Journal
NEPHROLOGY DIALYSIS TRANSPLANTATION
Volume 25, Issue 10, Pages 3204-3212Publisher
OXFORD UNIV PRESS
DOI: 10.1093/ndt/gfq217
Keywords
acute kidney failure; anti-inflammatory agents; diabetic nephropathies; inflammation; ischaemia
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Funding
- Clarian Health Partners Award
- Dialysis Clinics, Inc.
- VA
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Methods. Obese-diabetic ZS rats (F-1 hybrids of spontaneously hypertensive heart failure and Zucker fatty diabetic rats) were treated with mycophenolate mofetil (MMF), subjected to renal ischaemia or sham surgery, and monitored via the powerful technique of intravital microscopy. Results. Amelioration of post-ischaemia inflammation with MMF therapy improved long-term renal function, microvascular dysfunction, fibrosis and apoptosis. Conclusion. These data support the hypothesis that the post-ischaemic inflammatory syndrome accelerates diabetic CKD, is a critical determinant of injury, and can be successfully treated.
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