Glycine-Rich Peptides from FUS Have an Intrinsic Ability to Self-Assemble into Fibers and Networked Fibrils

Mechanistic Inferences From Analysis of Measurements of Protein Phase Transitions in Live Cells

(2021) Ammon E. Posey et al.   JOURNAL OF MOLECULAR BIOLOGY

Biomolecular condensates at the nexus of cellular stress, protein aggregation disease and ageing

(2021) Simon Alberti et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Do polyproline II helix associations modulate biomolecular condensates?

(2021) Miguel Mompeán et al.   FEBS Open Bio

Glycine rich segments adopt polyproline II helices: Implications for biomolecular condensate formation

(2021) M. Mompeán et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Physical Principles Underlying the Complex Biology of Intracellular Phase Transitions

(2020) Jeong-Mo Choi et al.   Annual Review of Biophysics

Valence and patterning of aromatic residues determine the phase behavior of prion-like domains

(2020) Erik W. Martin et al.   SCIENCE

Role of Sheet-Edge Interactions in β-sheet Self-Assembling Peptide Hydrogels

(2020) Jacek K. Wychowaniec et al.   BIOMACROMOLECULES

Composition-dependent thermodynamics of intracellular phase separation

(2020) Joshua A. Riback et al.   NATURE

Identifying sequence perturbations to an intrinsically disordered protein that determine its phase-separation behavior

(2020) Benjamin S. Schuster et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic metastable long-living droplets formed by sticker-spacer proteins

(2020) Srivastav Ranganathan et al.   eLife

FT-IR Spectroscopic Analysis of the Secondary Structures Present during the Desiccation Induced Aggregation of Elastin-Like Polypeptide on Silica

(2020) Jared S. Cobb et al.   ACS Omega

Beyond aggregation: Pathological phase transitions in neurodegenerative disease

(2020) Cécile Mathieu et al.   SCIENCE

Molecular Details of Protein Condensates Probed by Microsecond Long Atomistic Simulations

(2020) Wenwei Zheng et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Considerations and Challenges in Studying Liquid-Liquid Phase Separation and Biomolecular Condensates

(2019) Simon Alberti et al.   CELL

Redox State Controls Phase Separation of the Yeast Ataxin-2 Protein via Reversible Oxidation of Its Methionine-Rich Low-Complexity Domain

(2019) Masato Kato et al.   CELL

Spontaneous driving forces give rise to protein−RNA condensates with coexisting phases and complex material properties

(2019) Steven Boeynaems et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Self‐Assembly in Protein‐Based Bionanomaterials

(2019) Aleksei Solomonov et al.   ISRAEL JOURNAL OF CHEMISTRY

Loss of Dynamic RNA Interaction and Aberrant Phase Separation Induced by Two Distinct Types of ALS/FTD-Linked FUS Mutations

(2019) Amirhossein Ghanbari Niaki et al.   MOLECULAR CELL

LASSI: A lattice model for simulating phase transitions of multivalent proteins

(2019) Jeong-Mo Choi et al.   PLoS Computational Biology

Collapse Transitions of Proteins and the Interplay Among Backbone, Sidechain, and Solvent Interactions

(2018) Alex S. Holehouse et al.   Annual Review of Biophysics

A Molecular Grammar Governing the Driving Forces for Phase Separation of Prion-like RNA Binding Proteins

(2018) Jie Wang et al.   CELL

RGG/RG Motif Regions in RNA Binding and Phase Separation

(2018) P. Andrew Chong et al.   JOURNAL OF MOLECULAR BIOLOGY

Differential solvation of intrinsically disordered linkers drives the formation of spatially organized droplets in ternary systems of linear multivalent proteins

(2018) Tyler S Harmon et al.   NEW JOURNAL OF PHYSICS

RNA buffers the phase separation behavior of prion-like RNA binding proteins

(2018) Shovamayee Maharana et al.   SCIENCE

Atomic structures of low-complexity protein segments reveal kinked β sheets that assemble networks

(2018) Michael P. Hughes et al.   SCIENCE

Different Material States of Pub1 Condensates Define Distinct Modes of Stress Adaptation and Recovery

(2018) Sonja Kroschwald et al.   Cell Reports

Pi-Pi contacts are an overlooked protein feature relevant to phase separation

(2018) Robert McCoy Vernon et al.   eLife

Compositional adaptability in NPM1-SURF6 scaffolding networks enabled by dynamic switching of phase separation mechanisms

(2018) Mylene C. Ferrolino et al.   Nature Communications

Intramolecular Interactions Overcome Hydration to Drive the Collapse Transition of Gly15

(2017) D. Asthagiri et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Phase Separation of C9orf72 Dipeptide Repeats Perturbs Stress Granule Dynamics

(2017) Steven Boeynaems et al.   MOLECULAR CELL

Biomolecular condensates: organizers of cellular biochemistry

(2017) Salman F. Banani et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural and hydrodynamic properties of an intrinsically disordered region of a germ cell-specific protein on phase separation

(2017) Jacob P. Brady et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A rare polyglycine type II-like helix motif in naturally occurring proteins

(2017) Eberhard Warkentin et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Liquid phase condensation in cell physiology and disease

(2017) Yongdae Shin et al.   SCIENCE

Intrinsically disordered linkers determine the interplay between phase separation and gelation in multivalent proteins

(2017) Tyler S Harmon et al.   eLife

Compositional Control of Phase-Separated Cellular Bodies

(2016) Salman F. Banani et al.   CELL

Sequence Determinants of Intracellular Phase Separation by Complex Coacervation of a Disordered Protein

(2016) Chi W. Pak et al.   MOLECULAR CELL

A modular self-assembly approach to functionalised β-sheet peptide hydrogel biomaterials

(2016) Patrick J. S. King et al.   Soft Matter

Phase Separation by Low Complexity Domains Promotes Stress Granule Assembly and Drives Pathological Fibrillization

(2015) Amandine Molliex et al.   CELL

A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation

(2015) Avinash Patel et al.   CELL

To gel or not to gel: correlating molecular gelation with solvent parameters

(2015) Y. Lan et al.   CHEMICAL SOCIETY REVIEWS

Quantitative Assessments of the Distinct Contributions of Polypeptide Backbone Amides versus Side Chain Groups to Chain Expansion via Chemical Denaturation

(2015) Alex S. Holehouse et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Phase Transition of a Disordered Nuage Protein Generates Environmentally Responsive Membraneless Organelles

(2015) Timothy J. Nott et al.   MOLECULAR CELL

Polymer physics of intracellular phase transitions

(2015) Clifford P. Brangwynne et al.   Nature Physics

Nucleic acid-binding specificity of human FUS protein

(2015) Xueyin Wang et al.   NUCLEIC ACIDS RESEARCH

Protein collapse driven against solvation free energy without H-bonds

(2015) Deepti Karandur et al.   PROTEIN SCIENCE

Distinct circular dichroism spectroscopic signatures of polyproline II and unordered secondary structures: Applications in secondary structure analyses

(2014) Jose L. S. Lopes et al.   PROTEIN SCIENCE

Phosphorylation-Regulated Binding of RNA Polymerase II to Fibrous Polymers of Low-Complexity Domains

(2013) Ilmin Kwon et al.   CELL

Cell-free Formation of RNA Granules: Low Complexity Sequence Domains Form Dynamic Fibers within Hydrogels

(2012) Masato Kato et al.   CELL

Getting RNA and Protein in Phase

(2012) Stephanie C. Weber et al.   CELL

Phase transitions in the assembly of multivalent signalling proteins

(2012) Pilong Li et al.   NATURE

Backbone-Driven Collapse in Unfolded Protein Chains

(2011) Daniel P. Teufel et al.   JOURNAL OF MOLECULAR BIOLOGY

Molecular and supramolecular studies on polyglycine and poly-l-proline

(2011) Marina Lorusso et al.   Soft Matter

Domain swapping in materials design

(2010) Radhika P. Nagarkar et al.   BIOPOLYMERS

X-ray Structure of Snow Flea Antifreeze Protein Determined by Racemic Crystallization of Synthetic Protein Enantiomers

(2008) Brad L. Pentelute et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Role of Backbone−Solvent Interactions in Determining Conformational Equilibria of Intrinsically Disordered Proteins

(2008) Hoang T. Tran et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A polymer physics perspective on driving forces and mechanisms for protein aggregation

(2007) Rohit V. Pappu et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS