Epigenetic landscape of drug responses revealed through large-scale ChIP-seq data analyses

First-in-human Phase 1 open label study of the BET inhibitor ODM-207 in patients with selected solid tumours

(2020) Malaka Ameratunga et al.   BRITISH JOURNAL OF CANCER

Large scale comparison of QSAR and conformal prediction methods and their applications in drug discovery

(2019) Nicolas Bosc et al.   Journal of Cheminformatics

Valproic acid exhibits anti-tumor activity selectively against EGFR/ErbB2/ErbB3-coexpressing pancreatic cancer via induction of ErbB family members-targeting microRNAs

(2019) Tingting Lin et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Leflunomide Synergizes with Gemcitabine in Growth Inhibition of Pancreatic Cancer Cells and Impairs c-Myc Signaling through PIM Kinase Targeting

(2019) Ralf Buettner et al.   Molecular Therapy-Oncolytics

The DisGeNET knowledge platform for disease genomics: 2019 update

(2019) Janet Piñero et al.   NUCLEIC ACIDS RESEARCH

JASPAR 2020: update of the open-access database of transcription factor binding profiles

(2019) Oriol Fornes et al.   NUCLEIC ACIDS RESEARCH

HIF1α inhibition facilitates Leflunomide-AHR-CRP signaling to attenuate bone erosion in CRP-aberrant rheumatoid arthritis

(2019) Chao Liang et al.   Nature Communications

Targeting of TLE3 by miR‑3677 in human breast cancer promotes cell proliferation, migration and invasion

(2019) Li‑Na Peng et al.   Oncology Letters

Phase I/II intra-patient dose escalation study of vorinostat in children with relapsed solid tumor, lymphoma, or leukemia

(2019) Cornelis M. van Tilburg et al.   Clinical Epigenetics

Phase Ib Trial With Birabresib, a Small-Molecule Inhibitor of Bromodomain and Extraterminal Proteins, in Patients With Selected Advanced Solid Tumors

(2018) Jeremy Lewin et al.   JOURNAL OF CLINICAL ONCOLOGY

Ferroptosis: A Novel Anti-tumor Action for Cisplatin

(2018) Jipeng Guo et al.   Cancer Research and Treatment

The Comparative Toxicogenomics Database: update 2019

(2018) Allan Peter Davis et al.   NUCLEIC ACIDS RESEARCH

Valproic acid and epilepsy: from molecular mechanisms to clinical evidences

(2018) Michele Romoli et al.   Current Neuropharmacology

ChIP‐Atlas: a data‐mining suite powered by full integration of public ChIP‐seq data

(2018) Shinya Oki et al.   EMBO REPORTS

Leflunomide inhibits proliferation and tumorigenesis of oral squamous cell carcinoma

(2017) Aishu Ren et al.   Molecular Medicine Reports

Retinoic acid receptor alpha drives cell cycle progression and is associated with increased sensitivity to retinoids in T-cell lymphoma

(2017) Xueju Wang et al.   Oncotarget

TLE3 represses colorectal cancer proliferation by inhibiting MAPK and AKT signaling pathways

(2016) Run-Wei Yang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

CHD8 haploinsufficiency results in autistic-like phenotypes in mice

(2016) Yuta Katayama et al.   NATURE

Analysis of computational footprinting methods for DNase sequencing experiments

(2016) Eduardo G Gusmao et al.   NATURE METHODS

Extraction and analysis of signatures from the Gene Expression Omnibus by the crowd

(2016) Zichen Wang et al.   Nature Communications

Tumor-Suppressor Functions of the TP53 Pathway

(2016) Brandon J. Aubrey et al.   Cold Spring Harbor Perspectives in Medicine

Roles of NF-κB in Cancer and Inflammatory Diseases and Their Therapeutic Approaches

(2016) Mi Park et al.   Cells

Chemopreventive effect of leflunomide against Ehrlich's solid tumor grown in mice: Effect on EGF and EGFR expression and tumor proliferation

(2015) Hoda I. Bahr et al.   LIFE SCIENCES

Novel Drug Candidates for the Treatment of Metastatic Colorectal Cancer through Global Inverse Gene-Expression Profiling

(2014) V. van Noort et al.   CANCER RESEARCH

ISMARA: automated modeling of genomic signals as a democracy of regulatory motifs

(2014) P. J. Balwierz et al.   GENOME RESEARCH

Open TG-GATEs: a large-scale toxicogenomics database

(2014) Yoshinobu Igarashi et al.   NUCLEIC ACIDS RESEARCH

LINCS Canvas Browser: interactive web app to query, browse and interrogate LINCS L1000 gene expression signatures

(2014) Qiaonan Duan et al.   NUCLEIC ACIDS RESEARCH

Systematic evaluation of connectivity map for disease indications

(2014) Jie Cheng et al.   Genome Medicine

Identification of drug candidate against prostate cancer from the aspect of somatic cell reprogramming

(2013) Takeo Kosaka et al.   CANCER SCIENCE

Transcriptional network of androgen receptor in prostate cancer progression

(2013) Ken-ichi Takayama et al.   INTERNATIONAL JOURNAL OF UROLOGY

Prenatal Valproate Exposure and Risk of Autism Spectrum Disorders and Childhood Autism

(2013) Jakob Christensen et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Leflunomide Reduces Proliferation and Induces Apoptosis in Neuroblastoma Cells In Vitro and In Vivo

(2013) Shunqin Zhu et al.   PLoS One

Sequencing Chromosomal Abnormalities Reveals Neurodevelopmental Loci that Confer Risk across Diagnostic Boundaries

(2012) Michael E. Talkowski et al.   CELL

MYC on the Path to Cancer

(2012) Chi V. Dang   CELL

QSAR and QSPR Model Interpretation Using Partial Least Squares (PLS) Analysis

(2012) David T. Stanton   Current Computer-Aided Drug Design

Chromatin remodeling in Cancer: A Gateway to regulate gene Transcription

(2012) Sujit S. Nair et al.   Molecular Oncology

Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations

(2012) Brian J. O’Roak et al.   NATURE

Chidamide (CS055/HBI-8000): a new histone deacetylase inhibitor of the benzamide class with antitumor activity and the ability to enhance immune cell-mediated tumor cell cytotoxicity

(2011) Zhi-Qiang Ning et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Computational Repositioning of the Anticonvulsant Topiramate for Inflammatory Bowel Disease

(2011) J. T. Dudley et al.   Science Translational Medicine

BEDTools: a flexible suite of utilities for comparing genomic features

(2010) Aaron R. Quinlan et al.   BIOINFORMATICS

Selective inhibition of BET bromodomains

(2010) Panagis Filippakopoulos et al.   NATURE

The Application of Phenotypic High-Throughput Screening Techniques to Cardiovascular Research

(2010) Yoram Etzion et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Docking and chemoinformatic screens for new ligands and targets

(2009) Peter Kolb et al.   CURRENT OPINION IN BIOTECHNOLOGY

Current Mathematical Methods Used in QSAR/QSPR Studies

(2009) Peixun Liu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Predicting new molecular targets for known drugs

(2009) Michael J. Keiser et al.   NATURE

KEGG for representation and analysis of molecular networks involving diseases and drugs

(2009) Minoru Kanehisa et al.   NUCLEIC ACIDS RESEARCH

ChIP-Seq of transcription factors predicts absolute and differential gene expression in embryonic stem cells

(2009) Z. Ouyang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein-ligand interaction prediction: an improved chemogenomics approach

(2008) Laurent Jacob et al.   BIOINFORMATICS