Review
Multidisciplinary Sciences
Bai-Ru Cheng, Jia-Qi Chen, Xiao-Wen Zhang, Qin-Yang Gao, Wei-Hong Li, Li-Jiao Yan, Yu-Qiao Zhang, Chang-Jiang Wu, Jing-Li Xing, Jian-Ping Liu
Summary: Celecoxib is relatively safe in patients with rheumatoid arthritis and osteoarthritis, showing benefits in terms of all-cause mortality and cardiovascular mortality compared to non-selective non-steroidal anti-inflammatory drugs. However, there is no significant difference in the risk of other cardiovascular events compared to non-selective NSAIDs or placebo.
Article
Immunology
Ling Ma, Liguo Zhang, Hanbing Wang, Changlin Jiang
Summary: Preoperative analgesia using NSAIDs is more effective and equally tolerable compared to postoperative analgesia in patients undergoing AKS, leading to decreased pain, rescue drug consumption, and increased overall satisfaction.
INFLAMMOPHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Foong Way David Tai, Mark E. McAlindon
Summary: NSAIDs are commonly used for treatment, but can cause a variety of gastrointestinal symptoms, which can be reduced by limiting their use or co-administering with proton pump inhibitors (PPIs) to reduce associated complications.
Article
Biochemistry & Molecular Biology
Agnieszka Siemieniuk, Michal Ludynia, Malgorzata Rudnicka
Summary: The research found that tomatoes are more sensitive to NSAIDs, experiencing growth inhibition and other effects, while corn is less affected by these drugs. Plants showed activation of defense mechanisms in response to the oxidative stress triggered by NSAIDs treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Juliana de Lima Goncalves, Ana Caroline Alves Duarte, Luciano Aparecido Almeida-Junior, Fabricio Kitazono de Carvalho, Alexandra Mussolino de Queiroz, Maya Fernanda Manfrin Arnez, Lucia Helena Faccioli, Francisco Wanderley Garcia Paula-Silva
Summary: The aim of this study was to explore the effects of nonsteroidal anti-inflammatory drugs on biomineralization of enamel. The results showed that treatment with indomethacin and celecoxib reduced the Ca and P content, microhardness and mineral density in enamel, and affected the synthesis and activity of related proteins and enzymes.
SCIENTIFIC REPORTS
(2022)
Article
Environmental Sciences
Sorina Motoc, Florica Manea, Anamaria Baciu, Sergiu Vasilie, Aniela Pop
Summary: The development of simultaneous detection methods for anti-inflammatory drugs in water is challenging but important for water quality control. In this study, fullerene-carbon nanofiber (FULL/CNF) and graphene-carbon nanotubes (GR/CNT) were used for the first time as sensing elements for simultaneous determination of diclofenac, naproxen, and ibuprofen. The FULL/CNE electrode showed good performance with DPV-based detection, while the GR/CNT electrode achieved low limits of detection with MPA-based methodology. Both electrodes demonstrated good reproducibility, stability, and the ability to measure the drugs simultaneously in water samples.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Cell Biology
Roua Chaabani, Mohamed Bejaoui, Ikram Ben Jeddou, Mohamed Amine Zaouali, Zohra Haouas, Sameh Belgacem, Carmen Peralta, Hassen Ben Abdennebi
Summary: This study found that diclofenac has beneficial effects on hepatic ischemia/reperfusion injury (IRI) by reducing oxidative stress, inflammation, and apoptosis. It activates the eNOS pathway, which contributes to its protective effects.
Review
Orthopedics
Nicola Veronese, Fiona Ecarnot, Sara Cheleschi, Antonella Fioravanti, Stefania Maggi
Summary: This scoping review investigates the potential benefits and synergistic effect of a combination of glucosamine sulfate (GS) and non-steroidal anti-inflammatory drugs (NSAIDs) in patients with knee osteoarthritis (OA). The review includes 5 studies and finds that the combination of GS plus NSAID yields significantly greater clinical benefits compared to either treatment alone, particularly in terms of pain reduction, function improvement, and regulation of joint damage.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Chemistry, Multidisciplinary
Asma Sardar, Obaid-ur-Rahman Abid, Saima Daud, Basit Ali Shah, Wardah Shahid, Muhammad Ashraf, Mahvish Fatima, Safa Ezzine, Abdul Wadood, Azam Shareef, Hanan A. Al-Ghulikah, Siham A. Alissa
Summary: Inflammation is the immune system's response to tissue dysfunction or homeostatic imbalance, involving the COX and LOX pathways. This study synthesized a series of diclofenac acid and naproxen-bearing hydrazones and evaluated their inhibitory potential against the 15-LOX enzyme. The compounds showed varying degrees of inhibitory potential, with compounds 7c and 7f being the most potent. Additionally, these compounds demonstrated low cytotoxicity in cells.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Mohammad Abdel-Halim, Sara Sigler, Nora A. S. Racheed, Amr Hefnawy, Reem K. Fathalla, Mennatallah A. Hammam, Ahmed Maher, Yulia Maxuitenko, Adam B. Keeton, Rolf W. Hartmann, Matthias Engel, Gary A. Piazza, Ashraf H. Abadi
Summary: A ligand-based approach was used to develop novel PDE5 inhibitors by systematically modifying a trisubstituted pyrazoline scaffold derived from the COX2 inhibitor celecoxib. Novel pyrazolines, such as compound d12, were identified with potent PDE5 inhibitory activity and high selectivity against other PDE isozymes, showing no discernible toxicity and achieving plasma levels >1000-fold higher than IC50 values. These results suggest a novel strategy to inhibit PDE5 with unprecedented potency and isozyme selectivity.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Ahmed S. Abdelkhalek, Hend Kothayer, Samar Rezq, Khaled Y. Orabi, Damian G. Romero, Osama I. El-Sabbagh
Summary: A new series of thieno[2,3-d]pyrimidine derivatives were synthesized as multitarget-directed ligands (MTDLs) with anti-inflammatory properties against both 15-LOX and COX-2 enzymes. Compound 6o showed the most potent inhibitory effect on 15-LOX and compounds 6h, 6g, 11, and 4 exhibited good activities. These compounds have the potential to be promising multi-targeted anti-inflammatory candidates.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Lavanya Mude, Srikanth Jupudi, Akey Krishna Swaroop, Vyshnavi Tallapaneni, Veera Venkata Satyanarayana Reddy Karri
Summary: This study aims to repurpose celecoxib against MMP-2, MMP-8, and MMP-9 using in silico approaches. The results showed that celecoxib exhibited significant binding affinity against these MMPs and formed hydrogen bonding and hydrophobic interactions with crucial substrate pocket amino acids. The analysis of secondary structures also indicated the stability of celecoxib binding conformation during simulation.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Review
Chemistry, Medicinal
Afaf A. El-Malah, Magdy M. Gineinah, Pran Kishore Deb, Ahdab N. Khayyat, Monika Bansal, Katharigatta N. Venugopala, Anfal S. Aljahdali
Summary: The introduction of selective COX-2 inhibitors (coxibs) achieved great commercial success initially but faced controversy and voluntary withdrawal due to safety concerns. However, there is now potential for repurposing coxibs in the management of various diseases. Lessons from this experience highlight the need for improved drug surveillance and regulation to avoid risks.
Article
Environmental Sciences
Katarzyna Kolecka, Magdalena Gajewska, Magda Caban
Summary: The extent of pharmaceutical pollution in the environment requires more automatic and integrated solutions. This study focused on the correlation between sales data of non-steroidal anti-inflammatory drugs (NSAIDs) and their concentration in wastewater treatment plants (WWTPs). The findings suggest that a significant amount of sold NSAIDs are improperly disposed into the sewage system, emphasizing the need for future predictions and risk assessments to consider this factor.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Oncology
R. Charles Coombes, Holly Tovey, Lucy Kilburn, Janine Mansi, Carlo Palmieri, John Bartlett, Jonathan Hicks, Andreas Makris, Abigail Evans, Sibylle Loibl, Carsten Denkert, Elisabeth Murray, Robert Grieve, Robert Coleman, Annabel Borley, Marcus Schmidt, Beate Rautenberg, Catarina Alisa Kunze, Uwe Rhein, Keyur Mehta, Kelly Mousa, Tessa Dibble, Xiao Lou Lu, Gunter von Minckwitz, Judith M. Bliss
Summary: The Randomized European Celecoxib Trial (REACT) evaluated the role of Celecoxib as an addition to conventional therapy for women with ERBB2-negative primary breast cancer. The study did not find evidence of a disease-free survival benefit for patients receiving 2 years of Celecoxib treatment compared to placebo. Longer-term treatment or higher doses of Celecoxib may need to be explored in further studies to determine potential benefits.
Article
Psychiatry
Daniel Owusu, Yue Pan, Changchun Xie, Sam Harirforoosh, Ke-Sheng Wang
JOURNAL OF PSYCHIATRIC RESEARCH
(2017)
Article
Pharmacology & Pharmacy
Aaron J. Salwan, Nicholas E. Hagemeier, Sam Harirforoosh
CLINICAL DRUG INVESTIGATION
(2018)
Article
Endocrinology & Metabolism
Hadii M. Mamudu, Pooja Subedi, Timir Paul, Ali E. Alamin, Arsham Alamian, Liang Wang, David Stewart, Antwan Jones, Sam Harirforoosh, Gerald Blackwell, Matthew Budoff
JOURNAL OF DIABETES AND ITS COMPLICATIONS
(2018)
Article
Psychiatry
Yang Chen, Chun Xu, Sam Harirforoosh, Xingguang Luo, Ke-Sheng Wang
JOURNAL OF PSYCHIATRIC RESEARCH
(2018)
Article
Pharmacology & Pharmacy
Derek E. Murrell, David B. Cluck, Jonathan P. Moorman, Stacy D. Brown, Ke-Sheng Wang, Michelle M. Duffourc, Sam Harirforoosh
CLINICAL DRUG INVESTIGATION
(2019)
Review
Pharmacology & Pharmacy
James C. Thigpen, Brian L. Odle, Sam Harirforoosh
EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS
(2019)
Article
Biotechnology & Applied Microbiology
Ogbebor Enaholo Omoike, Timir K. Paul, Stanley L. Ridner, Manul Awasthi, Sam Harirforoosh, Hadii M. Mamudu
Editorial Material
Education, Scientific Disciplines
Brooks B. Pond, Stacy D. Brown, David W. Stewart, David S. Roane, Sam Harirforoosh
AMERICAN JOURNAL OF PHARMACEUTICAL EDUCATION
(2019)
Letter
Education, Scientific Disciplines
David S. Roane, Sam Harirforoosh
AMERICAN JOURNAL OF PHARMACEUTICAL EDUCATION
(2019)
Review
Pharmacology & Pharmacy
Derek Murrell, John B. Bossaer, Ronald Carico, Sam Harirforoosh, David Cluck
INTERNATIONAL JOURNAL OF PHARMACY PRACTICE
(2017)
Article
Pharmacology & Pharmacy
S. Harirforoosh, K. O. West, D. E. Murrell, J. W. Denham, P. C. Panus, G. A. Hanley
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2016)
Article
Pharmacology & Pharmacy
S. Harirforoosh, K. O. West, D. E. Murrell, J. W. Denham, P. C. Panus, G. A. Hanley
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2016)
Article
Pharmacology & Pharmacy
D. E. Murrell, Y. Rahmasari, J. W. Denham, P. C. Panus, S. Harirforoosh
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2015)
Article
Pathology
Derek E. Murrell, James W. Denham, Sam Harirforoosh
JOURNAL OF TOXICOLOGIC PATHOLOGY
(2015)