Mutant IDH1 promotes phagocytic function of microglia/macrophages in gliomas by downregulating ICAM1

Extracellular matrix protein tenascin C increases phagocytosis mediated by CD47 loss of function in glioblastoma

(2019) Shuli Xia et al.   CANCER RESEARCH

The oncometabolite 2-hydroxyglutarate inhibits microglial activation via the AMPK/mTOR/NF-κB pathway

(2019) Chao-jun Han et al.   ACTA PHARMACOLOGICA SINICA

Differential microglia and macrophage profiles in human IDH-mutant and -wild type glioblastoma

(2019) Candice C. Poon et al.   Oncotarget

Analysis of immunobiologic markers in primary and recurrent glioblastoma

(2018) Maryam Rahman et al.   JOURNAL OF NEURO-ONCOLOGY

Suppression of antitumor T cell immunity by the oncometabolite (R)-2-hydroxyglutarate

(2018) Lukas Bunse et al.   NATURE MEDICINE

Heterozygous IDH1R132H/WT created by “single base editing” inhibits human astroglial cell growth by downregulating YAP

(2018) Shuang Wei et al.   ONCOGENE

Targeting UDP-α-d-glucose 6-dehydrogenase inhibits glioblastoma growth and migration

(2018) Olutobi Oyinlade et al.   ONCOGENE

Mutant IDH1 regulates the tumor-associated immune system in gliomas

(2017) Nduka M. Amankulor et al.   GENES & DEVELOPMENT

Correlation of immune phenotype with IDH mutation in diffuse glioma

(2017) Anna Sophie Berghoff et al.   NEURO-ONCOLOGY

β2 Integrins As Regulators of Dendritic Cell, Monocyte, and Macrophage Function

(2017) Leonie Schittenhelm et al.   Frontiers in Immunology

Time lapsein vivomicroscopy reveals distinct dynamics of microglia-tumor environment interactions-a new role for the tumor perivascular space as highway for trafficking microglia

(2016) Simon Heinrich Bayerl et al.   GLIA

Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage

(2016) Alexis C. Komor et al.   NATURE

The role of microglia and macrophages in glioma maintenance and progression

(2016) Dolores Hambardzumyan et al.   NATURE NEUROSCIENCE

Immune checkpoint blockade as a potential therapeutic target: surveying CNS malignancies

(2016) Sarah T. Garber et al.   NEURO-ONCOLOGY

New tools for studying microglia in the mouse and human CNS

(2016) Mariko L. Bennett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rescuing defective tumor-infiltrating T-cell proliferation in glioblastoma patients

(2016) Song Han et al.   Oncology Letters

Single-Cell Co-expression Analysis Reveals Distinct Functional Modules, Co-regulation Mechanisms and Clinical Outcomes

(2016) Jie Wang et al.   PLoS Computational Biology

VEGF Regulates Region-Specific Localization of Perivascular Bone Marrow-Derived Cells in Glioblastoma

(2014) K. Burrell et al.   CANCER RESEARCH

Human macrophage polarization in vitro: Maturation and activation methods compared

(2014) Daphne Y.S. Vogel et al.   IMMUNOBIOLOGY

The Controversial Role of Microglia in Malignant Gliomas

(2013) Jun Wei et al.   Clinical & Developmental Immunology

Integrin inactivators: balancing cellular functions in vitro and in vivo

(2013) Daniel Bouvard et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Disruption of Wild-Type IDH1 Suppresses D-2-Hydroxyglutarate Production in IDH1-Mutated Gliomas

(2012) G. Jin et al.   CANCER RESEARCH

D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function

(2012) M. Sasaki et al.   GENES & DEVELOPMENT

IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype

(2012) Sevin Turcan et al.   NATURE

IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics

(2012) Masato Sasaki et al.   NATURE

EphB2 receptor controls proliferation/migration dichotomy of glioblastoma by interacting with focal adhesion kinase

(2012) S D Wang et al.   ONCOGENE

Glioblastoma: From Molecular Pathology to Targeted Treatment

(2011) Timothy F. Cloughesy et al.   Annual Review of Pathology-Mechanisms of Disease

Glioma cells showing IDH1 mutation cannot be propagated in standard cell culture conditions

(2011) S Piaskowski et al.   BRITISH JOURNAL OF CANCER

Yes-Associated Protein 1 Is Widely Expressed in Human Brain Tumors and Promotes Glioblastoma Growth

(2011) Brent A. Orr et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

2-Hydroxyglutarate Production, but Not Dominant Negative Function, Is Conferred by Glioma-Derived NADP+-Dependent Isocitrate Dehydrogenase Mutations

(2011) Genglin Jin et al.   PLoS One

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

(2009) Lenny Dang et al.   NATURE

IDH1andIDH2Mutations in Gliomas

(2009) Hai Yan et al.   NEW ENGLAND JOURNAL OF MEDICINE