Radioactive nano-oxygen generator enhance anti-tumor radio-immunotherapy by regulating tumor microenvironment and reducing proliferation

A hybrid semiconducting organosilica-based O2 nanoeconomizer for on-demand synergistic photothermally boosted radiotherapy

(2021) Wei Tang et al.   Nature Communications

Recent Advances in Nanomaterial‐Based Nanoplatforms for Chemodynamic Cancer Therapy

(2021) Shu‐Lan Li et al.   ADVANCED FUNCTIONAL MATERIALS

The HIF-1α antisense long non-coding RNA drives a positive feedback loop of HIF-1α mediated transactivation and glycolysis

(2021) Fang Zheng et al.   Nature Communications

A versatile gas-generator promoting drug release and oxygen replenishment for amplifying photodynamic-chemotherapy synergetic anti-tumor effects

(2021) Xiudan Wang et al.   BIOMATERIALS

Therapeutic targeting of the hypoxic tumour microenvironment

(2021) Dean C. Singleton et al.   Nature Reviews Clinical Oncology

Hyperbaric Oxygen Boosts PD‐1 Antibody Delivery and T Cell Infiltration for Augmented Immune Responses Against Solid Tumors

(2021) Xin Liu et al.   Advanced Science

HIPK2 suppresses tumor growth and progression of hepatocellular carcinoma through promoting the degradation of HIF-1α

(2020) Peizhan Chen et al.   ONCOGENE

Targeting Metabolism to Improve the Tumor Microenvironment for Cancer Immunotherapy

(2020) Jackie E. Bader et al.   MOLECULAR CELL

Persistent Regulation of Tumor Hypoxia Microenvironment via a Bioinspired Pt‐Based Oxygen Nanogenerator for Multimodal Imaging‐Guided Synergistic Phototherapy

(2020) Qing You et al.   Advanced Science

Perfluorocarbon@Porphyrin Nanoparticles for Tumor Hypoxia Relief to Enhance Photodynamic Therapy against Liver Metastasis of Colon Cancer

(2020) Xiaolong Liang et al.   ACS Nano

Tumor targeted self-synergistic nanoplatforms for arsenic-sensitized photodynamic therapy

(2020) Ping Yuan et al.   Acta Biomaterialia

Au2Pt-PEG-Ce6 nanoformulation with dual nanozyme activities for synergistic chemodynamic therapy / phototherapy

(2020) Man Wang et al.   BIOMATERIALS

The role of hypoxia‐inducible factor 1 in tumor immune evasion

(2020) Li You et al.   MEDICINAL RESEARCH REVIEWS

Tumor pH and metastasis: a malignant process beyond hypoxia

(2019) Oliver Thews et al.   CANCER AND METASTASIS REVIEWS

Apigenin Combined With Gefitinib Blocks Autophagy Flux and Induces Apoptotic Cell Death Through Inhibition of HIF-1α, c-Myc, p-EGFR, and Glucose Metabolism in EGFR L858R+T790M-Mutated H1975 Cells

(2019) ZiSheng Chen et al.   Frontiers in Pharmacology

A Mesoporous Nanoenzyme Derived from Metal–Organic Frameworks with Endogenous Oxygen Generation to Alleviate Tumor Hypoxia for Significantly Enhanced Photodynamic Therapy

(2019) Dongdong Wang et al.   ADVANCED MATERIALS

Biomimetic Hybrid Nanozymes with Self-Supplied H+ and Accelerated O2 Generation for Enhanced Starvation and Photodynamic Therapy against Hypoxic Tumors

(2019) Xue Yang et al.   NANO LETTERS

Nanozymes-Engineered Metal–Organic Frameworks for Catalytic Cascades-Enhanced Synergistic Cancer Therapy

(2019) Chuang Liu et al.   NANO LETTERS

Hydrogen peroxide inducible clone-5 sustains NADPH oxidase-dependent reactive oxygen species-c-jun N-terminal kinase signaling in hepatocellular carcinoma

(2019) Jia-Ru Wu et al.   Oncogenesis

A novel LncRNA HITT forms a regulatory loop with HIF-1α to modulate angiogenesis and tumor growth

(2019) Xingwen Wang et al.   CELL DEATH AND DIFFERENTIATION

Fate-mapping post-hypoxic tumor cells reveals a ROS-resistant phenotype that promotes metastasis

(2019) Inês Godet et al.   Nature Communications

Hypoxia-tropic nanozymes as oxygen generators for tumor-favoring theranostics

(2019) Fangli Gao et al.   BIOMATERIALS

Combined local immunostimulatory radioisotope therapy and systemic immune checkpoint blockade imparts potent antitumour responses

(2018) Yu Chao et al.   Nature Biomedical Engineering

A biomimetic nanoreactor for synergistic chemiexcited photodynamic therapy and starvation therapy against tumor metastasis

(2018) Zhengze Yu et al.   Nature Communications

Enhanced Cisplatin Chemotherapy by Iron Oxide Nanocarrier-Mediated Generation of Highly Toxic Reactive Oxygen Species

(2017) Ping’an Ma et al.   NANO LETTERS

MnO2Gatekeeper: An Intelligent and O2-Evolving Shell for Preventing Premature Release of High Cargo Payload Core, Overcoming Tumor Hypoxia, and Acidic H2O2-Sensitive MRI

(2016) Zhifang Ma et al.   ADVANCED FUNCTIONAL MATERIALS

Interactions between Myc and MondoA transcription factors in metabolism and tumourigenesis

(2015) Blake R Wilde et al.   BRITISH JOURNAL OF CANCER

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

(2015) Chih-Hao Chang et al.   CELL

Immunological mechanisms of the antitumor effects of supplemental oxygenation

(2015) Stephen M. Hatfield et al.   Science Translational Medicine

HIF Transcription Factors, Inflammation, and Immunity

(2014) Asis Palazon et al.   IMMUNITY

Construction of Ultrastable Porphyrin Zr Metal–Organic Frameworks through Linker Elimination

(2013) Dawei Feng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY