Article
Biochemistry & Molecular Biology
Vesna Manasieva, Shori Thakur, Lisa A. Lione, Jessal Patel, Anwar Baydoun, John Skamarauskas
Summary: The study demonstrates the relationship between SSAO and LOX in VSMCs, showing that increased SSAO activity and decreased LOX activity are associated with pathological changes in the vascular wall. Silencing the LOX gene leads to a reduction in SSAO activity, protein expression, and mRNA levels in VSMCs. These findings suggest that LOX acts as a regulator of SSAO activity and expression in early passage rat aortic VSMCs.
Article
Transplantation
Chenyang Qi, Faten Alsomali, Jinyong Zhong, Raymond C. Harris, Valentina Kon, Haichun Yang, Agnes B. Fogo
Summary: DAAM2 expression is upregulated in human and mouse glomeruli, possibly associated with glomerular hypertrophy. Knockdown of DAAM2 enhances adhesion, slows migration, and influences cell signaling pathways.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Article
Medicine, General & Internal
Sunil Bhandari, Samir Mehta, Arif Khwaja, John G. F. Cleland, Natalie Ives, Elizabeth Brettell, Marie Chadburn, Paul Cockwell
Summary: Discontinuation of RAS inhibitors was not associated with a significant difference in the long-term rate of decrease in eGFR among patients with advanced and progressive chronic kidney disease, as well as in other outcomes.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Endocrinology & Metabolism
Mark E. Molitch, Mark Tripputi, Andrew S. Levey, Jill P. Crandall, Dana Dabelea, William H. Herman, William C. Knowler, Trevor J. Orchard, Emily B. Schroeder, Preethi Srikanthan, Marinella Temprosa, Neil H. White, David M. Nathan
Summary: This study analyzed the incidence of kidney disease in the Diabetes Prevention Program Outcomes Study (DPPOS) based on the originally randomized treatment groups. The results showed that the risk of developing kidney disease was increased in participants who developed diabetes, but it did not differ based on the treatment groups.
JOURNAL OF DIABETES AND ITS COMPLICATIONS
(2023)
Review
Urology & Nephrology
Pooja Amarapurkar, Levard Roberts, Jose Navarrete, Fuad El Rassi
Summary: Sickle cell disease can cause various kidney manifestations, such as impaired urine concentration, potassium and hydrogen ion handling, albuminuria, acute kidney injury, and chronic kidney disease. The mechanisms of kidney damage include glomerular hyperfiltration, tubular hyperfunctioning, endothelial damage from repeated sickling and vaso-occlusive episodes, and iron-induced proinflammatory changes. Albuminuria is a common clinical feature of kidney disease in sickle cell patients and tends to worsen with age.
ADVANCES IN CHRONIC KIDNEY DISEASE
(2022)
Review
Cell Biology
Samuel N. Heyman, Itamar Raz, Jamie P. Dwyer, Roni Weinberg Sibony, Julia B. Lewis, Zaid Abassi
Summary: Albuminuria is a hallmark of diabetic nephropathy and its development is influenced by various factors. Controlling glomerular albumin leak is crucial for preventing progression of the disease. Early interventions and treatments should be initiated before the onset of microalbuminuria, and the inhibition of the renin-angiotensin axis or sodium-glucose co-transport can be beneficial.
Article
Urology & Nephrology
Mitsunobu Kubota, Shizuka Matsuda, Mimu Matsuda, Kazuki Yamamoto, Yoko Yoshii
Summary: The study found that in diabetic patients, serum zinc concentration decreased with age and deteriorating renal function. Consideration of zinc deficiency is necessary in patients with overt albuminuria.
Article
Endocrinology & Metabolism
Federica Barutta, Stefania Bellini, Simonetta Guarrera, Giuseppe Matullo, Casper Schalkwijk, Coen D. Stehouwer, Nish Chaturvedi, Sabita S. Soedamah-Muthu, Marilena Durazzo, Gabriella Gruden
Summary: This study found an inverse association between miR-145-5p levels and albuminuria in patients with type 1 diabetes, and this relationship was mediated by systemic hypertension.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2022)
Article
Hematology
Baba Psalm Duniya Inusa, Ilaria Liguoro, Bamidele Tayo, Caroline Booth, Charles Turner, Neil R. Dalton
Summary: The study compared different equations for estimating glomerular filtration rate (eGFR) in children with sickle cell disease (SCD) and found that eGFR calculation based on height and MSMS traceable creatinine is more reliable than using traditional methods like the Schwartz formula with jaffe/enzymatic methods.
BLOOD CELLS MOLECULES AND DISEASES
(2021)
Article
Endocrinology & Metabolism
Ruoyu Pang, Donghai Gu
Summary: The study demonstrated that Triptolide significantly alleviated renal injury in diabetic rats, potentially by inhibiting the TGF-beta 1/Smads signaling pathway.
ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
(2021)
Article
Urology & Nephrology
Kishore Kondapi, N. Lakshmana Kumar, Swathi Moorthy, Santhi Silambanan
Summary: The study found that urinary nephrin is a better indicator of podocyte injury in patients with diabetic nephropathy compared to albuminuria, with high sensitivity and specificity. This suggests that nephrin may be a sensitive marker of early kidney dysfunction in diabetic patients.
INDIAN JOURNAL OF NEPHROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Falguni Das, Nandini Ghosh-Choudhury, Soumya Maity, Balakuntalam S. Kasinath, Goutam Ghosh Choudhury
Summary: This study demonstrates that DJ-1 regulates the expression of collagen I (alpha 2) induced by TGF beta through an mTOR- and PKC beta II-dependent mechanism, and identifies Hif1 alpha as an important transcription factor in this regulation.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Review
Endocrinology & Metabolism
Tetsuya Babazono, Tatsumi Moriya
Summary: Recently in Japan, the term "diabetic kidney disease" has been used instead of "diabetic nephropathy." This change is based on observations of changes in the kidney phenotype of diabetic patients, including a decrease in albuminuria. The rationale behind this change is to create a more easily understood term for English speakers, rather than to encompass a broader population of diabetes with chronic kidney disease (CKD).
DIABETOLOGY INTERNATIONAL
(2023)
Article
Urology & Nephrology
Xiaoyi Zheng, Lauren Higdon, Alexandre Gaudet, Manav Shah, Angela Balistieri, Catherine Li, Patricia Nadai, Latha Palaniappan, Xiaoping Yang, Briana Santo, Brandon Ginley, Xiaoxin X. Wang, Komuraiah Myakala, Pratima Nallagatla, Moshe Levi, Pinaki Sarder, Avi Rosenberg, Jonathan S. Maltzman, Nathalie de Freitas Caires, Vivek Bhalla
Summary: This study demonstrates the important protective role of Esm-1 in diabetic kidney disease, inhibiting the development of the disease by reducing albuminuria and podocyte injury, possibly through interferon signaling pathways.
Review
Food Science & Technology
Hai-Ying Chen, Jin-Yu Lei, Shu-Li Li, Li-Qiong Guo, Jun-Fang Lin, Guang-Hong Wu, Jun Lu, Zhi-Wei Ye
Summary: Edible fungi contain terpenoids, which have both edible and medicinal functions. Terpenoids possess a wide range of biological activities and show great potential in the pharmaceutical and healthcare industries. This review summarizes the diverse biological activities of terpenoids in edible fungi, with a focus on the mechanisms of anti-cancer and anti-inflammation. The review also highlights the advances in understanding the biosynthesis of terpenoids in edible fungi, particularly in the generation of sesquiterpenes, diterpenes, and triterpenes.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Cardiac & Cardiovascular Systems
Yih-Kai Chan, Nerolie Stickland, Simon Stewart
Summary: This study extends the follow-up of a heart failure prevention study and shows that the initial positive effects of cardiac recovery intervention contribute to better long-term outcomes for high-risk patients. However, preventing heart failure remains challenging.
EUROPEAN JOURNAL OF CARDIOVASCULAR NURSING
(2023)
Article
Cardiac & Cardiovascular Systems
Muzeyyen Seckin, Bridget Johnston, Mark C. Petrie, Simon Stewart, Yih-Kai Chan
Summary: This study aims to examine the sex-stratified differences in heart failure (HF) subtypes based on left ventricular ejection fraction, as well as the characteristics and correlates of self-reported changes in HF symptoms. The research found significant heterogeneity in symptomatic characteristics and subsequent symptom trajectory according to sex and HF subtype among hospitalized patients with HF.
EUROPEAN JOURNAL OF CARDIOVASCULAR NURSING
(2023)
Article
Materials Science, Multidisciplinary
R. A. Sharath, F. Fang, J. Futter, W. J. Trompetter, G. Singh, A. Vinu, J. Kennedy
Summary: This study reports a controlled one-step thermal approach for creating nitrogen defects and modifying the overall structure of g-C3N4 without adding any external reducing/oxidizing agent. The defect-modified g-C3N4 showed increased surface area and bandgap compared to raw g-C3N4.
EMERGENT MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Pengfei Yuan, Litong Liu, Adila Aipire, Yanan Zhao, Shanshan Cai, Linjia Wu, Xiaofei Yang, Alimu Aimaier, Jun Lu, Jinyao Li
Summary: It has been found that the combination of gold nanoparticles and Pleurotus ferulae polysaccharide (PFPS) can enhance the immunostimulatory activity of PFPS in the maturation and function of dendritic cells (DCs), as well as improve DC migration and murine immunity, especially in type 1 T-helper cell responses. Additionally, PFPS-Au NPs have a longer half-life in the blood and increased distribution in the spleen compared to PFPS, indicating improved bioavailability in vivo. Therefore, this study paves the way for the application of PFPS-Au NPs in clinical trials.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Materials Science, Multidisciplinary
Holger Fiedler, Prasanth Gupta, Jerome Leveneur, David R. G. Mitchell, Mitchell Nancarrow, John Kennedy
Summary: We report the ion beam synthesis of buried two-dimensional AlGaN structures with enhanced piezoelectric modulus. The presence of the 2D layers was confirmed by scanning transmission electron microscopy. Alternating planar and buckled 2D III-Nitride layers with a rapid change of polarity of the buckled layer suggest weak interaction between the layers. Our results suggest the potential applications of this material in efficient energy harvesters, communication devices, power devices, and photocatalytic water splitting technologies.
APPLIED MATERIALS TODAY
(2023)
Review
Nutrition & Dietetics
Belgheis Ebrahimi, Saeid Baroutian, Jinyao Li, Baohong Zhang, Tianlei Ying, Jun Lu
Summary: This article reviews and discusses the synergistic and additive effects of marine bioactive compounds and extracts with anti-obesity, anti-inflammatory, antioxidant, and chemopreventive activities. It presents the mechanism of action, health benefits, and limitations of the studies, and provides recommendations and directions for future research.
FRONTIERS IN NUTRITION
(2023)
Review
Materials Science, Multidisciplinary
Michael Ng, Vedran Jovic, Geoffrey I. N. Waterhouse, John Kennedy
Summary: Methanol production from CO2 and H-2 has gained attention as a sustainable alternative to current production methods. Researchers are seeking photothermal catalysts to achieve optimal reaction temperatures for CO2 hydrogenation to CH3OH. Although promising catalysts have been discovered, the production rates of methanol using photothermal catalysis are still modest compared to thermochemical catalysis routes. This review summarizes recent progress in the field and explores strategies for higher CO2 conversion rates and higher CH3OH yields in the future.
EMERGENT MATERIALS
(2023)
Article
Plant Sciences
Xiuyin Chen, Mindy Y. Wang, Cecilia H. Deng, Ron A. Beatson, Kerry R. Templeton, Ross G. Atkinson, Niels J. Nieuwenhuizen
Summary: This study analyzed the volatile terpene compounds in ripe hop cones of 21 hop cultivars grown in New Zealand using gas chromatography-mass spectrometry. Different quantities of beta-myrcene, alpha-humulene, and beta-caryophyllene were found in all cultivars. Other terpenes were present in only a subset of cultivars. A total of 87 putative terpene synthase genes were identified using the published hop genome. Four terpene synthase genes were shown to produce key aroma volatiles in ripe hop cones.
Article
Medicine, Research & Experimental
Jun Lu, Xiaowu Jenifer Wu, Amira Hassouna, Kelvin Sheng Wang, Yan Li, Tao Feng, Yu Zhao, Minfeng Jin, Baohong Zhang, Tianlei Ying, Jinyao Li, Lufeng Cheng, Johnson Liu, Yue Huang
Summary: The combination of fucoxanthin, a marine carotenoid, with gemcitabine, a chemotherapeutic agent, enhances the inhibitory effect on pancreatic cancer cells without cytotoxicity to non-cancer cells. This suggests that fucoxanthin has the potential to be used as an adjunct in pancreatic cancer treatment.
BIOMEDICAL REPORTS
(2023)
Review
Multidisciplinary Sciences
Ehsan Ullah, Mirza Mansoor Baig, Hamid GholamHosseini, Jun Lu
Summary: The study aims to analyze the current use of pager devices in in-hospital communications, identify challenges and propose solutions. The use of pagers lacks standardization, content, format, urgency level, and clarity within the message. Some studies suggest that medical staff prefer in-person interactions rather than communicating through phones or pagers. The key challenges include data security, timely acknowledgement of received communication, lack of two-way communications in critical care situations, and the absence of a standard process for in-hospital communications.
Article
Respiratory System
Simon Stewart, Yih-Kai Chan, David Playford, Sarah Harris, Geoffrey A. Strange
Summary: This study addresses the lack of data on the characteristics and natural history of incident pulmonary hypertension. The findings suggest that new-onset pulmonary hypertension, even with mild elevation in estimated right ventricular systolic pressure, is associated with increased mortality risk.
Article
Public, Environmental & Occupational Health
Liangni Sally Liu, Xiaoyun Jia, Andrew Zhu, Guanyu Jason Ran, David Johnston, Richard Siegert, Yuan Gong, Nigel French, Jun Lu
Summary: This study examined Asians' risk perceptions, knowledge, and self-protection practices regarding COVID-19 in New Zealand. It found that Asians' perception of the dangerousness of COVID-19 is positively correlated with their adherence to self-protection practices.
JOURNAL OF PUBLIC HEALTH-HEIDELBERG
(2023)
Review
Oncology
Quanxiao Li, Jun Lu, Jinyao Li, Baohong Zhang, Yanling Wu, Tianlei Ying
Summary: Regulatory T cells (Tregs), which infiltrate and accumulate in the tumor microenvironment, play a role in tumor escape and progression by inducing immunosuppression. Targeting tumor-associated Tregs is effective but may also lead to autoimmune diseases due to lack of selective targets. Current therapies targeting Tregs often result in depletion of antitumor effector T-cell populations.
FRONTIERS IN ONCOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Graham Weir, William Trompetter, Jerome Leveneur, Nick Long, James Turner, John Kennedy
Summary: This paper develops a theory of low loss, unbiased minor loops in an isothermal macroscopic composite of soft magnetic particles. The theory predicts an effective macroscopic shape factor for the composite based on the average of the inverse shape factors of the particles. The low loss and composite nature of the material imply self-similarity and conjugacy of the hysteresis loops. The resulting theory depends on two non-dimensional numbers, with being a small number determining magnetic energy loss for a minor loop, while is approximately unity and determines the skewness of the minor loops. The theory is tested against different volume fractions of magnetic ferrite powder composite, supporting the concept of self-similarity in the low loss regime.
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
(2023)