Review
Medicine, Research & Experimental
Lorenzo Flori, Lara Testai, Vincenzo Calderone
Summary: Irisin, a myokine discovered in 2012, is mainly produced in skeletal muscle and influences the browning process of adipose tissue and lipid and energy metabolism. Recent studies suggest its potential may have been underestimated, highlighting the need for further investigation.
Article
Biochemistry & Molecular Biology
Ganna Zaychenko, Olena Stryga, Oksana Sinitsyna, Anna Doroshenko, Oksana Sulaieva, Tetyana Falalyeyeva, Nazarii Kobyliak
Summary: This study demonstrates the potential benefits of using a vaginal gel containing phytoestrogen resveratrol (R) and hyaluronic acid (HA) for the treatment of hypoestrogenic disorders. The gel improves bioavailability and pharmacokinetic properties, and has positive effects on the reproductive system in ovariectomized rats, such as slowing weight gain and reducing fever symptoms.
Review
Biochemistry & Molecular Biology
Jose Antonio Valdes-Gonzalez, Marta Sanchez, Ignacio Moratilla-Rivera, Irene Iglesias, Maria Pilar Gomez-Serranillos
Summary: This review provides an update on the current research on ginseng and its isolated compounds, focusing on their immunomodulation, anti-inflammatory, and anti-cancer effects. The studies cover both isolated components and various extracts obtained from different parts of the ginseng plant.
Review
Clinical Neurology
Neeraja Revi, Aravind Kumar Rengan
Summary: Neurodegenerative disorders are caused by altered protein folding and aggregation, leading to neuronal death; there is a large and increasing number of dementia patients worldwide; polyphenols show potential as therapeutic agents against neuroinflammation associated disorders and are a key area of research.
NEUROLOGICAL SCIENCES
(2021)
Article
Multidisciplinary Sciences
Twahir Begum, Roktim Gogoi, Neelav Sarma, Sudin Kumar, Sudin Kumar Pandey, Mohan Lal
Summary: This study evaluated the chemical composition and biological activities of Kaempferia galanga rhizome essential oil (EMCKG). The results showed that EMCKG has potential as a skin-care agent and for the development of anti-diabetic drugs due to its antioxidant, anti-inflammatory, antimicrobial, and anti-diabetic properties.
Review
Biochemistry & Molecular Biology
Rocco Giordano, Zeinab Saii, Malthe Fredsgaard, Laura Sini Sofia Hulkko, Thomas Bouet Guldbaek Poulsen, Mikkel Eggert Thomsen, Nanna Henneberg, Silvana Maria Zucolotto, Lars Arendt-Nielsen, Jutta Papenbrock, Mette Hedegaard Thomsen, Allan Stensballe
Summary: Pharmacological activities in bioactive plant extracts, particularly key compounds with anti-inflammatory, bactericidal, and pain relief effects, have drawn significant attention for medicinal and cosmetic applications. This systematic review focuses on the availability and potential biomedical applications of bioactive compounds from salt-tolerant plant species, including Aster tripolium, Crithmum maritimum, and Salicornia europaea, known for their traditional medicinal uses and potential future nutraceutical applications.
Review
Biochemistry & Molecular Biology
Ludmila A. Kasatkina, Sonja Rittchen, Eva M. Sturm
Summary: Endocannabinoids are lipid-based retrograde messengers that play crucial roles in brain development, memory formation, mood regulation, and immune cell communication. They interact with cannabinoid receptors to mediate anti-inflammatory, immunomodulatory, and neuroprotective activities, highlighting their therapeutic potential for neuroinflammation and synaptopathy treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Simona Mattova, Patrik Simko, Nicol Urbanska, Terezia Kiskova
Summary: This review provides an overview of the importance of postnatal neurogenesis and highlights the impact of natural compounds on this process. Understanding the interplay between postnatal neurogenesis and natural compounds could provide novel insights into brain health interventions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Erika Plazas, Monica C. M. Avila, Diego R. Munoz, Luis E. S. Cuca
Summary: Complex diseases such as neurodegenerative disorders and cancer pose a significant public health problem. The traditional pharmacotherapy based on a single target has been insufficient, and the emerging multi-target approach shows promise in the search for new drug candidates. Plant-derived isoquinoline alkaloids offer a vast source of multimodal agents with unique structural diversity and a wide range of pharmacological activities. This review provides a comprehensive compilation of the pharmacological relevance and multi-target potential of natural isoquinolines, emphasizing their promising activity in complex diseases.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Microbiology
Clemens Moeller, Lena Heinbockel, Patrick Garidel, Thomas Gutsmann, Karl Mauss, Gunther Weindl, Satoshi Fukuoka, Dominik Loser, Timm Danker, Klaus Brandenburg
Summary: This study analyzed the toxic behavior of Aspidasept and Aspidasept II and their part structures in various cellular models, as well as conducting electrophysiological experiments targeting the hERG channel and experiments on mouse neurobehavior and local lymph nodes. The data provided conclusive information about the potential toxic effects of these peptides, specifying a therapeutic window for their clinical application.
Review
Biochemistry & Molecular Biology
Kamal D. Moudgil, Shivaprasad H. Venkatesha
Summary: Inflammation is a key component of autoimmune diseases, which result from immune system dysregulation. This dysregulation affects the balance between pro-inflammatory and anti-inflammatory mediators, including cytokines, chemokines, and specific cell subsets. Although anti-inflammatory drugs are available, their long-term use and cost often cause severe adverse reactions and hinder effective disease control. Natural products offer promising alternatives, and specific compounds extracted from plants have been extensively studied for their disease-modulating activities. This article focuses on the characteristics, mechanisms of action, and application in animal models and limited clinical trials of 5 well-characterized natural product compounds (Resveratrol, Curcumin, Boswellic acids, Epigallocatechin-3-gallate, and Triptolide) in T cell-mediated diseases such as rheumatoid arthritis, multiple sclerosis, Type 1 diabetes, ulcerative colitis, and psoriasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Md. Rezaul Islam, Maruf Hossain Jony, Gazi Kaifeara Thufa, Shopnil Akash, Puja Sutra Dhar, Md. Mominur Rahman, Tahmina Afroz, Muniruddin Ahmed, Hassan A. Hemeg, Abdur Rauf, Muthu Thiruvengadam, Baskar Venkidasamy
Summary: This article discusses the neuroprotective effects of natural compounds in Huntington's disease (HD) models. Many natural bioactive compounds have been shown to mitigate memory loss and motor coordination impairments caused by 3-nitropropionic acid (3-NP), through reducing lipid peroxidation, increasing antioxidant activity, and enhancing mitochondrial energy generation. Natural products also exhibit neuroprotective properties due to their antioxidant and anti-inflammatory effects, maintenance of mitochondrial function, activation of autophagy, and inhibition of apoptosis.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Denis Sarrouilhe, Norah Defamie, Marc Mesnil
Summary: Serotonin, a biogenic monoamine, plays crucial roles as a neurotransmitter in the central nervous system, local mediator in the gut, and vasoactive agent in the blood. High comorbidity between certain diseases is partly due to shared etiologies involving the serotoninergic system. Environmental neurotoxic substances can impact the serotoninergic system, potentially contributing to the development of various neurological disorders.
Review
Biochemistry & Molecular Biology
Raluca Ioana Teleanu, Adelina-Gabriela Niculescu, Eugenia Roza, Oana Vladacenco, Alexandru Mihai Grumezescu, Daniel Mihai Teleanu
Summary: This paper describes the role of neurotransmitters and their link to relevant neurological conditions. It also provides an overview of detection methods and considerations for modulating neurotransmitters to restore homeostasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Clinical Neurology
Rebecca O'Dwyer, Emma Foster, Ilo Leppik, Patrick Kwan
Summary: With the increasing global aging population, there has been a growing interest in epilepsy in older adults. This article aims to review the literature on the pharmacological treatment of epilepsy in older adults, focusing on issues relevant to those living with comorbid neurodegenerative disorders.
CURRENT OPINION IN NEUROLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Rana Muhammad Bilal, Faiz Ul Hassan, Muhammad Saeed, Majed Rafeeq, Naveed Zahra, Asim Fraz, Salman Saeed, Musarrat Abbass Khan, Hany A. M. Mahgoub, Mayada R. Farag, Mahmoud Alagawany
Summary: Yeast and its products have multiple benefits in broiler diets, including improving immune response, enhancing gut health, and boosting nutrient absorption. They can be used as effective feed additives to replace synthetic antibiotic growth promoters, improving animal welfare and productivity.
ANIMAL BIOTECHNOLOGY
(2023)
Article
Environmental Sciences
Manthar Ali Mallah, Changxing Li, Mukhtiar Ali Mallah, Sobia Noreen, Yang Liu, Muhammad Saeed, He Xi, Bilal Ahmed, Feifei Feng, Ali Asghar Mirjat, Wei Wang, Abdul Jabar, Muhammad Naveed, Jian-Hua Li, Qiao Zhang
Summary: Polycyclic aromatic hydrocarbons (PAHs) are chemical contaminants of environmental significance. PAH pollution mainly comes from anthropogenic sources and can pose a significant threat to human health. Long-term exposure to PAHs can lead to tumor development in multiple organs and increase the risk of lung cancer and cardiovascular diseases. Studies have shown a relationship between PAH exposure, oxidative stress, and atherosclerosis.
Article
Energy & Fuels
Shaukat Khan, Mazhar Ul-Islam, Muhammad Sajjad, Iftikhar Hussain, Muhammad Idrees, Muhammad Saeed, Muhammad Imran, Muhammad Sufyan Javed
Summary: This study reports a low-cost and high-performance cathode material for lithium-sulfur batteries by preparing nitrogen-sulfur co-doped carbon nanosheets anchored on the surface of reduced graphene oxide.
Review
Pharmacology & Pharmacy
Qin-Yuan Li, Mahzaib Munawar, Muhammad Saeed, Ji-Qiang Shen, Muhammad Sajjad Khan, Sobia Noreen, Mahmoud Alagawany, Muhammad Naveed, Asadullah Madni, Chang-Xing Li
Summary: Increasing health consciousness and knowledge about synthetic drug side effects have led to a growing interest in traditional medicines, especially herb-based medicines like Citrullus colocynthis. This herbaceous plant is rich in nutrients and bioactive compounds, offering various medicinal properties such as antioxidative, anti-inflammatory, and even pesticidal effects. Comprehensive research and analysis have shown the potential of C. colocynthis in treating disorders in both humans and animals, highlighting its positive impacts and potential risks on human health, particularly in veterinary and poultry fields.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Urology & Nephrology
Muhammad Naveed, Changxing Li, Awais Ullah Ihsan, Muhammad Shumzaid, Asghar Ali Kamboh, Ali Asghar Mirjat, Muhammad Saeed, Mirza Muhammad Faran Ashraf Baig, Hafiz Muhammad Zubair, Sobia Noreen, Asadullah Madni, Xiaohui Zhou
Summary: The assessment and management of urologic chronic pelvic pain syndrome (UCPPS) is controversial due to the lack of reliable tools for evaluating symptoms and quality of life impact. The etiology is multifactorial, and treatment options are uncertain. The immune system plays an important role in the disease. The UPOINT system can guide treatment and improve symptoms.
Article
Environmental Sciences
Manthar Ali Mallah, Li Changxing, Mukhtiar Ali Mallah, Muhammad Naveed, Yang Liu, Sobia Noreen, He Xi, Wei Wang, Feifei Feng, Qiao Zhang
Summary: This study aimed to investigate the association between urinary PAHs and cardiovascular diseases. The results showed a positive correlation between urinary PAHs and the prevalence of coronary heart disease, angina, heart attack, and stroke.
ENVIRONMENTAL RESEARCH
(2022)
Article
Materials Science, Multidisciplinary
Sobia Noreen, Arslan Maqbool, Irsah Maqbool, Afifa Shafique, Muhammad Muzamil Khan, Yasmeen Junejo, Bilal Ahmed, Maryam Anwar, Asma Majeed, Muhammad Abbas, Muhammad Naveed, Asadullah Madni
Summary: Nanotechnology is the emerging field that focuses on controlling material configuration at a reduced scale, and multifunctional mesoporous silica nanoparticles (MSNPs) have been shown to have great potential in tumor treatment and imaging. Functionalized mesoporous silica materials have rapidly advanced in imaging and therapeutic applications.
MATERIALS CHEMISTRY AND PHYSICS
(2022)
Article
Agriculture, Dairy & Animal Science
Asim Riaz, Muhammad Sajjad Khan, Muhammad Saeed, Asghar Ali Kamboh, Rifat Ullah Khan, Zahid Farooq, Safdar Imran, Muhammad Usman Farid
Summary: Azolla, a nutrient-rich aquatic fern, has various pharmacological effects and can be used in feed and medicine, particularly for liver protection. Adding Azolla to feed can improve poultry performance.
WORLDS POULTRY SCIENCE JOURNAL
(2022)
Review
Instruments & Instrumentation
Sobia Noreen, Jin-Xiang Ma, Muhammad Saeed, Fahad Pervaiz, Muhammad Farhan Hanif, Bilal Ahmed, Muhammad Irshad Farooq, Faizan Akram, Muhammad Safdar, Asadullah Madni, Muhammad Naveed, Li Chang-Xing
Summary: Natural biodegradable polymers play a vital role in transdermal drug delivery systems by controlling drug release rate. They have advantages of availability and affordability, allowing the development of regulated and targeted pharmaceutical delivery systems.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Article
Genetics & Heredity
Sina Salajegheh Tazerji, Fatemeh Shahabinejad, Mahya Tokasi, Mohammad Ali Rad, Muhammad Sajjad Khan, Muhammad Safdar, Krzysztof J. Filipiak, Lukasz Szarpak, Tomasz Dzieciatkowski, Jan Jurgiel, Phelipe Magalhaes Duarte, Md Tanvir Rahman, Md Abdus Sobur, Md Saiful Islam, Adnan Ahmed, Mohamed N. F. Shaheen, Awad A. Shehata, Rasha Gharieb, Mohamed Fawzy, Yashpal Singh Malik, Nagaraj Jaganathasamy, Vinodhkumar Obli Rajendran, Kannan Subbaram, P. Shaik Syed Ali, Sheeza Ali, Saif Ur Rehman, Mehmet Ozaslan, Gulfaraz Khan, Muhammad Saeed, Umair Younas, Safdar Imran, Yasmeen Junejo, Parmida Arabkarami, Unarose Hogan, Alfonso J. Rodriguez-Morales
Summary: This review focused on global data analysis and risk factors associated with morbidity and mortality of coronavirus disease 2019 (COVID-19) from different countries. The findings suggest that males have higher confirmed and death cases compared to females, possibly due to cultural activities and variations in the immune system. Understanding the characteristics of the COVID-19 epidemic is important for mitigating its impact in the future and preparedness for future epidemics.
Review
Rehabilitation
Manthar Ali Mallah, Tahmina Soomro, Sobia Noreen, Mukhtiar Ali, Akriti Kafle, Nafeesa Khatoon, Muhammad Naveed
Summary: Obesity is a severe health concern that is associated with heart failure and cardiovascular disease. It is caused by a metabolic imbalance where more calories are consumed than burnt. Obesity has adverse impacts on the cardiovascular system, including inflammation, atherosclerosis, and high blood pressure. It is also a known risk factor for various diseases.
INTERNATIONAL JOURNAL OF REHABILITATION RESEARCH
(2023)
Article
Immunology
Amna Tahir, Muhammad Furqan Akhtar, Ammara Saleem, Muhammad Naveed, Basiru Olaitan Ajiboye, Fareeha Anwar, Aslam Khan
Summary: PCCR is a traditional herbal medicine used for treating muscular swelling, inflammation, pain, and fever. This study confirmed the anti-inflammatory, analgesic, and neuroprotective effects of PCCR in arthritic rats. PCCR exhibited antioxidant and anti-inflammatory activities, improved oxidative stress, and reduced inflammatory markers in rats with arthritis.
INFLAMMOPHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Muhammad Safdar, Mehmet Ozaslan, Rebaz M. Mustafa, Shukur W. Smail, Samiha S. Khan, Muhammad Sajjad Khan, Muhammad Asad Akhtar, Hafiz Khawar Ali, Umair Younas, Muhammad Saeed, Faisal Siddique, Muhammad Naveed, SaifUr Rehman
Summary: This study explores the association between increased susceptibility and severity in hypertensive COVID-19 patients. The findings suggest that certain SNPs in the ACE2 gene may contribute to the severity of COVID-19 in individuals with hypertension.
JOURNAL OF TAIBAH UNIVERSITY MEDICAL SCIENCES
(2023)
Review
Public, Environmental & Occupational Health
Muhammed Lamin Sambou, Juncheng Dai, Xiaoyu Zhao, Tongtong Hong, Til Bahadur Basnet, Gifty Marley, Alima Sambou, El Hafa Fadoua, Muhammad Naveed
Summary: The study identified 8 significant determinants of VCT service uptake among adults in sub-Saharan Africa (SSA), including lower physical access, older age, higher education level, high knowledge of HIV and VCT awareness, unprotected sexual practices, discussion on HIV among partners and others, other STIs, and divorced/separated status. The findings suggest that HIV interventions and policy initiatives should be tailored to these determinants in order to increase VCT service uptake in SSA.
PUBLIC HEALTH REVIEWS
(2022)