Julia O. Reynolds et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Detyrosinated microtubules buckle and bear load in contracting cardiomyocytes

(2016) P. Robison et al.   SCIENCE

The harmonizome: a collection of processed datasets gathered to serve and mine knowledge about genes and proteins

(2016) Andrew D. Rouillard et al.   Database-The Journal of Biological Databases and Curation

Deletion of interleukin-6 alleviated interstitial fibrosis in streptozotocin-induced diabetic cardiomyopathy of mice through affecting TGFβ1 and miR-29 pathways

(2016) Yang Zhang et al.   Scientific Reports

Pulmonary Pulse Wave Transit Time is Associated with Right Ventricular–Pulmonary Artery Coupling in Pulmonary Arterial Hypertension

(2016) Kurt W. Prins et al.   Pulmonary Circulation

Automatic quantitative analysis of t-tubule organization in cardiac myocytes using ImageJ

(2015) Côme Pasqualin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

STAT3 Association with Microtubules and Its Activation Are Independent of HDAC6 Activity

(2015) Bing Yan et al.   DNA AND CELL BIOLOGY

Imbalanced OPA1 processing and mitochondrial fragmentation cause heart failure in mice

(2015) T. Wai et al.   SCIENCE

Emerging roles of junctophilin-2 in the heart and implications for cardiac diseases

(2014) David L. Beavers et al.   CARDIOVASCULAR RESEARCH

Microtubule-Mediated Defects in Junctophilin-2 Trafficking Contribute to Myocyte Transverse-Tubule Remodeling and Ca 2+ Handling Dysfunction in Heart Failure

(2014) Caimei Zhang et al.   CIRCULATION

Therapeutic targeting of the oncostatin M receptor-β prevents inflammatory heart failure

(2013) Jochen Pöling et al.   BASIC RESEARCH IN CARDIOLOGY

Moonlighting microtubule-associated proteins: Regulatory functions by day and pathological functions at night

(2013) J. Oláh et al.   Cytoskeleton

Plasma interleukin-6 adds prognostic information in pulmonary arterial hypertension

(2013) G. A. Heresi et al.   EUROPEAN RESPIRATORY JOURNAL

Cardiac glutaminolysis: a maladaptive cancer metabolism pathway in the right ventricle in pulmonary hypertension

(2013) Lin Piao et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Discovery of a Novel Orally Active Small-Molecule gp130 Inhibitor for the Treatment of Ovarian Cancer

(2013) S. Xu et al.   MOLECULAR CANCER THERAPEUTICS

Kissing and nanotunneling mediate intermitochondrial communication in the heart

(2013) X. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial Trafficking in Neurons

(2013) T. L. Schwarz   Cold Spring Harbor Perspectives in Biology

Primer-BLAST: A tool to design target-specific primers for polymerase chain reaction

(2012) Jian Ye et al.   BMC BIOINFORMATICS

Plasticity and cross-talk of Interleukin 6-type cytokines

(2012) Christoph Garbers et al.   CYTOKINE & GROWTH FACTOR REVIEWS

FOXO1-mediated upregulation of pyruvate dehydrogenase kinase-4 (PDK4) decreases glucose oxidation and impairs right ventricular function in pulmonary hypertension: therapeutic benefits of dichloroacetate

(2012) Lin Piao et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Sildenafil Prevents and Reverses Transverse-Tubule Remodeling and Ca 2+ Handling Dysfunction in Right Ventricle Failure Induced by Pulmonary Artery Hypertension

(2011) Yu-Ping Xie et al.   HYPERTENSION

Parthenolide inhibits STAT3 signaling and attenuates angiotensin II-induced left ventricular hypertrophy via modulation of fibroblast activity

(2011) Réka Skoumal et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Validation of high-resolution echocardiography and magnetic resonance imaging vs. high-fidelity catheterization in experimental pulmonary hypertension

(2010) Dalia Urboniene et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Elevated Levels of Inflammatory Cytokines Predict Survival in Idiopathic and Familial Pulmonary Arterial Hypertension

(2010) Elaine Soon et al.   CIRCULATION

Opposing Actions of Extracellular Signal-regulated Kinase (ERK) and Signal Transducer and Activator of Transcription 3 (STAT3) in Regulating Microtubule Stabilization during Cardiac Hypertrophy

(2010) Dominic C. H. Ng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Animal models of pulmonary arterial hypertension: the hope for etiological discovery and pharmacological cure

(2009) Kurt R. Stenmark et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Integrated, Nontargeted Ultrahigh Performance Liquid Chromatography/Electrospray Ionization Tandem Mass Spectrometry Platform for the Identification and Relative Quantification of the Small-Molecule Complement of Biological Systems

(2009) Anne M. Evans et al.   ANALYTICAL CHEMISTRY

Dystrophin is a microtubule-associated protein

(2009) Kurt W. Prins et al.   JOURNAL OF CELL BIOLOGY

Mitochondrial function and morphology are impaired inparkin-mutant fibroblasts

(2008) Heather Mortiboys et al.   ANNALS OF NEUROLOGY