CYLD destabilizes NoxO1 protein by promoting ubiquitination and regulates prostate cancer progression

Genome-scale screening of deubiquitinase subfamily identifies USP3 as a stabilizer of Cdc25A regulating cell cycle in cancer

(2020) Soumyadip Das et al.   CELL DEATH AND DIFFERENTIATION

NF-κB-induced NOX1 activation promotes gastric tumorigenesis through the expansion of SOX2-positive epithelial cells

(2019) Kanae Echizen et al.   ONCOGENE

Deubiquitylating enzymes as cancer stem cell therapeutics

(2018) Saba Haq et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

The stability and oncogenic function of LIN28A are regulated by USP28

(2018) Saba Haq et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Organizers and activators: Cytosolic Nox proteins impacting on vascular function

(2017) Katrin Schröder et al.   FREE RADICAL BIOLOGY AND MEDICINE

NADPH oxidase 1 supports proliferation of colon cancer cells by modulating reactive oxygen species-dependent signal transduction

(2017) Agnes Juhasz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Subcellular localization of the FLT3-ITD oncogene plays a significant role in the production of NOX- and p22phox-derived reactive oxygen species in acute myeloid leukemia

(2017) Jennifer N. Moloney et al.   LEUKEMIA RESEARCH

NADPH Oxidases: Insights into Selected Functions and Mechanisms of Action in Cancer and Stem Cells

(2017) Magdalena Skonieczna et al.   Oxidative Medicine and Cellular Longevity

Deubiquitylation of deubiquitylases

(2017) Saba Haq et al.   Open Biology

The Cytosolic NADPH Oxidase Subunit NoxO1 Promotes an Endothelial Stalk Cell PhenotypeHighlights

(2016) Ralf P. Brandes et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

NADPH Oxidase 1 Activity and ROS Generation Are Regulated by Grb2/Cbl-Mediated Proteasomal Degradation of NoxO1 in Colon Cancer Cells

(2016) J. H. Joo et al.   CANCER RESEARCH

ROS and ROS-Mediated Cellular Signaling

(2016) Jixiang Zhang et al.   Oxidative Medicine and Cellular Longevity

ROS homeostasis and metabolism: a dangerous liason in cancer cells

(2016) E Panieri et al.   Cell Death & Disease

Ubiquitin-specific protease 11 functions as a tumor suppressor by modulating Mgl-1 protein to regulate cancer cell growth

(2016) Key-Hwan Lim et al.   Oncotarget

CYLD-Mediated Signaling and Diseases

(2015) Bryan Mathis et al.   CURRENT DRUG TARGETS

In vitro migration and proliferation (“wound healing”) potential of mesenchymal stromal cells generated from human CD271+ bone marrow mononuclear cells

(2015) Hatixhe Latifi-Pupovci et al.   Journal of Translational Medicine

ROS signaling by NADPH oxidase 5 modulates the proliferation and survival of prostate carcinoma cells

(2015) Monika Höll et al.   MOLECULAR CARCINOGENESIS

Gene disruption by cell-penetrating peptide-mediated delivery of Cas9 protein and guide RNA

(2014) S. Ramakrishna et al.   GENOME RESEARCH

Highly efficient RNA-guided genome editing in human cells via delivery of purified Cas9 ribonucleoproteins

(2014) S. Kim et al.   GENOME RESEARCH

DUOX2 and DUOXA2 Form the Predominant Enzyme System Capable of Producing the Reactive Oxygen Species H2O2 in Active Ulcerative Colitis and are Modulated by 5-Aminosalicylic Acid

(2014) Tammie S. MacFie et al.   INFLAMMATORY BOWEL DISEASES

Oxidative Stress: An Essential Factor in the Pathogenesis of Gastrointestinal Mucosal Diseases

(2014) Asima Bhattacharyya et al.   PHYSIOLOGICAL REVIEWS

Surrogate reporter-based enrichment of cells containing RNA-guided Cas9 nuclease-induced mutations

(2014) Suresh Ramakrishna et al.   Nature Communications

Molecular Mechanisms of the Crosstalk Between Mitochondria and NADPH Oxidase Through Reactive Oxygen Species—Studies in White Blood Cells and in Animal Models

(2013) Swenja Kröller-Schön et al.   ANTIOXIDANTS & REDOX SIGNALING

NADPH Oxidases: A Perspective on Reactive Oxygen Species Production in Tumor Biology

(2013) Jennifer L. Meitzler et al.   ANTIOXIDANTS & REDOX SIGNALING

NOXO1 phosphorylation on serine 154 is critical for optimal NADPH oxidase 1 assembly and activation

(2013) Maya Debbabi et al.   FASEB JOURNAL

Phosphorylation of Noxo1 at threonine 341 regulates its interaction with Noxa1 and the superoxide-producing activity of Nox1

(2013) Asataro Yamamoto et al.   FEBS Journal

Nephropathy and Elevated BP in Mice with Podocyte-Specific NADPH Oxidase 5 Expression

(2013) C. E. Holterman et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Cycles of Ubiquitination and Deubiquitination Critically Regulate Growth Factor-Mediated Activation of Akt Signaling

(2013) W.-L. Yang et al.   Science Signaling

Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling

(2012) Paul D. Ray et al.   CELLULAR SIGNALLING

A crucial role for Nox 1 in redox-dependent regulation of Wnt-β-catenin signaling

(2012) Seheli Kajla et al.   FASEB JOURNAL

CYLD: a deubiquitination enzyme with multiple roles in cancer

(2011) Ramin Massoumi   Future Oncology

The E3 ligase Itch and deubiquitinase Cyld act together to regulate Tak1 and inflammation

(2011) Neesar Ahmed et al.   NATURE IMMUNOLOGY

Deubiquitinases in cancer: new functions and therapeutic options

(2011) J M Fraile et al.   ONCOGENE

NADPH Oxidase NOX1 Controls Autocrine Growth of Liver Tumor Cells through Up-regulation of the Epidermal Growth Factor Receptor Pathway

(2010) Patricia Sancho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of the Tumor Suppressor CYLD Enhances Wnt/β-Catenin Signaling through K63-Linked Ubiquitination of Dvl

(2010) Daniele V.F. Tauriello et al.   MOLECULAR CELL

Regulation of NOXO1 Activity through Reversible Interactions with p22phox and NOXA1

(2010) Sujit Dutta et al.   PLoS One

The Control of the Metabolic Switch in Cancers by Oncogenes and Tumor Suppressor Genes

(2010) A. J. Levine et al.   SCIENCE

Expression of NADPH oxidase homologues and accessory genes in human cancer cell lines, tumours and adjacent normal tissues

(2009) Agnes Juhasz et al.   FREE RADICAL RESEARCH

Targeted genome editing in human cells with zinc finger nucleases constructed via modular assembly

(2009) H. J. Kim et al.   GENOME RESEARCH

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Akt Determines Replicative Senescence and Oxidative or Oncogenic Premature Senescence and Sensitizes Cells to Oxidative Apoptosis

(2008) Veronique Nogueira et al.   CANCER CELL

Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species

(2008) Hideki Sumimoto   FEBS Journal

Tumor necrosis factor α activates transcription of the NADPH oxidase organizer 1 (NOXO1) gene and upregulates superoxide production in colon epithelial cells

(2008) Yuki Kuwano et al.   FREE RADICAL BIOLOGY AND MEDICINE