The allergy mediator histamine confers resistance to immunotherapy in cancer patients via activation of the macrophage histamine receptor H1

Host response to immune checkpoint inhibitors contributes to tumor aggressiveness

(2021) Irina Khononov et al.   Journal for ImmunoTherapy of Cancer

Integrated analysis of multimodal single-cell data

(2021) Yuhan Hao et al.   CELL

Desloratadine and loratadine use associated with improved melanoma survival

(2020) Ildikó Fritz et al.   ALLERGY

Blocking immunosuppressive neutrophils deters pY696-EZH2–driven brain metastases

(2020) Lin Zhang et al.   Science Translational Medicine

Comparison of immune infiltrates in melanoma and pancreatic cancer highlights VISTA as a potential target in pancreatic cancer

(2019) Jorge Blando et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The negative impact of antibiotics on outcomes in cancer patients treated with immunotherapy: a new independent prognostic factor?

(2019) A Elkrief et al.   ANNALS OF ONCOLOGY

PD-1 blockade in subprimed CD8 cells induces dysfunctional PD-1+CD38hi cells and anti-PD-1 resistance

(2019) Vivek Verma et al.   NATURE IMMUNOLOGY

Macrophage Polarization: Different Gene Signatures in M1(LPS+) vs. Classically and M2(LPS–) vs. Alternatively Activated Macrophages

(2019) Marco Orecchioni et al.   Frontiers in Immunology

VISTA is an acidic pH-selective ligand for PSGL-1

(2019) Robert J. Johnston et al.   NATURE

Cancer immunotherapy using checkpoint blockade

(2018) Antoni Ribas et al.   SCIENCE

Macrophages: The Road Less Traveled, Changing Anticancer Therapy

(2018) Jennifer L. Guerriero   TRENDS IN MOLECULAR MEDICINE

Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response

(2018) Peng Jiang et al.   NATURE MEDICINE

OUP accepted manuscript

(2018)   NUCLEIC ACIDS RESEARCH

Histamine causes endothelial barrier disruption via Ca2+-mediated RhoA activation and tension at adherens junctions

(2018) Daniela Kugelmann et al.   Scientific Reports

Histamine receptors and cancer pharmacology: an update

(2018) Noelia A Massari et al.   BRITISH JOURNAL OF PHARMACOLOGY

Histamine targets myeloid-derived suppressor cells and improves the anti-tumor efficacy of PD-1/PD-L1 checkpoint blockade

(2018) Hanna Grauers Wiktorin et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade

(2018) Livnat Jerby-Arnon et al.   CELL

Transcriptional profiling identifies novel regulators of macrophage polarization

(2018) Kimberline Y. Gerrick et al.   PLoS One

Immunoregulatory functions of VISTA

(2017) Elizabeth C. Nowak et al.   IMMUNOLOGICAL REVIEWS

Antihistamines as promising drugs in cancer therapy

(2017) Ana I. Faustino-Rocha et al.   LIFE SCIENCES

VISTA is an inhibitory immune checkpoint that is increased after ipilimumab therapy in patients with prostate cancer

(2017) Jianjun Gao et al.   NATURE MEDICINE

A pathology atlas of the human cancer transcriptome

(2017) Mathias Uhlen et al.   SCIENCE

Massively parallel digital transcriptional profiling of single cells

(2017) Grace X. Y. Zheng et al.   Nature Communications

Genomic and Transcriptomic Features of Response to Anti-PD-1 Therapy in Metastatic Melanoma

(2016) Willy Hugo et al.   CELL

Overcoming resistance to checkpoint blockade therapy by targeting PI3Kγ in myeloid cells

(2016) Olivier De Henau et al.   NATURE

Rational Selection of Syngeneic Preclinical Tumor Models for Immunotherapeutic Drug Discovery

(2016) Suzanne I.S. Mosely et al.   Cancer Immunology Research

TIM-3 Regulates Distinct Functions in Macrophages

(2016) Ranferi Ocaña-Guzman et al.   Frontiers in Immunology

Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity

(2015) Santiago Zelenay et al.   CELL

Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth

(2015) Lin Zhang et al.   NATURE

Robust enumeration of cell subsets from tissue expression profiles

(2015) Aaron M Newman et al.   NATURE METHODS

Histamine Induces Vascular Hyperpermeability by Increasing Blood Flow and Endothelial Barrier Disruption In Vivo

(2015) Kohei Ashina et al.   PLoS One

Immune-checkpoint proteins VISTA and PD-1 nonredundantly regulate murine T-cell responses

(2015) Jun Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Macrophages and cancer: from mechanisms to therapeutic implications

(2015) Renato Ostuni et al.   TRENDS IN IMMUNOLOGY

Novel Markers to Delineate Murine M1 and M2 Macrophages

(2015) Kyle A. Jablonski et al.   PLoS One

VISTA Is an Immune Checkpoint Molecule for Human T Cells

(2014) J. L. Lines et al.   CANCER RESEARCH

VISTA Regulates the Development of Protective Antitumor Immunity

(2014) I. Le Mercier et al.   CANCER RESEARCH

Mast cell histamine promotes the immunoregulatory activity of myeloid-derived suppressor cells

(2014) Rebecca K. Martin et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression

(2014) Limo Chen et al.   Nature Communications

Flow Cytometric Analysis of Macrophages and Dendritic Cell Subsets in the Mouse Lung

(2013) Alexander V. Misharin et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Relationship between Allergy and Cancer: An Overview

(2012) Delia Rittmeyer et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Identification of Common Prognostic Gene Expression Signatures with Biological Meanings from Microarray Gene Expression Datasets

(2012) Jun Yao et al.   PLoS One

The Role of Calcium in Intracellular Trafficking

(2010) M. Micaroni   CURRENT MOLECULAR MEDICINE

Histamine deficiency promotes inflammation-associated carcinogenesis through reduced myeloid maturation and accumulation of CD11b+Ly6G+ immature myeloid cells

(2010) Xiang Dong Yang et al.   NATURE MEDICINE

Endothelial histamine H1 receptor signaling reduces blood-brain barrier permeability and susceptibility to autoimmune encephalomyelitis

(2010) C. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolism of histamine in tissues of primary ductal breast cancer

(2009) Jarosław von Mach-Szczypiński et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

The “Classical” Ovalbumin Challenge Model of Asthma in Mice

(2008) Rakesh Kumar et al.   CURRENT DRUG TARGETS

Mouse models of allergic asthma: acute and chronic allergen challenge

(2008) A. T. Nials et al.   Disease Models & Mechanisms

The role of histamine H1 and H4 receptors in allergic inflammation: the search for new antihistamines

(2008) Robin L. Thurmond et al.   NATURE REVIEWS DRUG DISCOVERY

Histamine and its receptors

(2006) Mike E Parsons et al.   BRITISH JOURNAL OF PHARMACOLOGY