Journal
TRENDS IN CARDIOVASCULAR MEDICINE
Volume 19, Issue 6, Pages 207-212Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcm.2009.12.006
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Funding
- NHLBI NIH HHS [R01 HL091913-01A1, P01 HL057278-100006, R01 HL076670-05] Funding Source: Medline
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In traditional pure protein high-throughput drug screens, also called in vitro screens, individual compounds from a small molecule collection are tested to determine whether they inhibit the enzymatic activity or binding properties of a purified target protein. In contrast, phenotypic high-throughput drug screens, also called chemical genetic or in vivo screens, investigate the ability of individual compounds from a collection to inhibit a biological process or disease model in live cells or intact organisms. In this review, the role of phenotypic screening techniques to identify novel therapeutic agents for the treatment of cardiovascular disease will be discussed. (Trends Cardiovasc Med 2009;19:207-212) (C) 2009, Elsevier Inc.
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