Start a fire, kill the bug: The role of platelets in inflammation and infection

The contribution of platelet glycoprotein receptors to inflammatory bleeding prevention is stimulus and organ dependent

(2018) Julie Rayes et al.   HAEMATOLOGICA

Platelets and vascular integrity

(2018) Carsten Deppermann   PLATELETS

The contribution of platelet glycoprotein receptors to inflammatory bleeding prevention is stimulus and organ dependent

(2018) Julie Rayes et al.   HAEMATOLOGICA

Platelets as autonomous drones for hemostatic and immune surveillance

(2017) Jackson LiangYao Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Host DNases prevent vascular occlusion by neutrophil extracellular traps

(2017) Miguel Jiménez-Alcázar et al.   SCIENCE

The podoplanin-CLEC-2 axis inhibits inflammation in sepsis

(2017) Julie Rayes et al.   Nature Communications

Thrombocytopenia is associated with a dysregulated host response in critically ill sepsis patients

(2016) T. A. M. Claushuis et al.   BLOOD

Dual-Track Clearance of Circulating Bacteria Balances Rapid Restoration of Blood Sterility with Induction of Adaptive Immunity

(2016) Steven P. Broadley et al.   Cell Host & Microbe

CRIg Functions as a Macrophage Pattern Recognition Receptor to Directly Bind and Capture Blood-Borne Gram-Positive Bacteria

(2016) Zhutian Zeng et al.   Cell Host & Microbe

Cross Talk Pathways Between Coagulation and Inflammation

(2016) Jonathan H. Foley et al.   CIRCULATION RESEARCH

Dysregulation of angiopoietin-1 plays a mechanistic role in the pathogenesis of cerebral malaria

(2016) Sarah J. Higgins et al.   Science Translational Medicine

Platelets and infection

(2016) Carsten Deppermann et al.   SEMINARS IN IMMUNOLOGY

Platelets: New Bricks in the Building of Neutrophil Extracellular Traps

(2016) Agostina Carestia et al.   Frontiers in Immunology

Platelet GPVI repairs its own damage

(2015) J. Rayes et al.   BLOOD

Podoplanin and CLEC-2 drive cerebrovascular patterning and integrity during development

(2015) K. L. Lowe et al.   BLOOD

Single platelets seal neutrophil-induced vascular breaches via GPVI during immune-complex-mediated inflammation in mice

(2015) A. Gros et al.   BLOOD

Platelet secretion: From haemostasis to wound healing and beyond

(2015) Ewelina M. Golebiewska et al.   BLOOD REVIEWS

Synergistic Action of Staphylococcus aureus α-Toxin on Platelets and Myeloid Lineage Cells Contributes to Lethal Sepsis

(2015) Michael E. Powers et al.   Cell Host & Microbe

Inflammation drives thrombosis after Salmonella infection via CLEC-2 on platelets

(2015) Jessica R. Hitchcock et al.   JOURNAL OF CLINICAL INVESTIGATION

Blocking neutrophil diapedesis prevents hemorrhage during thrombocytopenia

(2015) Carina Hillgruber et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The expanding field of platelet–bacterial interconnections

(2015) Steven W. Kerrigan   PLATELETS

CLEC-2 expression is maintained on activated platelets and on platelet microparticles

(2014) E. Gitz et al.   BLOOD

Thrombocytopenia impairs host defense in gram-negative pneumonia-derived sepsis in mice

(2014) S. F. de Stoppelaar et al.   BLOOD

Gray platelet syndrome: proinflammatory megakaryocytes and  -granule loss cause myelofibrosis and confer metastasis resistance in mice

(2014) J. A. Guerrero et al.   BLOOD

Platelet Immunoreceptor Tyrosine-Based Activation Motif (ITAM) Signaling and Vascular Integrity

(2014) Yacine Boulaftali et al.   CIRCULATION RESEARCH

Neutrophils scan for activated platelets to initiate inflammation

(2014) Vinatha Sreeramkumar et al.   SCIENCE

Synchronized integrin engagement and chemokine activation is crucial in neutrophil extracellular trap-mediated sterile inflammation

(2013) J. Rossaint et al.   BLOOD

Congenital platelet disorders and understanding of platelet function

(2013) Alan T. Nurden et al.   BRITISH JOURNAL OF HAEMATOLOGY

Platelet-Derived Nucleotides Promote Tumor-Cell Transendothelial Migration and Metastasis via P2Y2 Receptor

(2013) Dagmar Schumacher et al.   CANCER CELL

Neutrophil and platelet complexes and their relevance to neutrophil recruitment and activation

(2013) Clive Page et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Gray platelet syndrome and defective thrombo-inflammation in Nbeal2-deficient mice

(2013) Carsten Deppermann et al.   JOURNAL OF CLINICAL INVESTIGATION

Munc13-4 is critical for thrombosis through regulating release of ADP from platelets

(2013) J. S. Savage et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Munc13-4-mediated secretion is essential for infarct progression but not intracranial hemostasis in acute stroke

(2013) D. Stegner et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The organizing principle of the platelet glycoprotein Ib-IX-V complex

(2013) R. Li et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Immune surveillance by the liver

(2013) Craig N Jenne et al.   NATURE IMMUNOLOGY

Nucleation of platelets with blood-borne pathogens on Kupffer cells precedes other innate immunity and contributes to bacterial clearance

(2013) Connie H Y Wong et al.   NATURE IMMUNOLOGY

Severe Sepsis and Septic Shock

(2013) Derek C. Angus et al.   NEW ENGLAND JOURNAL OF MEDICINE

Crosstalk between platelets and the complement system in immune protection and disease

(2013) Harald F. Langer et al.   THROMBOSIS AND HAEMOSTASIS

Platelet count or bleeding as the outcome in ITP trials?

(2012) Donald M. Arnold   AMERICAN JOURNAL OF HEMATOLOGY

Intravascular Neutrophil Extracellular Traps Capture Bacteria from the Bloodstream during Sepsis

(2012) Braedon McDonald et al.   Cell Host & Microbe

Platelets Contribute to the Pathogenesis of Experimental Autoimmune Encephalomyelitis

(2012) Harald F. Langer et al.   CIRCULATION RESEARCH

Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury

(2012) Axelle Caudrillier et al.   JOURNAL OF CLINICAL INVESTIGATION

Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo

(2012) Marie-Luise von Brühl et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Infection-induced NETosis is a dynamic process involving neutrophil multitasking in vivo

(2012) Bryan G Yipp et al.   NATURE MEDICINE

Hospitalizations, costs, and outcomes of severe sepsis in the United States 2003 to 2007

(2011) Tara Lagu et al.   CRITICAL CARE MEDICINE

Alternative Pathway Activation of Complement by Shiga Toxin Promotes Exuberant C3a Formation That Triggers Microvascular Thrombosis

(2011) M. Morigi et al.   JOURNAL OF IMMUNOLOGY

Ischaemic stroke: a thrombo-inflammatory disease?

(2011) Bernhard Nieswandt et al.   JOURNAL OF PHYSIOLOGY-LONDON

A platelet-mediated system for shuttling blood-borne bacteria to CD8α+ dendritic cells depends on glycoprotein GPIb and complement C3

(2011) Admar Verschoor et al.   NATURE IMMUNOLOGY

Novel Anti-bacterial Activities of β-defensin 1 in Human Platelets: Suppression of Pathogen Growth and Signaling of Neutrophil Extracellular Trap Formation

(2011) Bjoern F. Kraemer et al.   PLoS Pathogens

Differentially regulated GPVI ectodomain shedding by multiple platelet-expressed proteinases

(2010) M. Bender et al.   BLOOD

Platelets regulate lymphatic vascular development through CLEC-2-SLP-76 signaling

(2010) C. C. Bertozzi et al.   BLOOD

Inflammation and coagulation

(2010) Marcel Levi et al.   CRITICAL CARE MEDICINE

Circulating platelet-neutrophil complexes are important for subsequent neutrophil activation and migration

(2010) Kristin N. Kornerup et al.   JOURNAL OF APPLIED PHYSIOLOGY

Complement Component C3 Binds to Activated Normal Platelets without Preceding Proteolytic Activation and Promotes Binding to Complement Receptor 1

(2010) Osama A. Hamad et al.   JOURNAL OF IMMUNOLOGY

Invasive Streptococcus pneumoniae trigger platelet activation via Toll-like receptor 2

(2010) C. KEANE et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

GPVI and CLEC-2 in hemostasis and vascular integrity

(2010) S. P. WATSON et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Complement activation on platelets: Implications for vascular inflammation and thrombosis

(2010) Ellinor I. Peerschke et al.   MOLECULAR IMMUNOLOGY

An intravascular immune response to Borrelia burgdorferi involves Kupffer cells and iNKT cells

(2010) Woo-Yong Lee et al.   NATURE IMMUNOLOGY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Platelets Amplify Inflammation in Arthritis via Collagen-Dependent Microparticle Production

(2010) E. Boilard et al.   SCIENCE

CLEC-2 is an essential platelet-activating receptor in hemostasis and thrombosis

(2009) F. May et al.   BLOOD

Platelet α-granules: Basic biology and clinical correlates

(2009) Price Blair et al.   BLOOD REVIEWS

Elucidating the role ofStaphylococcus epidermidisserine-aspartate repeat protein G in platelet activation

(2009) M. P. BRENNAN et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Platelets Kill Intraerythrocytic Malarial Parasites and Mediate Survival to Infection

(2009) B. J. McMorran et al.   SCIENCE

CD40 Ligand Promotes Mac-1 Expression, Leukocyte Recruitment, and Neointima Formation after Vascular Injury

(2008) Guohong Li et al.   AMERICAN JOURNAL OF PATHOLOGY

Platelet Chemokines in Vascular Disease

(2008) Christian A. Gleissner et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Platelets: Inflammatory Firebugs of Vascular Walls

(2008) Andreas E. May et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Inflammation induces hemorrhage in thrombocytopenia

(2008) T. Goerge et al.   BLOOD

Toll-like receptor 4 ligand can differentially modulate the release of cytokines by human platelets

(2008) Fabrice Cognasse et al.   BRITISH JOURNAL OF HAEMATOLOGY

Platelet Granule Secretion Continuously Prevents Intratumor Hemorrhage

(2008) B. Ho-Tin-Noe et al.   CANCER RESEARCH

Primary and secondary capture of platelets onto inflamed femoral artery endothelium is dependent on P-selectin and PSGL-1

(2008) Oscar Ö. Braun et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Complement activation triggered by chondroitin sulfate released by thrombin receptor-activated platelets

(2008) O. A. HAMAD et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS