Amyloid beta increases ABCA1 and HMGCR protein expression, and cholesterol synthesis and accumulation in mice neurons and astrocytes

Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease

(2020) Tiantian Guo et al.   Molecular Neurodegeneration

Novel therapeutic strategies for Alzheimer’s disease targeting brain cholesterol homeostasis

(2020) Nikita Patil Samant et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

ApoE Lipidation as a Therapeutic Target in Alzheimer’s Disease

(2020) Maria Fe Lanfranco et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Amyloid-β-independent regulators of tau pathology in Alzheimer disease

(2019) Rik van der Kant et al.   NATURE REVIEWS NEUROSCIENCE

Neuronal Cholesterol Accumulation Induced by Cyp46a1 Down-Regulation in Mouse Hippocampus Disrupts Brain Lipid Homeostasis

(2017) Sophie Ayciriex et al.   Frontiers in Molecular Neuroscience

Potential Mechanisms Linking Cholesterol to Alzheimer's Disease-like Pathology in Rabbit Brain, Hippocampal Organotypic Slices, and Skeletal Muscle

(2017) Othman Ghribi   JOURNAL OF ALZHEIMERS DISEASE

Alzheimer's Disease and the Amyloid-β Peptide

(2017) M. Paul Murphy et al.   JOURNAL OF ALZHEIMERS DISEASE

CYP46A1 inhibition, brain cholesterol accumulation and neurodegeneration pave the way for Alzheimer’s disease

(2015) Fathia Djelti et al.   BRAIN

Endoplasmic Reticulum Stress Mediates Amyloid β Neurotoxicity via Mitochondrial Cholesterol Trafficking

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Astrocyte׳s endogenous apoE generates HDL-like lipoproteins using previously synthesized cholesterol through interaction with ABCA1

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Cholesterol Homeostasis Failure in the Brain: Implications for Synaptic Dysfunction and Cognitive Decline

(2014) Marco Segatto et al.   CURRENT MEDICINAL CHEMISTRY

Cholesterol 24S-Hydroxylase Overexpression Inhibits the Liver X Receptor (LXR) Pathway by Activating Small Guanosine Triphosphate-Binding Proteins (sGTPases) in Neuronal Cells

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ApoE and Aβ in Alzheimer’s Disease: Accidental Encounters or Partners?

(2014) Takahisa Kanekiyo et al.   NEURON

Is It Possible to Improve Memory Function by Upregulation of the Cholesterol 24S-Hydroxylase (CYP46A1) in the Brain?

(2013) Silvia Maioli et al.   PLoS One

ABCA1 increases extracellular ATP to mediate cholesterol efflux to ApoA-I

(2011) Jee Yeon Lee et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Enhanced production of 24S-hydroxycholesterol is not sufficient to drive liver X receptor target genes in vivo

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Mechanism underlying apolipoprotein E (ApoE) isoform-dependent lipid efflux from neural cells in culture

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