Exercise protects from hippocampal inflammation and neurodegeneration in experimental autoimmune encephalomyelitis

CSF parvalbumin levels reflect interneuron loss linked with cortical pathology in multiple sclerosis

(2021) Roberta Magliozzi et al.   Annals of Clinical and Translational Neurology

High-Intensity Exercise Training Protects the Brain Against Autoimmune Neuroinflammation: Regulation of Microglial Redox and Pro-inflammatory Functions

(2021) Yifat Zaychik et al.   Frontiers in Cellular Neuroscience

Complement-dependent synapse loss and microgliosis in a mouse model of multiple sclerosis

(2020) Jennetta W. Hammond et al.   BRAIN BEHAVIOR AND IMMUNITY

Antidepressant-like and pro-neurogenic effects of physical exercise: the putative role of FNDC5/irisin pathway

(2020) Aline Siteneski et al.   JOURNAL OF NEURAL TRANSMISSION

Transient upregulation of translational efficiency in prodromal and early symptomatic Tg2576 mice contributes to Aβ pathology

(2020) Antonella Borreca et al.   NEUROBIOLOGY OF DISEASE

Voluntary running does not reduce neuroinflammation or improve non-cognitive behavior in the 5xFAD mouse model of Alzheimer’s disease

(2020) Martina Svensson et al.   Scientific Reports

Moving exercise research in multiple sclerosis forward (the MoXFo initiative): Developing consensus statements for research

(2020) Ulrik Dalgas et al.   Multiple Sclerosis Journal

Exercise training and cognitive performance in persons with multiple sclerosis: A systematic review and multilevel meta-analysis of clinical trials

(2020) Reza Gharakhanlou et al.   Multiple Sclerosis Journal

Astrocyte remodeling in the beneficial effects of long-term voluntary exercise in Alzheimer’s disease

(2020) Irina Belaya et al.   Journal of Neuroinflammation

Diffusible Tumor Necrosis Factor-Alpha (TNF-α) Promotes Noise-Induced Parvalbumin-Positive (PV+) Neuron Loss and Auditory Processing Impairments

(2020) Di Deng et al.   Frontiers in Neuroscience

The role of hippocampal theta oscillations in working memory impairment in multiple sclerosis

(2020) Lars Costers et al.   HUMAN BRAIN MAPPING

Talking About Physical “Activity” or “Inactivity”? The Need of Accurate Activity Controlling in Exercise Studies in Rodents

(2020) Niklas Joisten et al.   Frontiers in Physiology

High dose of dexamethasone protects against EAE-induced motor deficits but impairs learning/memory in C57BL/6 mice

(2019) Nilton dos Santos et al.   Scientific Reports

Voluntary running wheel attenuates motor deterioration and brain damage in cuprizone-induced demyelination

(2019) Georgia Mandolesi et al.   NEUROBIOLOGY OF DISEASE

Inducing Physical Inactivity in Mice: Preventing Climbing and Reducing Cage Size Negatively Affect Physical Fitness and Body Composition

(2019) Peter Roemers et al.   Frontiers in Behavioral Neuroscience

Exercise training attenuates experimental autoimmune encephalomyelitis by peripheral immunomodulation rather than direct neuroprotection

(2018) Ofira Einstein et al.   EXPERIMENTAL NEUROLOGY

Regional hippocampal vulnerability in early multiple sclerosis: Dynamic pathological spreading from dentate gyrus to CA1

(2018) Vincent Planche et al.   HUMAN BRAIN MAPPING

Blocking Tumor Necrosis Factor-Alpha Expression Prevents Blast-Induced Excitatory/Inhibitory Synaptic Imbalance and Parvalbumin-Positive Interneuron Loss in the Hippocampus

(2018) Weihua Wang et al.   JOURNAL OF NEUROTRAUMA

Microglial activation and the nitric oxide/cGMP/PKG pathway underlie enhanced neuronal vulnerability to mitochondrial dysfunction in experimental multiple sclerosis

(2018) Andrea Mancini et al.   NEUROBIOLOGY OF DISEASE

Running exercise mitigates the negative consequences of chronic stress on dorsal hippocampal long-term potentiation in male mice

(2018) Roxanne M. Miller et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Nest-building activity as a reproducible and long-term stroke deficit test in a mouse model of stroke

(2018) Dong Yuan et al.   Brain and Behavior

The hippocampus in multiple sclerosis

(2018) Maria A Rocca et al.   LANCET NEUROLOGY

Multiple sclerosis and cognition: synaptic failure and network dysfunction

(2018) Massimiliano Di Filippo et al.   NATURE REVIEWS NEUROSCIENCE

Effects of moderate- versus high- intensity swimming training on inflammatory and CD4+ T cell subset profiles in experimental autoimmune encephalomyelitis mice

(2018) Yu Xie et al.   JOURNAL OF NEUROIMMUNOLOGY

Voluntary wheel running differentially affects disease outcomes in male and female mice with experimental autoimmune encephalomyelitis

(2017) Katherine A. Mifflin et al.   JOURNAL OF NEUROIMMUNOLOGY

Viewpoints: how the hippocampus contributes to memory, navigation and cognition

(2017) John Lisman et al.   NATURE NEUROSCIENCE

Regular exercise promotes memory function and enhances hippocampal neuroplasticity in experimental autoimmune encephalomyelitis mice

(2017) Tae-Woon Kim et al.   NEUROSCIENCE

On the Run for Hippocampal Plasticity

(2017) C’iana Cooper et al.   Cold Spring Harbor Perspectives in Medicine

Voluntary Exercise Promotes Glymphatic Clearance of Amyloid Beta and Reduces the Activation of Astrocytes and Microglia in Aged Mice

(2017) Xiao-fei He et al.   Frontiers in Molecular Neuroscience

Hippocampal Neuroinflammation, Functional Connectivity, and Depressive Symptoms in Multiple Sclerosis

(2016) Alessandro Colasanti et al.   BIOLOGICAL PSYCHIATRY

Siponimod (BAF312) prevents synaptic neurodegeneration in experimental multiple sclerosis

(2016) Antonietta Gentile et al.   Journal of Neuroinflammation

Physical Exercise Attenuates Experimental Autoimmune Encephalomyelitis by Inhibiting Peripheral Immune Response and Blood-Brain Barrier Disruption

(2016) Priscila S. Souza et al.   MOLECULAR NEUROBIOLOGY

Neuroinflammatory TNFα Impairs Memory via Astrocyte Signaling

(2015) Samia Habbas et al.   CELL

Synaptopathy connects inflammation and neurodegeneration in multiple sclerosis

(2015) Georgia Mandolesi et al.   Nature Reviews Neurology

Dopaminergic dysfunction is associated with IL-1β-dependent mood alterations in experimental autoimmune encephalomyelitis

(2015) Antonietta Gentile et al.   NEUROBIOLOGY OF DISEASE

Hippocampal function is compromised in an animal model of multiple sclerosis

(2015) T. Novkovic et al.   NEUROSCIENCE

Exploring the role of microglia in mood disorders associated with experimental multiple sclerosis

(2015) Antonietta Gentile et al.   Frontiers in Cellular Neuroscience

The Corticohippocampal Circuit, Synaptic Plasticity, and Memory

(2015) Jayeeta Basu et al.   Cold Spring Harbor Perspectives in Biology

Microglial response to Alzheimer’s disease is differentially modulated by voluntary wheel running and enriched environments

(2013) J. J. Rodríguez et al.   Brain Structure & Function

Changes in nociceptive sensitivity and object recognition in experimental autoimmune encephalomyelitis (EAE)

(2013) Camille J. Olechowski et al.   EXPERIMENTAL NEUROLOGY

Interleukin-1β Promotes Long-Term Potentiation in Patients with Multiple Sclerosis

(2013) Francesco Mori et al.   NEUROMOLECULAR MEDICINE

Inflammation Subverts Hippocampal Synaptic Plasticity in Experimental Multiple Sclerosis

(2013) Robert Nisticò et al.   PLoS One

Therapeutic Testosterone Administration Preserves Excitatory Synaptic Transmission in the Hippocampus during Autoimmune Demyelinating Disease

(2012) M. O. Ziehn et al.   JOURNAL OF NEUROSCIENCE

In vivo voxel based morphometry: Detection of increased hippocampal volume and decreased glutamate levels in exercising mice

(2012) Sarah Biedermann et al.   NEUROIMAGE

The increasing incidence and prevalence of female multiple sclerosis—A critical analysis of potential environmental factors

(2011) Johann Sellner et al.   AUTOIMMUNITY REVIEWS

Lack of cyclin D2 impairing adult brain neurogenesis alters hippocampal-dependent behavioral tasks without reducing learning ability

(2011) Paulina Jedynak et al.   BEHAVIOURAL BRAIN RESEARCH

Wheel running attenuates microglia proliferation and increases expression of a proneurogenic phenotype in the hippocampus of aged mice

(2011) Rachel A. Kohman et al.   BRAIN BEHAVIOR AND IMMUNITY

Exercise training increases size of hippocampus and improves memory

(2011) K. I. Erickson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Demyelination causes synaptic alterations in hippocampi from multiple sclerosis patients

(2010) Ranjan Dutta et al.   ANNALS OF NEUROLOGY

Hippocampal CA1 atrophy and synaptic loss during experimental autoimmune encephalomyelitis, EAE

(2010) Marina O Ziehn et al.   LABORATORY INVESTIGATION

Running enhances spatial pattern separation in mice

(2010) D. J. Creer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Age-related cognitive decline and nesting behavior in an APPswe/PS1 bigenic model of Alzheimer's disease

(2009) Mohammed Filali et al.   BRAIN RESEARCH

Exercise attenuates the clinical, synaptic and dendritic abnormalities of experimental autoimmune encephalomyelitis

(2009) Silvia Rossi et al.   NEUROBIOLOGY OF DISEASE

Exercise alters the immune profile in Tg2576 Alzheimer mice toward a response coincident with improved cognitive performance and decreased amyloid

(2008) Kathryn E Nichol et al.   Journal of Neuroinflammation

Distribution of parvalbumin and calretinin immunoreactive interneurons in motor cortex from multiple sclerosis post-mortem tissue

(2008) Robert J. Clements et al.   EXPERIMENTAL BRAIN RESEARCH