The Wnt pathway: An important control mechanism in bone's response to mechanical loading

A FAK/HDAC5 signaling axis controls osteocyte mechanotransduction

(2020) Tadatoshi Sato et al.   Nature Communications

Trends in Sedentary Behavior Among the US Population, 2001-2016

(2019) Lin Yang et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Wnt Signaling–Related Osteokines at Rest and Following Plyometric Exercise in Prepubertal and Early Pubertal Boys and Girls

(2018) Panagiota Klentrou et al.   PEDIATRIC EXERCISE SCIENCE

R-spondins can potentiate WNT signaling without LGRs

(2018) Andres M Lebensohn et al.   eLife

RSPO2 inhibition of RNF43 and ZNRF3 governs limb development independently of LGR4/5/6

(2018) Emmanuelle Szenker-Ravi et al.   NATURE

Evidence of the Role of R-Spondin 1 and Its Receptor Lgr4 in the Transmission of Mechanical Stimuli to Biological Signals for Bone Formation

(2017) Gui-Xun Shi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The co-existence of transcriptional activator and transcriptional repressor MEF2 complexes influences tumor aggressiveness

(2017) Eros Di Giorgio et al.   PLoS Genetics

Sost deficiency led to a greater cortical bone formation response to mechanical loading and altered gene expression

(2017) David Pflanz et al.   Scientific Reports

Postnatal β-catenin deletion from Dmp1-expressing osteocytes/osteoblasts reduces structural adaptation to loading, but not periosteal load-induced bone formation

(2016) Kyung Shin Kang et al.   BONE

Activation of Wnt Signaling by Mechanical Loading Is Impaired in the Bone of Old Mice

(2016) Nilsson Holguin et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Regulation of class IIa HDAC activities: it is not only matter of subcellular localization

(2016) Eros Di Giorgio et al.   Epigenomics

In vivo mechanical loading rapidly activates β-catenin signaling in osteocytes through a prostaglandin mediated mechanism

(2015) N. Lara-Castillo et al.   BONE

HDAC5 Controls MEF2C-Driven Sclerostin Expression in Osteocytes

(2015) Marc N Wein et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Deletion of a Single β-Catenin Allele in Osteocytes Abolishes the Bone Anabolic Response to Loading

(2013) Behzad Javaheri et al.   JOURNAL OF BONE AND MINERAL RESEARCH

R-spondin 1 promotes vibration-induced bone formation in mouse models of osteoporosis

(2013) Haitao Wang et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Mechanotransduction in bone tissue: The A214V and G171V mutations in Lrp5 enhance load-induced osteogenesis in a surface-selective manner

(2012) Paul J. Niziolek et al.   BONE

Loss of wnt/β-catenin signaling causes cell fate shift of preosteoblasts from osteoblasts to adipocytes

(2012) Lige Song et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Focal Adhesion Kinase Plays a Role in Osteoblast Mechanotransduction In Vitro but Does Not Affect Load-Induced Bone Formation In Vivo

(2012) Alesha B. Castillo et al.   PLoS One

Targeted deletion of Sost distal enhancer increases bone formation and bone mass

(2012) N. M. Collette et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Analysis of multiple bone responses to graded strains above functional levels, and to disuse, in mice in vivo show that the human Lrp5 G171V High Bone Mass mutation increases the osteogenic response to loading but that lack of Lrp5 activity reduces it

(2011) Leanne K. Saxon et al.   BONE

Sost downregulation and local Wnt signaling are required for the osteogenic response to mechanical loading

(2011) Xiaolin Tu et al.   BONE

Alternative splicing in bone following mechanical loading

(2010) Sara M. Mantila Roosa et al.   BONE

Gene expression patterns in bone following mechanical loading

(2010) Sara M Mantila Roosa et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Osteocytes, mechanosensing and Wnt signaling

(2008) Lynda F. Bonewald et al.   BONE

The Binding Between Sclerostin and LRP5 is Altered by DKK1 and by High-Bone Mass LRP5 Mutations

(2008) Wendy Balemans et al.   CALCIFIED TISSUE INTERNATIONAL

Characterization of the Kremen-binding Site on Dkk1 and Elucidation of the Role of Kremen in Dkk-mediated Wnt Antagonism

(2008) Ke Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeted Deletion of the Sclerostin Gene in Mice Results in Increased Bone Formation and Bone Strength

(2008) Xiaodong Li et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Where Wnts Went: The Exploding Field of Lrp5 and Lrp6 Signaling in Bone

(2008) Bart O Williams et al.   JOURNAL OF BONE AND MINERAL RESEARCH