An update on microcrystalline cellulose in direct compression: Functionality, critical material attributes, and co-processed excipients
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Title
An update on microcrystalline cellulose in direct compression: Functionality, critical material attributes, and co-processed excipients
Authors
Keywords
Microcrystalline cellulose, Direct compression, Tablet, Critical material attributes, Co-processed excipient
Journal
CARBOHYDRATE POLYMERS
Volume 278, Issue -, Pages 118968
Publisher
Elsevier BV
Online
2021-12-02
DOI
10.1016/j.carbpol.2021.118968
References
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Note: Only part of the references are listed.- Application of Aquasolv Lignin in ibuprofen-loaded pharmaceutical formulations obtained via direct compression and wet granulation
- (2021) Joana Gil-Chávez et al. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
- Nanomechanical mapping and strain rate sensitivity of microcrystalline cellulose
- (2021) Kevin M. Schmalbach et al. JOURNAL OF MATERIALS RESEARCH
- Tablet disintegration performance: Effect of compression pressure and storage conditions on surface liquid absorption and swelling kinetics
- (2021) Daniel Markl et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- The influence of particle size on the application of compression and compaction models for tableting
- (2021) Isabell Wünsch et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Performance Evaluation of a Novel Biosourced Co-Processed Excipient in Direct Compression and Drug Release
- (2021) Rihab Benabbas et al. Polymers
- Investigating microcrystalline cellulose crystallinity using Raman spectroscopy
- (2021) Ana Luiza P. Queiroz et al. CELLULOSE
- Effect of whey protein isolate/chitosan/microcrystalline cellulose/PET multilayer bottles on the shelf life of rosebud beverages
- (2021) Zi-Chun Wang et al. FOOD CHEMISTRY
- Exploitation of Design-of-Experiment Approach for Design and Optimization of Fast-Disintegrating Tablets for Sublingual Delivery of Sildenafil Citrate with Enhanced Bioavailability Using Fluid-Bed Granulation Technique
- (2021) Amer S. AlAli et al. Pharmaceutics
- Effect of particle size on powder compaction and tablet strength using limestone
- (2020) Ramon Cabiscol et al. ADVANCED POWDER TECHNOLOGY
- Using fractal dimension and shape factors to characterize the microcrystalline cellulose (MCC) particle morphology and powder flowability
- (2020) Huijuan Xiu et al. POWDER TECHNOLOGY
- Investigation of powder flowability at low stresses: Influence of particle size and size distribution
- (2020) Alexandros Georgios Stavrou et al. POWDER TECHNOLOGY
- Monitoring lubricant addition in pharmaceutical tablet manufacturing through passive vibration measurements in a V-blender
- (2020) Austin Cameron et al. POWDER TECHNOLOGY
- Contact Behavior of Microcrystalline Cellulose Pellets Depending on their Water Content
- (2020) Philipp Grohn et al. CHEMICAL ENGINEERING & TECHNOLOGY
- Isolation and characterization of microcrystalline cellulose from date seeds (Phoenix dactylifera L.)
- (2020) Nedal Y. Abu-Thabit et al. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
- Greener production of microcrystalline cellulose (MCC) from Saccharum spontaneum (Kans grass): Statistical optimization
- (2020) Julie Baruah et al. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
- Cushioning pellets based on microcrystalline cellulose – Crospovidone blends for MUPS tableting
- (2020) Ramy N. Elsergany et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Morphological, Physiochemical and Thermal Properties of Microcrystalline Cellulose (MCC) Extracted from Bamboo Fiber
- (2020) Masrat Rasheed et al. MOLECULES
- A Precise Prediction Method for the Properties of API-Containing Tablets Based on Data from Placebo Tablets
- (2020) Yoshihiro Hayashi et al. Pharmaceutics
- Preparation and Optimization of Multi-Functional Directly Compressible Excipient: An Integrated Approach Of Principal Component Analysis And Design Of Experiments
- (2020) Dhaval Mori et al. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
- Evaluation of an external lubrication system implemented in a compaction simulator
- (2020) Cedrine de Backere et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Characterization and modeling of the viscoelasticity of pharmaceutical tablets
- (2020) Léo Desbois et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Effect of particle size and deformation behaviour on water ingress into tablets
- (2020) Anne Linnet Skelbæk-Pedersen et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Tabletability Flip – Role of Bonding Area and Bonding Strength Interplay
- (2020) Shubhajit Paul et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Pharmaceutical Application of Tablet Film Coating
- (2020) Ki-Soo Seo et al. Pharmaceutics
- Micro and nanocrystalline cellulose derivatives of lignocellulosic biomass: A review on synthesis, applications and advancements
- (2020) Dibyajyoti Haldar et al. CARBOHYDRATE POLYMERS
- Multivariate analysis for optimization and validation of the industrial tablet-manufacturing process
- (2020) Marcel Prikeržnik et al. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
- Development and pharmaceutical performance of a novel co-processed excipient of alginic acid and microcrystalline cellulose
- (2020) R. Benabbas et al. POWDER TECHNOLOGY
- Control strategy and methods for continuous direct compression processes
- (2020) Yasuhiro Suzuki et al. Asian Journal of Pharmaceutical Sciences
- Biodegradable nanoparticles from prosopisylated cellulose as a platform for enhanced oral bioavailability of poorly water-soluble drugs
- (2020) Franklin Chimaobi Kenechukwu et al. CARBOHYDRATE POLYMERS
- A Mathematical Approach to Consider Solid Compressibility in the Compression of Pharmaceutical Powders
- (2019) Isabell Wünsch et al. Pharmaceutics
- Critical Excipient Attributes Relevant to Solid Dosage Formulation Manufacturing
- (2019) Naseem Ahmad Charoo Journal of Pharmaceutical Innovation
- Effects of Moisture on the Mechanical Properties of Microcrystalline Cellulose and the Mobility of the Water Molecules as Studied by the Hybrid Molecular Mechanics-Molecular Dynamics Simulation Method
- (2019) Iwan H. Sahputra et al. JOURNAL OF POLYMER SCIENCE PART B-POLYMER PHYSICS
- Utility of Microcrystalline Cellulose for Improving Drug Content Uniformity in Tablet Manufacturing Using Direct Powder Compression
- (2019) Shohei Nakamura et al. AAPS PHARMSCITECH
- A simple process of isolation microcrystalline cellulose using ultrasonic irradiation
- (2019) Endarto Yudo Wardhono et al. JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY
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- (2019) Gasper J. Fernandes et al. Journal of Pharmaceutical Innovation
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- (2019) Rawan Bafail et al. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
- Microcrystalline cellulose from Posidonia oceanica brown algae: Extraction and characterization
- (2019) Ahmed Fouzi Tarchoun et al. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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- (2019) Yuanyuan Zhang et al. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
- Quality by design in pharmaceutical manufacturing: A systematic review of current status, challenges and future perspectives
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- Investigation of the effects of particle size on fragmentation during tableting
- (2019) Anne Linnet Skelbæk-Pedersen et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Co-Processed Excipients for Dispersible Tablets–Part 1: Manufacturability
- (2018) Ben J. Bowles et al. AAPS PHARMSCITECH
- Co-Processed Excipients for Dispersible Tablets—Part 2: Patient Acceptability
- (2018) Karolina Dziemidowicz et al. AAPS PHARMSCITECH
- Resolving the rapid water absorption of porous functionalised calcium carbonate powder compacts by terahertz pulsed imaging
- (2018) Daniel Markl et al. CHEMICAL ENGINEERING RESEARCH & DESIGN
- Systematic evaluation of common lubricants for optimal use in tablet formulation
- (2018) Shubhajit Paul et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- A mechanistic study on tablet ejection force and its sensitivity to lubrication for pharmaceutical powders
- (2018) Bekuechukwu Uzondu et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Surface engineered excipients: II. Simultaneous milling and dry coating for preparation of fine-grade microcrystalline cellulose with enhanced properties
- (2018) Liang Chen et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Surface engineered excipients: I. improved functional properties of fine grade microcrystalline cellulose
- (2018) Liang Chen et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- The effect of mechanical dry coating with magnesium stearate on flowability and compactibility of plastically deforming microcrystalline cellulose powders
- (2018) Jaana Koskela et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Self-microemulsifying tablets prepared by direct compression for improved resveratrol delivery
- (2018) Katarina Bolko Seljak et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Three-dimensional discrete element modelling of three point bending tests: The effect of surface energy on the tensile strength
- (2018) Simone Loreti et al. POWDER TECHNOLOGY
- Evaluation and Comparison of Three Types of Spray Dried Coprocessed Excipient Avicel® for Direct Compression
- (2018) Pavlína Vodáčková et al. Biomed Research International
- Preparation of Sustained Release Tablet with Minimized Usage of Glyceryl Behenate Using Post-Heating Method
- (2018) Changmin Kang et al. AAPS PHARMSCITECH
- Quality by design (QbD) approaches in current pharmaceutical set-up
- (2018) Vijay Mishra et al. Expert Opinion on Drug Delivery
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- (2018) Nirupaplava Metta et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
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- (2018) Xianzhen Yin et al. POWDER TECHNOLOGY
- Reproducibility of the Measurement of Bulk/Tapped Density of Pharmaceutical Powders Between Pharmaceutical Laboratories
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- (2018) Isaac Nofrerias et al. POWDER TECHNOLOGY
- Machine learning plastic deformation of crystals
- (2018) Henri Salmenjoki et al. Nature Communications
- Surface engineered excipients: III. Facilitating direct compaction tableting of binary blends containing fine cohesive poorly-compactable APIs
- (2018) Liang Chen et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Evaluation of novel microcrystalline cellulose from Ensete glaucum (Roxb.) Cheesman biomass as sustainable drug delivery biomaterial
- (2018) Lalduhsanga Pachuau et al. CARBOHYDRATE POLYMERS
- Isolation and characterization of microcrystalline cellulose from roselle fibers
- (2017) Lau Kia Kian et al. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
- Classification of microcrystalline celluloses via structures of individual particles measured by synchrotron radiation X-ray micro-computed tomography
- (2017) Longwei Fang et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- A compressibility based model for predicting the tensile strength of directly compressed pharmaceutical powder mixtures
- (2017) Gavin K. Reynolds et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Relationships between response surfaces for tablet characteristics of placebo and API-containing tablets manufactured by direct compression method
- (2017) Yoshihiro Hayashi et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Matrix tablets based on amino acid-derived polyesteramide containing release modifiers
- (2017) Ana Dora Bonillo Martínez et al. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
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- (2017) Ravindra D. Kale et al. JOURNAL OF POLYMERS AND THE ENVIRONMENT
- Dependence of Friability on Tablet Mechanical Properties and a Predictive Approach for Binary Mixtures
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- An investigation into the effects of excipient particle size, blending techniques and processing parameters on the homogeneity and content uniformity of a blend containing low-dose model drug
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- Influence of moisture content on the flow properties of basundi mix
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- Application of quality by design in the current drug development
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- Comparison of Conventional and Lignin-Rich Microcrystalline Cellulose
- (2016) Kari Mikael Vanhatalo et al. BioResources
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- (2016) Fatma Kallel et al. INDUSTRIAL CROPS AND PRODUCTS
- Microcrystalline cellulose: Isolation, characterization and bio-composites application—A review
- (2016) Djalal Trache et al. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
- A study of a novel coprocessed dry binder composed of α-lactose monohydrate, microcrystalline cellulose and corn starch
- (2016) Jitka Mužíková et al. PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
- Denatured Whey Protein Powder as a New Matrix Excipient: Design and Evaluation of Mucoadhesive Tablets for Sustained Drug Release Applications
- (2016) Hassana Hsein et al. PHARMACEUTICAL RESEARCH
- A critical Examination of the Phenomenon of Bonding Area - Bonding Strength Interplay in Powder Tableting
- (2016) Frederick Osei-Yeboah et al. PHARMACEUTICAL RESEARCH
- Quantifying effects of moisture content on flow properties of microcrystalline cellulose using a ring shear tester
- (2016) Changquan Calvin Sun POWDER TECHNOLOGY
- Optimization of Time Controlled 6-mercaptopurine Delivery for Site- Specific Targeting to Colon Diseases
- (2016) Rahul U. Hude et al. Current Drug Delivery
- Effects of particle size on the triboelectrification phenomenon in pharmaceutical excipients: Experiments and multi-scale modeling
- (2016) Raj Mukherjee et al. Asian Journal of Pharmaceutical Sciences
- The Effect of Microcrystalline Cellulose Crystallinity on the Hydrophilic Property of Tablets and the Hydrolysis of Acetylsalicylic Acid as Active Pharmaceutical Ingredient Inside Tablets
- (2015) Kimie Awa et al. AAPS PHARMSCITECH
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- (2015) Xiao Li et al. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
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- (2015) Xingchu Gong et al. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
- Understanding the impact of microcrystalline cellulose physicochemical properties on tabletability
- (2015) Gregory Thoorens et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- The Disintegration Process in Microcrystalline Cellulose Based Tablets, Part 1: Influence of Temperature, Porosity and Superdisintegrants
- (2015) Samy Yassin et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Excipient Variability and Its Impact on Dosage Form Functionality
- (2015) Vivek S. Dave et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- An Effect of Cellulose Crystallinity on the Moisture Absorbability of a Pharmaceutical Tablet Studied by Near-Infrared Spectroscopy
- (2015) Kimie Awa et al. APPLIED SPECTROSCOPY
- Microcrystalline cellulose, a direct compression binder in a quality by design environment—A review
- (2014) Gregory Thoorens et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Monitoring of Recrystallisation of Microcrystalline Cellulose inside Pharmaceutical Tablets during Storage Using near Infrared Diffuse Reflectance Spectroscopy
- (2014) Kimie Awa et al. JOURNAL OF NEAR INFRARED SPECTROSCOPY
- Deformation and Mechanical Characteristics of Compacted Binary Mixtures of Plastic (Microcrystalline Cellulose), Elastic (Sodium Starch Glycolate), and Brittle (Lactose Monohydrate) Pharmaceutical Excipients
- (2013) Zahraa A. Mousa Al-Ibraheemi et al. PARTICULATE SCIENCE AND TECHNOLOGY
- Synthesis and characterization of microcrystalline cellulose produced from bacterial cellulose
- (2011) Rafael Leite de Oliveira et al. JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
- Reproducibility of flow properties of microcrystalline cellulose — Avicel PH102
- (2011) Limin Shi et al. POWDER TECHNOLOGY
- Mechanism of moisture induced variations in true density and compaction properties of microcrystalline cellulose
- (2007) Changquan Calvin Sun INTERNATIONAL JOURNAL OF PHARMACEUTICS
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