α5-nAChR associated with Ly6E modulates cell migration via TGF-β1/Smad signaling in non-small cell lung cancer

Preclinical optimization of Ly6E-targeted ADCs for increased durability and efficacy of anti-tumor response

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Biochemistry of nicotine metabolism and its relevance to lung cancer

(2021) Sharon E. Murphy   JOURNAL OF BIOLOGICAL CHEMISTRY

Human Three-Finger Protein Lypd6 Is a Negative Modulator of the Cholinergic System in the Brain

(2021) Dmitrii Kulbatskii et al.   Frontiers in Cell and Developmental Biology

CHRNA5 rs16969968 polymorphism is associated with lung cancer risk: A meta‐analysis

(2020) Wei Zhou et al.   Clinical Respiratory Journal

α5‐nAChR contributes to epithelial‐mesenchymal transition and metastasis by regulating Jab1/Csn5 signalling in lung cancer

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Inhaled nicotine and lung cancer: Potential role of the nicotinic acetylcholine receptor

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Human secreted protein SLURP-1 abolishes nicotine-induced proliferation, PTEN down-regulation and α7-nAChR expression up-regulation in lung cancer cells

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Snake three-finger α-neurotoxins and nicotinic acetylcholine receptors: molecules, mechanisms and medicine

(2020) Selvanayagam Nirthanan   BIOCHEMICAL PHARMACOLOGY

A Phase I study of DLYE5953A, an anti-LY6E antibody covalently linked to monomethyl auristatin E, in patients with refractory solid tumors

(2020) Sara M Tolaney et al.   CLINICAL CANCER RESEARCH

Three‐finger proteins from snakes and humans acting on nicotinic receptors: Old and new

(2020) Victor I. Tsetlin et al.   JOURNAL OF NEUROCHEMISTRY

LY6E impairs coronavirus fusion and confers immune control of viral disease

(2020) Stephanie Pfaender et al.   Nature Microbiology

Dissecting the genetic overlap of smoking behaviors, lung cancer, and chronic obstructive pulmonary disease: A focus on nicotinic receptors and nicotine metabolizing enzyme

(2020) Michael J. Bray et al.   GENETIC EPIDEMIOLOGY

Low-Dose Nicotine Activates EGFR Signaling via α5-nAChR and Promotes Lung Adenocarcinoma Progression

(2020) Mong-Lien Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Association between Metabolites and the Risk of Lung Cancer: A Systematic Literature Review and Meta-Analysis of Observational Studies

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Polysaccharide isolated from persimmon leaves (Diospyros kaki Thunb.) suppresses TGF-β1-induced epithelial-to-mesenchymal transition in A549 cells

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Inflection of Akt/mTOR/STAT-3 cascade in TNF-α induced protein 8 mediated human lung carcinogenesis

(2020) Devivasha Bordoloi et al.   LIFE SCIENCES

Exosomes Derived from Human Urine-Derived Stem Cells Inhibit Intervertebral Disc Degeneration by Ameliorating Endoplasmic Reticulum Stress

(2020) HongFei Xiang et al.   Oxidative Medicine and Cellular Longevity

Lung Adenocarcinoma Mouse Models Based on Orthotopic Transplantation of Syngeneic Tumor-Initiating Cells Expressing EpCAM, SCA-1, and Ly6d

(2020) Takashi Semba et al.   Cancers

The Risks and Benefits of Immune Checkpoint Blockade in Anti-AChR Antibody-Seropositive Non-Small Cell Lung Cancer Patients

(2019) Koichi Saruwatari et al.   Cancers

Prevention and Early Detection for NSCLC: Advances in Thoracic Oncology 2018

(2019) Haval Balata et al.   Journal of Thoracic Oncology

From Synthetic Fragments of Endogenous Three-Finger Proteins to Potential Drugs

(2019) Elena V. Kryukova et al.   Frontiers in Pharmacology

Emerging Role of Lymphocyte Antigen-6 Family of Genes in Cancer and Immune Cells

(2019) Geeta Upadhyay   Frontiers in Immunology

Emerging Role of LY6E in Virus–Host Interactions

(2019) Jingyou Yu et al.   Viruses-Basel

CHRNA3 rs1051730 and CHRNA5 rs16969968 polymorphisms are associated with heavy smoking, lung cancer, and chronic obstructive pulmonary disease in a mexican population

(2018) Rebeca Pérez-Morales et al.   ANNALS OF HUMAN GENETICS

Epithelial-to-mesenchymal transition in the context of epidermal growth factor receptor inhibition in non-small-cell lung cancer

(2018) Giuseppe Bronte et al.   BIOLOGICAL REVIEWS

Perception of Lung Cancer Risk: Impact of Smoking Status and Nicotine Dependence

(2018) Laurent Greillier et al.   Current Oncology Reports

Effect of nicotine dependence on quality of life and sleep quality in patients with lung cancer who continue to smoke after diagnosis

(2018) Fen Gu et al.   Journal of Thoracic Disease

Regulation of Sox2 and stemness by nicotine and electronic-cigarettes in non-small cell lung cancer

(2018) Courtney M Schaal et al.   Molecular Cancer

Acetylcholine signaling system in progression of lung cancers

(2018) Jamie R. Friedman et al.   PHARMACOLOGY & THERAPEUTICS

Reciprocal activation of α5-nAChR and STAT3 in nicotine-induced human lung cancer cell proliferation

(2017) Yao Zhang et al.   Journal of Genetics and Genomics

Alpha5 Nicotinic Acetylcholine Receptor Contributes to Nicotine-Induced Lung Cancer Development and Progression

(2017) Hai-Ji Sun et al.   Frontiers in Pharmacology

Ly6E/K Signaling to TGF  Promotes Breast Cancer Progression, Immune Escape, and Drug Resistance

(2016) M. AlHossiny et al.   CANCER RESEARCH

Nicotine-Mediated Regulation of Nicotinic Acetylcholine Receptors in Non-Small Cell Lung Adenocarcinoma by E2F1 and STAT1 Transcription Factors

(2016) Courtney Schaal et al.   PLoS One

Distinct lymphocyte antigens 6 (Ly6) family members Ly6D, Ly6E, Ly6K and Ly6H drive tumorigenesis and clinical outcome

(2016) Linlin Luo et al.   Oncotarget

LY6E: a conductor of malignant tumor growth through modulation of the PTEN/PI3K/Akt/HIF-1 axis

(2016) Chan Joo Yeom et al.   Oncotarget

Genetic Risk Can Be Decreased: Quitting Smoking Decreases and Delays Lung Cancer for Smokers With High and Low CHRNA5 Risk Genotypes — A Meta-Analysis

(2016) Li-Shiun Chen et al.   EBioMedicine

The Oncogenic Functions of Nicotinic Acetylcholine Receptors

(2016) Yue Zhao   Journal of Oncology

Nicotine Inhibits Cisplatin-Induced Apoptosis via Regulating α5-nAChR/AKT Signaling in Human Gastric Cancer Cells

(2016) Yanfei Jia et al.   PLoS One

α5-nAChR modulates nicotine-induced cell migration and invasion in A549 lung cancer cells

(2015) Haiji Sun et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Role of Lynx1 and related Ly6 proteins as modulators of cholinergic signaling in normal and neoplastic bronchial epithelium

(2015) Xiao Wen Fu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Recent progress in revealing the biological and medical significance of the non-neuronal cholinergic system

(2015) Sergei A. Grando et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

AtCNGC2 is involved in jasmonic acid-induced calcium mobilization

(2015) Min Lu et al.   JOURNAL OF EXPERIMENTAL BOTANY

Three-finger snake neurotoxins and Ly6 proteins targeting nicotinic acetylcholine receptors: pharmacological tools and endogenous modulators

(2015) Victor I. Tsetlin   TRENDS IN PHARMACOLOGICAL SCIENCES

The Role of nAChR and Calcium Signaling in Pancreatic Cancer Initiation and Progression

(2015) Courtney Schaal et al.   Cancers

Contribution of Variants in CHRNA5/A3/B4 Gene Cluster on Chromosome 15 to Tobacco Smoking: From Genetic Association to Mechanism

(2014) Li Wen et al.   MOLECULAR NEUROBIOLOGY

Alpha5 nicotinic acetylcholine receptor mediates nicotine-induced HIF-1α and VEGF expression in non-small cell lung cancer

(2014) Xiaoli Ma et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

CHRNA5 as negative regulator of nicotine signaling in normal and cancer bronchial cells: effects on motility, migration and p63 expression

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