Cholesterol 24S-Hydroxylase Overexpression Inhibits the Liver X Receptor (LXR) Pathway by Activating Small Guanosine Triphosphate-Binding Proteins (sGTPases) in Neuronal Cells

Ras inhibition by FTS attenuates brain tumor growth in mice by direct antitumor activity and enhanced reactivity of cytotoxic lymphocytes

(2015) Elizabeta Aizman et al.   Oncotarget

Effects of Liver X Receptor Agonist Treatment on Pulmonary Inflammation and Host Defense

(2014) K. Smoak et al.   JOURNAL OF IMMUNOLOGY

Regulation of Small GTPases by GEFs, GAPs, and GDIs

(2013) Jacqueline Cherfils et al.   PHYSIOLOGICAL REVIEWS

Is It Possible to Improve Memory Function by Upregulation of the Cholesterol 24S-Hydroxylase (CYP46A1) in the Brain?

(2013) Silvia Maioli et al.   PLoS One

Inhibition of rho kinase enhances survival of dopaminergic neurons and attenuates axonal loss in a mouse model of Parkinson's disease

(2012) L. Tonges et al.   BRAIN

Cholesterol loss during glutamate-mediated excitotoxicity

(2012) Alejandro O Sodero et al.   EMBO JOURNAL

Rho GTPases in primary brain tumor malignancy and invasion

(2012) Bassem D. Khalil et al.   JOURNAL OF NEURO-ONCOLOGY

Liver X Receptor Activation Enhances Blood-Brain Barrier Integrity in the Ischemic Brain and Increases the Abundance of ATP-Binding Cassette Transporters ABCB1 and ABCC1 on Brain Capillary Cells

(2011) Ayman ElAli et al.   BRAIN PATHOLOGY

Rab GTPases as regulators of endocytosis, targets of disease and therapeutic opportunities

(2011) JO Agola et al.   CLINICAL GENETICS

Enhanced production of 24S-hydroxycholesterol is not sufficient to drive liver X receptor target genes in vivo

(2011) M. Shafaati et al.   JOURNAL OF INTERNAL MEDICINE

Isoprenoids, small GTPases and Alzheimer's disease

(2010) Gero P. Hooff et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The role of Rho GTPase proteins in CNS neuronal migration

(2010) Eve-Ellen Govek et al.   Developmental Neurobiology

Binding of PDZ-RhoGEF to ATP-binding Cassette Transporter A1 (ABCA1) Induces Cholesterol Efflux through RhoA Activation and Prevention of Transporter Degradation

(2010) Keiichiro Okuhira et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cholesterol-Dependent Kinase Activity Regulates Transmitter Release from Cerebellar Synapses

(2010) A. J. Smith et al.   JOURNAL OF NEUROSCIENCE

Small G Protein Signaling in Neuronal Plasticity and Memory Formation: The Specific Role of Ras Family Proteins

(2010) Xiaojing Ye et al.   NEURON

Rho and Ras GTPases in Axon Growth, Guidance, and Branching

(2010) A. Hall et al.   Cold Spring Harbor Perspectives in Biology

Adeno-associated Virus Gene Therapy With Cholesterol 24-Hydroxylase Reduces the Amyloid Pathology Before or After the Onset of Amyloid Plaques in Mouse Models of Alzheimer's Disease

(2009) Eloise Hudry et al.   MOLECULAR THERAPY

Rab GTPases and their roles in brain neurons and glia

(2008) Ee Ling Ng et al.   BRAIN RESEARCH REVIEWS

Rho Family GTPase Modification and Dependence on CAAXMotif-signaled Posttranslational Modification

(2008) Patrick J. Roberts et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Atorvastatin Inhibits ABCA1 Expression and Cholesterol Efflux in THP-1 Macrophages by an LXR-dependent Pathway

(2008) Guosong Qiu et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Transcriptional regulation of the humanCYP46A1brain-specific expression by Sp transcription factors

(2008) Ins Milagre et al.   JOURNAL OF NEUROCHEMISTRY

Biphasic requirement for geranylgeraniol in hippocampal long-term potentiation

(2008) T. Kotti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA