Emerging roles of junctophilin-2 in the heart and implications for cardiac diseases

Microtubule-Mediated Defects in Junctophilin-2 Trafficking Contribute to Myocyte Transverse-Tubule Remodeling and Ca 2+ Handling Dysfunction in Heart Failure

(2014) Caimei Zhang et al.   CIRCULATION

EHD1 mediates vesicle trafficking required for normal muscle growth and transverse tubule development

(2014) Avery D. Posey et al.   DEVELOPMENTAL BIOLOGY

Ultrastructural uncoupling between T-tubules and sarcoplasmic reticulum in human heart failure

(2013) H.-B. Zhang et al.   CARDIOVASCULAR RESEARCH

Critical roles of junctophilin-2 in T-tubule and excitation–contraction coupling maturation during postnatal development

(2013) Biyi Chen et al.   CARDIOVASCULAR RESEARCH

Junctophilin-2 is necessary for T-tubule maturation during mouse heart development

(2013) Julia O. Reynolds et al.   CARDIOVASCULAR RESEARCH

Calcium signalling microdomains and the t-tubular system in atrial mycoytes: potential roles in cardiac disease and arrhythmias

(2013) Andrew W. Trafford et al.   CARDIOVASCULAR RESEARCH

Mutation E169K in Junctophilin-2 Causes Atrial Fibrillation Due to Impaired RyR2 Stabilization

(2013) David L. Beavers et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Subclinical Abnormalities in Sarcoplasmic Reticulum Ca2+ Release Promote Eccentric Myocardial Remodeling and Pump Failure Death in Response to Pressure Overload

(2013) Simon Sedej et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Morphogenesis of T-tubules in heart cells: the role of junctophilin-2

(2013) Jing Han et al.   Science China-Life Sciences

Altered Splicing of the BIN1 Muscle-Specific Exon in Humans and Dogs with Highly Progressive Centronuclear Myopathy

(2013) Johann Böhm et al.   PLoS Genetics

Posttranslational modifications of cardiac ryanodine receptors: Ca2+ signaling and EC-coupling

(2012) Ernst Niggli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Nanoscale Organization of Junctophilin-2 and Ryanodine Receptors within Peripheral Couplings of Rat Ventricular Cardiomyocytes

(2012) Isuru D. Jayasinghe et al.   BIOPHYSICAL JOURNAL

Activation of proteolytic enzymes and depression of the sarcolemmal Na+/K+-ATPase in ischemia–reperfused heart may be mediated through oxidative stress

(2012) Raja B. Singh et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Ultrastructural remodelling of Ca2+ signalling apparatus in failing heart cells

(2012) Hao-Di Wu et al.   CARDIOVASCULAR RESEARCH

Enhanced Sarcoplasmic Reticulum Ca 2+ Leak and Increased Na + -Ca 2+ Exchanger Function Underlie Delayed Afterdepolarizations in Patients With Chronic Atrial Fibrillation

(2012) Niels Voigt et al.   CIRCULATION

Mir-24 Regulates Junctophilin-2 Expression in Cardiomyocytes

(2012) Ming Xu et al.   CIRCULATION RESEARCH

Stimulated Emission Depletion Live-Cell Super-Resolution Imaging Shows Proliferative Remodeling of T-Tubule Membrane Structures After Myocardial Infarction

(2012) Eva Wagner et al.   CIRCULATION RESEARCH

Beyond the Cardiac Myofilament: Hypertrophic Cardiomyopathy- Associated Mutations in Genes that Encode Calcium-Handling Proteins

(2012) A. P. Landstrom et al.   CURRENT MOLECULAR MEDICINE

β-Adrenergic receptor antagonists ameliorate myocyte T-tubule remodeling following myocardial infarction

(2012) Biyi Chen et al.   FASEB JOURNAL

Ca2+-dependent proteolysis of junctophilin-1 and junctophilin-2 in skeletal and cardiac muscle

(2012) R. M. Murphy et al.   JOURNAL OF PHYSIOLOGY-LONDON

Disrupted Junctional Membrane Complexes and Hyperactive Ryanodine Receptors After Acute Junctophilin Knockdown in Mice

(2011) Ralph J. van Oort et al.   CIRCULATION

Inhibition of CaMKII Phosphorylation of RyR2 Prevents Induction of Atrial Fibrillation in FKBP12.6 Knockout Mice

(2011) Na Li et al.   CIRCULATION RESEARCH

Junctophilin-2 Expression Silencing Causes Cardiocyte Hypertrophy and Abnormal Intracellular Calcium-Handling

(2011) Andrew P. Landstrom et al.   Circulation-Heart Failure

The Achilles’ Heel of Cardiovascular Genetic Testing: Distinguishing Pathogenic Mutations From Background Genetic Noise

(2011) A P Landstrom et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

BIN1 is reduced and Cav1.2 trafficking is impaired in human failing cardiomyocytes

(2011) Ting-Ting Hong et al.   HEART RHYTHM

Sildenafil Prevents and Reverses Transverse-Tubule Remodeling and Ca 2+ Handling Dysfunction in Right Ventricle Failure Induced by Pulmonary Artery Hypertension

(2011) Yu-Ping Xie et al.   HYPERTENSION

Junctophilin 1 and 2 Proteins Interact with the L-type Ca2+Channel Dihydropyridine Receptors (DHPRs) in Skeletal Muscle

(2011) Lucia Golini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recent advances in the molecular pathophysiology of atrial fibrillation

(2011) Reza Wakili et al.   JOURNAL OF CLINICAL INVESTIGATION

Changes in the Organization of Excitation-Contraction Coupling Structures in Failing Human Heart

(2011) David J. Crossman et al.   PLoS One

T-tubule biogenesis and triad formation in skeletal muscle and implication in human diseases

(2011) Lama Al-Qusairi et al.   Skeletal Muscle

S165F mutation of junctophilin 2 affects Ca2+signalling in skeletal muscle

(2010) Jin Seok Woo et al.   BIOCHEMICAL JOURNAL

The ryanodine receptor channel as a molecular motif in atrial fibrillation: pathophysiological and therapeutic implications

(2010) D. Dobrev et al.   CARDIOVASCULAR RESEARCH

T-Tubule Remodeling During Transition From Hypertrophy to Heart Failure

(2010) Sheng Wei et al.   CIRCULATION RESEARCH

CaMKII-Dependent Diastolic SR Ca 2+ Leak and Elevated Diastolic Ca 2+ Levels in Right Atrial Myocardium of Patients With Atrial Fibrillation

(2010) Stefan Neef et al.   CIRCULATION RESEARCH

Accelerated Development of Pressure Overload–Induced Cardiac Hypertrophy and Dysfunction in an RyR2-R176Q Knockin Mouse Model

(2010) Ralph J. van Oort et al.   HYPERTENSION

The effect of exercise training on transverse tubules in normal, remodeled, and reverse remodeled hearts

(2010) Ole J. Kemi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Store overload-induced Ca2+release as a triggering mechanism for CPVT and MH episodes caused by mutations inRYRandCASQgenes

(2010) David H. MacLennan et al.   JOURNAL OF PHYSIOLOGY-LONDON

BIN1 Localizes the L-Type Calcium Channel to Cardiac T-Tubules

(2010) Ting-Ting Hong et al.   PLOS BIOLOGY

The Ca V 3.2 T-Type Ca 2+ Channel Is Required for Pressure Overload–Induced Cardiac Hypertrophy in Mice

(2009) Chien-Sung Chiang et al.   CIRCULATION RESEARCH

Three-dimensional electron microscopy reveals new details of membrane systems for Ca2+ signaling in the heart

(2009) T. Hayashi et al.   JOURNAL OF CELL SCIENCE

Excitation–contraction coupling changes during postnatal cardiac development

(2009) Andrew P. Ziman et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Glutamate at position 227 of junctophilin-2 is involved in binding to TRPC3

(2009) Jin Seok Woo et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Molecular evolution of the junctophilin gene family

(2009) Alejandro Garbino et al.   PHYSIOLOGICAL GENOMICS

miR-23a functions downstream of NFATc3 to regulate cardiac hypertrophy

(2009) Z. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of T-tubules and other changes to surface topography in ventricular myocytes from failing human and rat heart

(2009) A. R. Lyon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caveolae, ion channels and cardiac arrhythmias

(2009) Ravi C. Balijepalli et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

TRPC3-interacting triadic proteins in skeletal muscle

(2008) Jin Seok Woo et al.   BIOCHEMICAL JOURNAL

Ca 2+ Influx Through T- and L-Type Ca 2+ Channels Have Different Effects on Myocyte Contractility and Induce Unique Cardiac Phenotypes

(2008) Naser Jaleel et al.   CIRCULATION RESEARCH

Intracellular calcium leak due to FKBP12.6 deficiency in mice facilitates the inducibility of atrial fibrillation

(2008) Subeena Sood et al.   HEART RHYTHM