The role of the ubiquitin-proteasome pathway in skin cancer development: 26S proteasome-activated NF-κB signal transduction

Antitumor Effect of Inula viscosa Extracts on DMBA-Induced Skin Carcinoma Are Mediated by Proteasome Inhibition

(2021) Ouadie Mohamed El Yaagoubi et al.   Biomed Research International

Overcoming resistance to BRAFV600E inhibition in melanoma by deciphering and targeting personalized protein network alterations

(2021) S. Vasudevan et al.   npj Precision Oncology

NF-κB and Human Cancer: What Have We Learned over the Past 35 Years?

(2021) Thomas D. Gilmore   Biomedicines

It's time for Mohs : Micrographic surgery for the treatment of high‐risk basal cell carcinomas of the head and neck regions

(2020) Emi Dika et al.   Dermatologic Therapy

Proteomic analyses reveal divergent ubiquitylation patterns in hepatocellula carcinoma cell lines with different metastasis potential

(2020) Ying Sun et al.   Journal of Proteomics

Stat2 stability regulation: an intersection between immunity and carcinogenesis

(2020) Cheol-Jung Lee et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Inhibition of proteasome reveals basal mitochondrial ubiquitination

(2020) Prasad Sulkshane et al.   Journal of Proteomics

Proteomic approaches for the profiling of ubiquitylation events and their applications in drug discovery

(2020) Zhanhong Hu et al.   Journal of Proteomics

Repurposing old drugs as new inhibitors of the ubiquitin-proteasome pathway for cancer treatment

(2019) Huanjie Yang et al.   SEMINARS IN CANCER BIOLOGY

Targeting Ubiquitin-proteasome pathway by natural, in particular polyphenols, anticancer agents: lessons learned from clinical trials

(2018) Seyed Fazel Nabavi et al.   CANCER LETTERS

Roles of UVA radiation and DNA damage responses in melanoma pathogenesis

(2018) Aiman Q. Khan et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Next-generation proteasome inhibitors for cancer therapy

(2018) Ji Eun Park et al.   Translational Research

Preclinical comparison of proteasome and ubiquitin E1 enzyme inhibitors in cutaneous squamous cell carcinoma: the identification of mechanisms of differential sensitivity

(2018) Angela McHugh et al.   Oncotarget

Microenvironment-Driven Dynamic Heterogeneity and Phenotypic Plasticity as a Mechanism of Melanoma Therapy Resistance

(2018) Farzana Ahmed et al.   Frontiers in Oncology

Toxic Side Effects of Targeted Therapies and Immunotherapies Affecting the Skin, Oral Mucosa, Hair, and Nails

(2018) Mario Lacouture et al.   AMERICAN JOURNAL OF CLINICAL DERMATOLOGY

Microphthalmia-Associated Transcription Factor (MITF) Regulates Immune Cell Migration into Melanoma

(2018) Gabriela M Wiedemann et al.   Translational Oncology

The proteasome maturation protein POMP increases proteasome assembly and activity in psoriatic lesional skin

(2017) Barbara A. Zieba et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Interferon-gamma activity is potentiated by an intracellular peptide derived from the human 19S ATPase regulatory subunit 4 of the proteasome

(2017) Elisabete R.C. Monte et al.   Journal of Proteomics

Diet phytochemicals and cutaneous carcinoma chemoprevention: A review

(2017) Siliang Wang et al.   PHARMACOLOGICAL RESEARCH

Proteasome inhibitors: structure and function

(2017) Ana T. Nunes et al.   SEMINARS IN ONCOLOGY

Curcumin-loaded layer-by-layer folic acid and casein coated carboxymethyl cellulose/casein nanogels for treatment of skin cancer

(2017) P. Priya et al.   Arabian Journal of Chemistry

Interferon Regulatory Factor 6 Controls Proliferation of Keratinocytes from Children with Van der Woude Syndrome

(2017) Katherine Hixon et al.   CLEFT PALATE-CRANIOFACIAL JOURNAL

Ubiquitination in melanoma pathogenesis and treatment

(2017) Jinyuan Ma et al.   Cancer Medicine

The Promise of Genomics and the Development of Targeted Therapies for Cutaneous Squamous Cell Carcinoma

(2016) C Harwood et al.   ACTA DERMATO-VENEREOLOGICA

Cancer treatment and survivorship statistics, 2016

(2016) Kimberly D. Miller et al.   CA-A CANCER JOURNAL FOR CLINICIANS

N-Myristoylation of the Rpt2 subunit of the yeast 26S proteasome is implicated in the subcellular compartment-specific protein quality control system

(2016) Ayuko Kimura et al.   Journal of Proteomics

Biological significance of co- and post-translational modifications of the yeast 26S proteasome

(2016) Hisashi Hirano et al.   Journal of Proteomics

Tumors overexpressing RNF168 show altered DNA repair and responses to genotoxic treatments, genomic instability and resistance to proteotoxic stress

(2016) K Chroma et al.   ONCOGENE

The state of melanoma: challenges and opportunities

(2016) Glenn Merlino et al.   Pigment Cell & Melanoma Research

NF-κB activation in chronic lymphocytic leukemia: A point of convergence of external triggers and intrinsic lesions

(2016) Larry Mansouri et al.   SEMINARS IN CANCER BIOLOGY

Basal cell carcinoma, squamous cell carcinoma and melanoma of the head and face

(2016) L. Feller et al.   Head & Face Medicine

Proteasome inhibitors

(2015) Beverly A. Teicher et al.   BIOCHEMICAL PHARMACOLOGY

Engineered in-situ depot-forming hydrogels for intratumoral drug delivery

(2015) Amir Fakhari et al.   JOURNAL OF CONTROLLED RELEASE

Epidermal p65/NF- B signalling is essential for skin carcinogenesis

(2014) C. Kim et al.   EMBO Molecular Medicine

Novel Targeted Agents in the Treatment of Multiple Myeloma

(2014) Cindy Varga et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Towards combinatorial targeted therapy in melanoma: From pre-clinical evidence to clinical application (Review)

(2014) GIULIA GRAZIA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Biodistribution and Efficacy Studies of the Proteasome Inhibitor BSc2118 in a Mouse Melanoma Model

(2014) Izabela Mlynarczuk-Bialy et al.   Translational Oncology

Protein quality control and elimination of protein waste: The role of the ubiquitin–proteasome system

(2013) Ingo Amm et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Regulation of proteasome activity in health and disease

(2013) Marion Schmidt et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Molecular mechanisms underlying chronic inflammation-associated cancers

(2013) Yongzhong Wu et al.   CANCER LETTERS

Role of SKP1-CUL1-F-Box-Protein (SCF) E3 Ubiquitin Ligases in Skin Cancer

(2013) Chuan-Ming Xie et al.   Journal of Genetics and Genomics

Cutaneous squamous cell carcinoma: Estimated incidence of disease, nodal metastasis, and deaths from disease in the United States, 2012

(2013) Pritesh S. Karia et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Targeting Notch signaling pathway in cancer: Clinical development advances and challenges

(2013) Naoko Takebe et al.   PHARMACOLOGY & THERAPEUTICS

Impact of Sunscreens on Preventing UVR-Induced Effects in Nevi

(2013) Cristina Carrera et al.   JAMA Dermatology

Bortezomib/proteasome inhibitor triggers both apoptosis and autophagy-dependent pathways in melanoma cells

(2012) Denis Selimovic et al.   CELLULAR SIGNALLING

Resistance to Chemotherapy and Molecularly Targeted Therapies: Rationale for Combination Therapy in Malignant Melanoma

(2012) S. Wu et al.   CURRENT MOLECULAR MEDICINE

Emerging avenues linking inflammation and cancer

(2012) Joydeb Kumar Kundu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Melanoma: from mutations to medicine

(2012) H. Tsao et al.   GENES & DEVELOPMENT

NF-κB: An essential transcription factor in psoriasis

(2012) A.M. Goldminz et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Melanoma: New Insights and New Therapies

(2012) Vasiliki A. Nikolaou et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Frequency and Spectrum of BRAF Mutations in a Retrospective, Single-Institution Study of 1112 Cases of Melanoma

(2012) Wesley O. Greaves et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

NF-κB as potential target in the treatment of melanoma

(2012) Gabriele Madonna et al.   Journal of Translational Medicine

Survival in BRAF V600–Mutant Advanced Melanoma Treated with Vemurafenib

(2012) Jeffrey A. Sosman et al.   NEW ENGLAND JOURNAL OF MEDICINE

The 26S proteasome complex: An attractive target for cancer therapy

(2011) Sarah Frankland-Searby et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

SCF E3 Ubiquitin Ligases as Anticancer Targets

(2011) L. Jia et al.   CURRENT CANCER DRUG TARGETS

Integrative analysis of the ubiquitin proteome isolated using Tandem Ubiquitin Binding Entities (TUBEs)

(2011) Fernando Lopitz-Otsoa et al.   Journal of Proteomics

Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation

(2011) Paul B. Chapman et al.   NEW ENGLAND JOURNAL OF MEDICINE

NF-κB inducing kinase (NIK) modulates melanoma tumorigenesis by regulating expression of pro-survival factors through the β-catenin pathway

(2011) Y M Thu et al.   ONCOGENE

ABT-737 synergizes with Bortezomib to kill melanoma cells

(2011) S. N. Reuland et al.   Biology Open

Proteasome inhibitors in cancer therapy

(2011) Lisa J. Crawford et al.   Journal of Cell Communication and Signaling

Structure characterization of the 26S proteasome

(2010) Ho Min Kim et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

Growth and progression of melanoma and non-melanoma skin cancers regulated by ubiquitination

(2010) Koh Nakayama   Pigment Cell & Melanoma Research

The proteasomal system

(2009) Tobias Jung et al.   MOLECULAR ASPECTS OF MEDICINE

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

(2009) Teresa A. Soucy et al.   NATURE

Increased proteasome subunit protein expression and proteasome activity in colon cancer relate to an enhanced activation of nuclear factor E2-related factor 2 (Nrf2)

(2009) A Arlt et al.   ONCOGENE

The proteasome: Overview of structure and functions

(2009) Keiji TANAKA   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

The Anti-Cancer Activity of Noscapine: A Review

(2009) Massoud Mahmoudian et al.   Recent Patents on Anti-Cancer Drug Discovery

Evodiamine-induced human melanoma A375-S2 cell death was mediated by PI3K/Akt/caspase and Fas-L/NF-κB signaling pathways and augmented by ubiquitin–proteasome inhibition

(2009) Che Wang et al.   TOXICOLOGY IN VITRO

The NF- B Family of Transcription Factors and Its Regulation

(2009) A. Oeckinghaus et al.   Cold Spring Harbor Perspectives in Biology

Targeting Proteins for Destruction by the Ubiquitin System: Implications for Human Pathobiology

(2008) Alan L. Schwartz et al.   Annual Review of Pharmacology and Toxicology

Effect of proteasome inhibitors on proliferation and apoptosis of human cutaneous melanoma-derived cell lines

(2008) A. Sorolla et al.   BRITISH JOURNAL OF DERMATOLOGY

IFN-  and Bortezomib Overcome Bcl-2 and Mcl-1 Overexpression in Melanoma Cells by Stimulating the Extrinsic Pathway of Apoptosis

(2008) G. B. Lesinski et al.   CANCER RESEARCH

Targeted therapy for uveal melanoma

(2008) Pierre L. Triozzi et al.   CANCER TREATMENT REVIEWS

The FoxO3a gene is a key negative target of canonical Notch signalling in the keratinocyte UVB response

(2008) Anna Mandinova et al.   EMBO JOURNAL

The Two-Faced NF-κB in the Skin

(2008) Inderpreet Sur et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Epidermolysis bullosa and the risk of life-threatening cancers: The National EB Registry experience, 1986-2006

(2008) Jo-David Fine et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Cancer-related inflammation

(2008) Alberto Mantovani et al.   NATURE

Is NF-κB a good target for cancer therapy? Hopes and pitfalls

(2008) Véronique Baud et al.   NATURE REVIEWS DRUG DISCOVERY