Systematic evaluation of connectivity map for disease indications

Drug-repurposing identified the combination of Trolox C and Cytisine for the treatment of type 2 diabetes

(2014) Ling Jin et al.   Journal of Translational Medicine

Good practice guidelines for biomarker discovery from array data: a case study for breast cancer prognosis

(2013) Jie Cheng et al.   BMC Systems Biology

DvD: An R/Cytoscape pipeline for drug repurposing using public repositories of gene expression data

(2012) Clare Pacini et al.   BIOINFORMATICS

Applications of Connectivity Map in drug discovery and development

(2012) Xiaoyan A. Qu et al.   DRUG DISCOVERY TODAY

Exploiting drug-disease relationships for computational drug repositioning

(2011) J. T. Dudley et al.   BRIEFINGS IN BIOINFORMATICS

mRNA Expression Signatures of Human Skeletal Muscle Atrophy Identify a Natural Compound that Increases Muscle Mass

(2011) Steven D. Kunkel et al.   Cell Metabolism

PREDICT: a method for inferring novel drug indications with application to personalized medicine

(2011) A. Gottlieb et al.   Molecular Systems Biology

Gene Expression Signature Analysis Identifies Vorinostat as a Candidate Therapy for Gastric Cancer

(2011) Sofie Claerhout et al.   PLoS One

Computational Repositioning of the Anticonvulsant Topiramate for Inflammatory Bowel Disease

(2011) J. T. Dudley et al.   Science Translational Medicine

Discovery and Preclinical Validation of Drug Indications Using Compendia of Public Gene Expression Data

(2011) M. Sirota et al.   Science Translational Medicine

Evaluation of Phenoxybenzamine in the CFA Model of Pain following Gene Expression Studies and Connectivity Mapping

(2010) Meiping Chang et al.   Molecular Pain

Discovery of drug mode of action and drug repositioning from transcriptional responses

(2010) F. Iorio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drug-Induced Regulation of Target Expression

(2010) Murat Iskar et al.   PLoS Computational Biology

Network-Based Elucidation of Human Disease Similarities Reveals Common Functional Modules Enriched for Pluripotent Drug Targets

(2010) Silpa Suthram et al.   PLoS Computational Biology

Identification of novel hair-growth inducers by means of connectivity mapping

(2009) Yumiko Ishimatsu-Tsuji et al.   FASEB JOURNAL

Human Disease-Drug Network Based on Genomic Expression Profiles

(2009) Guanghui Hu et al.   PLoS One

A simple and robust method for connecting small-molecule drugs using gene-expression signatures

(2008) Shu-Dong Zhang et al.   BMC BIOINFORMATICS