Metabolic engineering of microbes for monoterpenoid production

A Burkholderia thailandensis DedA Family Membrane Protein Is Required for Proton Motive Force Dependent Lipid A Modification

(2021) Pradip R. Panta et al.   Frontiers in Microbiology

Efficient production of oxidized terpenoids via engineering fusion proteins of terpene synthase and cytochrome P450

(2021) Xi Wang et al.   METABOLIC ENGINEERING

Improving the production of NAD+ via multi-strategy metabolic engineering in Escherichia coli

(2021) Linyan Yang et al.   METABOLIC ENGINEERING

Studies on Upgradation of Waste Fish Oil to Lipid-Rich Yeast Biomass in Yarrowia lipolytica Batch Cultures

(2021) Agata Urszula Fabiszewska et al.   Foods

Dynamic Control of Gene Expression with Riboregulated Switchable Feedback Promoters

(2021) Cameron J. Glasscock et al.   ACS Synthetic Biology

Simultaneous Improvement of Limonene Production and Tolerance in Yarrowia lipolytica through Tolerance Engineering and Evolutionary Engineering

(2021) Jian Li et al.   ACS Synthetic Biology

Chemical Synthesis of Multifunctional Air Pollutants: Terpene-Derived Nitrooxy Organosulfates

(2021) Yuchen Wang et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Combining Metabolic and Monoterpene Synthase Engineering for de Novo Production of Monoterpene Alcohols in Escherichia coli

(2021) Dengwei Lei et al.   ACS Synthetic Biology

Combinatorial engineering of Saccharomyces cerevisiae for improving limonene production

(2021) Xue Zhang et al.   BIOCHEMICAL ENGINEERING JOURNAL

Trehalose Protects the Probiotic Yeast Saccharomyces boulardii against Oxidative Stress-Induced Cell Death

(2020) Ji Eun Moon et al.   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

Metabolic engineering of E. coli for improving mevalonate production to promote NADPH regeneration and enhance acetyl‐CoA supply

(2020) Daichi Satowa et al.   BIOTECHNOLOGY AND BIOENGINEERING

A Gram-Scale Limonene Production Process with Engineered Escherichia coli

(2020) Jascha Rolf et al.   MOLECULES

Accumulation of high-value bioproducts in planta can improve the economics of advanced biofuels

(2020) Minliang Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhancing β-Carotene Production in Escherichia coli by Perturbing Central Carbon Metabolism and Improving the NADPH Supply

(2020) Yuanqing Wu et al.   Frontiers in Bioengineering and Biotechnology

Overexpression of the Key Enzymes in the Methylerythritol 4-phosphate Pathway in Corynebacterium glutamicum for Improving Farnesyl Diphosphate-Derived Terpene Production

(2020) Hyeonbae Lim et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Production of the Fragrance Geraniol in Peroxisomes of a Product-Tolerant Baker’s Yeast

(2020) Jennifer Gerke et al.   Frontiers in Bioengineering and Biotechnology

Yarrowia lipolytica Strains Engineered for the Production of Terpenoids

(2020) Jonathan Asmund Arnesen et al.   Frontiers in Bioengineering and Biotechnology

Biosynthesis of α-Pinene by Genetically Engineered Yarrowia lipolytica from Low-Cost Renewable Feedstocks

(2020) Liu-Jing Wei et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Improve the production of d-limonene by regulating the mevalonate pathway of Saccharomyces cerevisiae during alcoholic beverage fermentation

(2020) Zhihui Hu et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Transforming yeast peroxisomes into microfactories for the efficient production of high-value isoprenoids

(2020) Simon Dusséaux et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Artificial Pathway for Isoprenoid Biosynthesis Decoupled from Native Hemiterpene Metabolism

(2019) Sean Lund et al.   ACS Synthetic Biology

Engineering Robust Production Microbes for Large-Scale Cultivation

(2019) Maren Wehrs et al.   TRENDS IN MICROBIOLOGY

Primary and Secondary Metabolic Effects of a Key Gene Deletion (ΔYPL062W) in Metabolically Engineered Terpenoid-Producing Saccharomyces cerevisiae

(2019) Yan Chen et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Biosynthesis of nerol from glucose in the metabolic engineered Escherichia coli

(2019) Zhen Zong et al.   BIORESOURCE TECHNOLOGY

Orthogonal Engineering of Biosynthetic Pathway for Efficient Production of Limonene in Saccharomyces cerevisiae

(2019) Si Cheng et al.   ACS Synthetic Biology

Elevating Limonene Production in Oleaginous Yeast Yarrowia lipolytica via Genetic Engineering of Limonene Biosynthesis Pathway and Optimization of Medium Composition

(2019) Bo-Qian Cheng et al.   BIOTECHNOLOGY AND BIOPROCESS ENGINEERING

Systematic Optimization of Limonene Production in Engineered Escherichia coli

(2019) Jihua Wu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

The mitochondrial citrate carrier in Yarrowia lipolytica: Its identification, characterization and functional significance for the production of citric acid

(2019) Evgeniya Y. Yuzbasheva et al.   METABOLIC ENGINEERING

The isoprenoid alcohol pathway, a synthetic route for isoprenoid biosynthesis

(2019) James M. Clomburg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Optimization of limonene biotransformation for the production of bulk amounts of α-terpineol

(2019) Gustavo Molina et al.   BIORESOURCE TECHNOLOGY

Engineered mitochondrial production of monoterpenes in Saccharomyces cerevisiae

(2019) Danielle A. Yee et al.   METABOLIC ENGINEERING

Subcellular engineering of lipase dependent pathways directed towards lipid related organelles for highly effectively compartmentalized biosynthesis of triacylglycerol derived products in Yarrowia lipolytica

(2019) Kaixin Yang et al.   METABOLIC ENGINEERING

Engineering the oleaginous yeast Yarrowia lipolytica to produce limonene from waste cooking oil

(2019) Yaru Pang et al.   Biotechnology for Biofuels

Investigation of the methylerythritol 4-phosphate pathway for microbial terpenoid production through metabolic control analysis

(2019) Daniel Christoph Volke et al.   Microbial Cell Factories

Orthogonal monoterpenoid biosynthesis in yeast constructed on an isomeric substrate

(2019) Codruta Ignea et al.   Nature Communications

In‐depth characterization of genome‐scale network reconstructions for the in vitro synthesis in cell‐free systems

(2019) Lisa Katharina Schuh et al.   BIOTECHNOLOGY AND BIOENGINEERING

ESCRT machinery mediates selective microautophagy of endoplasmic reticulum in yeast

(2019) Jasmin A Schäfer et al.   EMBO JOURNAL

High-level production of linalool by engineered Saccharomyces cerevisiae harboring dual mevalonate pathways in mitochondria and cytoplasm

(2019) Yaoyao Zhang et al.   ENZYME AND MICROBIAL TECHNOLOGY

Tailoring the Saccharomyces cerevisiae endoplasmic reticulum for functional assembly of terpene synthesis pathway

(2019) Jae-Eung Kim et al.   METABOLIC ENGINEERING

Squalene lipotoxicity in a lipid droplet‐less yeast mutant is linked to plasma membrane dysfunction

(2019) Zsófia Csáky et al.   YEAST

Engineered protein degradation of farnesyl pyrophosphate synthase is an effective regulatory mechanism to increase monoterpene production in Saccharomyces cerevisiae

(2018) Bingyin Peng et al.   METABOLIC ENGINEERING

Synthetic addiction extends the productive life time of engineeredEscherichia colipopulations

(2018) Peter Rugbjerg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhanced Triacylglycerol Production With Genetically Modified Trichosporon oleaginosus

(2018) Kari Koivuranta et al.   Frontiers in Microbiology

An enzyme-coupled assay enables rapid protein engineering for geraniol production in yeast

(2018) Jyun-Liang Lin et al.   BIOCHEMICAL ENGINEERING JOURNAL

A lavender ABC transporter confers resistance to monoterpene toxicity in yeast

(2018) Zerihun A. Demissie et al.   PLANTA

Engineering cyanobacteria for production of terpenoids

(2018) Po-Cheng Lin et al.   PLANTA

Two-step pathway for isoprenoid synthesis

(2018) Alkiviadis Orfefs Chatzivasileiou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipid engineering combined with systematic metabolic engineering of Saccharomyces cerevisiae for high-yield production of lycopene

(2018) Tian Ma et al.   METABOLIC ENGINEERING

Regeneration of NADPH Coupled with HMG-CoA Reductase Activity Increases Squalene Synthesis in Saccharomyces cerevisiae

(2017) Kalaivani Paramasivan et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Enhanced performance of the methylerythritol phosphate pathway by manipulation of redox reactions relevant to IspC, IspG, and IspH

(2017) Jia Zhou et al.   JOURNAL OF BIOTECHNOLOGY

Effects of acetoacetyl-CoA synthase expression on production of farnesene in Saccharomyces cerevisiae

(2017) Stefan Tippmann et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Manipulation of GES and ERG20 for geraniol overproduction in Saccharomyces cerevisiae

(2017) Guo-Zhen Jiang et al.   METABOLIC ENGINEERING

Iterative integration of multiple-copy pathway genes in Yarrowia lipolytica for heterologous β-carotene production

(2017) Shuliang Gao et al.   METABOLIC ENGINEERING

Autonomous control of metabolic state by a quorum sensing (QS)-mediated regulator for bisabolene production in engineered E. coli

(2017) Eun-Mi Kim et al.   METABOLIC ENGINEERING

Mutants of Yarrowia lipolytica NCIM 3589 grown on waste cooking oil as a biofactory for biodiesel production

(2017) Gouri Katre et al.   Microbial Cell Factories

Dynamic control of ERG20 expression combined with minimized endogenous downstream metabolism contributes to the improvement of geraniol production in Saccharomyces cerevisiae

(2017) Jianzhi Zhao et al.   Microbial Cell Factories

A synthetic biochemistry platform for cell free production of monoterpenes from glucose

(2017) Tyler P. Korman et al.   Nature Communications

Photosynthetic conversion of CO2 to farnesyl diphosphate-derived phytochemicals (amorpha-4,11-diene and squalene) by engineered cyanobacteria

(2016) Sun Young Choi et al.   Biotechnology for Biofuels

Metabolic engineering of oleaginous yeast Yarrowia lipolytica for limonene overproduction

(2016) Xuan Cao et al.   Biotechnology for Biofuels

Engineering Escherichia coli for high-yield geraniol production with biotransformation of geranyl acetate to geraniol under fed-batch culture

(2016) Wei Liu et al.   Biotechnology for Biofuels

Engineering cytosolic acetyl-coenzyme A supply in Saccharomyces cerevisiae : Pathway stoichiometry, free-energy conservation and redox-cofactor balancing

(2016) Harmen M. van Rossum et al.   METABOLIC ENGINEERING

Engineering cofactor and transport mechanisms in Saccharomyces cerevisiae for enhanced acetyl-CoA and polyketide biosynthesis

(2016) Javier Cardenas et al.   METABOLIC ENGINEERING

Synergy between methylerythritol phosphate pathway and mevalonate pathway for isoprene production in Escherichia coli

(2016) Chen Yang et al.   METABOLIC ENGINEERING

Genome-wide Escherichia coli stress response and improved tolerance towards industrially relevant chemicals

(2016) Martin Holm Rau et al.   Microbial Cell Factories

ATP citrate lyase mediated cytosolic acetyl-CoA biosynthesis increases mevalonate production in Saccharomyces cerevisiae

(2016) Sarah Rodriguez et al.   Microbial Cell Factories

Distinct transcriptional regulation of the two Escherichia coli transhydrogenases PntAB and UdhA

(2016) Bart R. B. Haverkorn van Rijsewijk et al.   MICROBIOLOGY-SGM

Enhanced limonene production in cyanobacteria reveals photosynthesis limitations

(2016) Xin Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineering an NADPH/NADP+ Redox Biosensor in Yeast

(2016) Jie Zhang et al.   ACS Synthetic Biology

Acute Limonene Toxicity in Escherichia coli Is Caused by Limonene Hydroperoxide and Alleviated by a Point Mutation in Alkyl Hydroperoxidase AhpC

(2015) Victor Chubukov et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Evolutionary Engineering Improves Tolerance for Replacement Jet Fuels in Saccharomyces cerevisiae

(2015) Timothy C. R. Brennan et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Compartmentalizing metabolic pathway in Candida glabrata for acetoin production

(2015) Shubo Li et al.   METABOLIC ENGINEERING

Principal component analysis of proteomics (PCAP) as a tool to direct metabolic engineering

(2015) Jorge Alonso-Gutierrez et al.   METABOLIC ENGINEERING

Rational design of a synthetic Entner–Doudoroff pathway for improved and controllable NADPH regeneration

(2015) Chiam Yu Ng et al.   METABOLIC ENGINEERING

De novo production of the plant-derived alkaloid strictosidine in yeast

(2015) Stephanie Brown et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineering the productivity of recombinantEscherichia colifor limonene formation from glycerol in minimal media

(2014) Christian Willrodt et al.   Biotechnology Journal

Biosynthesis of pinene from glucose using metabolically-engineered Corynebacterium glutamicum

(2014) Min-Kyoung Kang et al.   BIOTECHNOLOGY LETTERS

Limonene: a versatile chemical of the bioeconomy

(2014) Rosaria Ciriminna et al.   CHEMICAL COMMUNICATIONS

Engineering of cyanobacteria for the photosynthetic production of limonene from CO2

(2014) Hiroshi Kiyota et al.   JOURNAL OF BIOTECHNOLOGY

De novo production of the monoterpenoid geranic acid by metabolically engineered Pseudomonas putida

(2014) Jia Mi et al.   Microbial Cell Factories

Acetylation dynamics and stoichiometry in Saccharomyces cerevisiae

(2014) B. T. Weinert et al.   Molecular Systems Biology

Differential Mechanism of Escherichia coli Inactivation by (+)-Limonene as a Function of Cell Physiological State and Drug's Concentration

(2014) Beatriz Chueca et al.   PLoS One

Microbial monoterpene transformations—a review

(2014) Robert Marmulla et al.   Frontiers in Microbiology

Physiological and Transcriptional Responses of Saccharomyces cerevisiae tod-Limonene Show Changes to the Cell Wall but Not to the Plasma Membrane

(2013) Timothy C. R. Brennan et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Response of Saccharomyces cerevisiae to D-limonene-induced oxidative stress

(2013) Jidong Liu et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Lycopene production in recombinant strains of Escherichia coli is improved by knockout of the central carbon metabolism gene coding for glucose-6-phosphate dehydrogenase

(2013) Yan Zhou et al.   BIOTECHNOLOGY LETTERS

RecA-mediated SOS response provides a geraniol tolerance in Escherichia coli

(2013) Asad Ali Shah et al.   JOURNAL OF BIOTECHNOLOGY

Overproduction of geraniol by enhanced precursor supply in Saccharomyces cerevisiae

(2013) Jidong Liu et al.   JOURNAL OF BIOTECHNOLOGY

Engineering Escherichia coli for selective geraniol production with minimized endogenous dehydrogenation

(2013) Jia Zhou et al.   JOURNAL OF BIOTECHNOLOGY

Metabolic engineering of Escherichia coli for limonene and perillyl alcohol production

(2013) Jorge Alonso-Gutierrez et al.   METABOLIC ENGINEERING

Engineering central metabolic modules of Escherichia coli for improving β-carotene production

(2013) Jing Zhao et al.   METABOLIC ENGINEERING

2,2-Diphenyl-1-picrylhydrazyl as a screening tool for recombinant monoterpene biosynthesis

(2013) James BYH Behrendorff et al.   Microbial Cell Factories

Engineering Monoterpene Production in Yeast Using a Synthetic Dominant Negative Geranyl Diphosphate Synthase

(2013) Codruta Ignea et al.   ACS Synthetic Biology

Novel physiological roles for glutathione in sequestering acetaldehyde to confer acetaldehyde tolerance in Saccharomyces cerevisiae

(2012) Yoshimi Matsufuji et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Key cytomembrane ABC transporters of Saccharomyces cerevisiae fail to improve the tolerance to d-limonene

(2012) Feifei Hu et al.   BIOTECHNOLOGY LETTERS

Genetic analysis of geraniol metabolism during fermentation

(2012) Damien Steyer et al.   FOOD MICROBIOLOGY

Enhancement of geraniol resistance of Escherichia coli by MarA overexpression

(2012) Asad Ali Shah et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Establishing a platform cell factory through engineering of yeast acetyl-CoA metabolism

(2012) Yun Chen et al.   METABOLIC ENGINEERING

A specialized ABC efflux transporter GcABC-G1 confers monoterpene resistance toGrosmannia clavigera, a bark beetle-associated fungal pathogen of pine trees

(2012) Ye Wang et al.   NEW PHYTOLOGIST

An overview of lipid metabolism in yeasts and its impact on biotechnological processes

(2011) Athanasios Beopoulos et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

The feasibility of growing cells of Saccharomyces cerevisiae for citronellol production in a continuous-closed-gas-loop bioreactor (CCGLB)

(2011) Aimi Aishah Arifin et al.   BIORESOURCE TECHNOLOGY

Improving yeast strains using recyclable integration cassettes, for the production of plant terpenoids

(2011) Codruta Ignea et al.   Microbial Cell Factories

Enzymes of the mevalonate pathway of isoprenoid biosynthesis

(2010) Henry M. Miziorko   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Metabolic engineering of Escherichia coli for the production of cadaverine: A five carbon diamine

(2010) Zhi-Gang Qian et al.   BIOTECHNOLOGY AND BIOENGINEERING

Adaptive response to oxidative stress: Bacteria, fungi, plants and animals

(2010) Volodymyr I. Lushchak   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY

Revisiting the IspH Catalytic System in the Deoxyxylulose Phosphate Pathway: Achieving High Activity

(2009) Youli Xiao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Monoterpenes in the glandular trichomes of tomato are synthesized from a neryl diphosphate precursor rather than geranyl diphosphate

(2009) A. L. Schilmiller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Azadirachtin, a scientific gold mine

(2008) E. David Morgan   BIOORGANIC & MEDICINAL CHEMISTRY

Terpenoids: Opportunities for Biosynthesis of Natural Product Drugs Using Engineered Microorganisms

(2008) Parayil Kumaran Ajikumar et al.   MOLECULAR PHARMACEUTICS

NAD+/NADH and NADP+/NADPH in Cellular Functions and Cell Death: Regulation and Biological Consequences

(2007) Weihai Ying   ANTIOXIDANTS & REDOX SIGNALING