Estimation of Effective Concentrations Enforced by Complex Linker Architectures from Conformational Ensembles

Nanoscale spatial dependence of avidity in an IgG1 antibody

(2021) Agnieszka Jendroszek et al.   Scientific Reports

Allostery of multidomain proteins with disordered linkers

(2020) Qiaojing Huang et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Predicting secondary structure propensities in IDPs using simple statistics from three-residue fragments

(2020) Alejandro Estaña et al.   JOURNAL OF MOLECULAR BIOLOGY

Conformational Ensembles of an Intrinsically Disordered Protein Consistent with NMR, SAXS, and Single-Molecule FRET

(2020) Gregory-Neal W. Gomes et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Intrinsically disordered linkers control tethered kinases via effective concentration

(2020) Mateusz Dyla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Linker Engineering in the Context of Synthetic Protein Switches and Sensors

(2020) Alexander Gräwe et al.   TRENDS IN BIOTECHNOLOGY

Linker Dependence of Avidity in Multivalent Interactions between Disordered Proteins

(2019) Charlotte S. Sørensen et al.   JOURNAL OF MOLECULAR BIOLOGY

DisProt: intrinsic protein disorder annotation in 2020

(2019) András Hatos et al.   NUCLEIC ACIDS RESEARCH

iFLinkC: an iterative functional linker cloning strategy for the combinatorial assembly and recombination of linker peptides with functional domains

(2019) Alexander Gräwe et al.   NUCLEIC ACIDS RESEARCH

Sequence-to-Conformation Relationships of Disordered Regions Tethered to Folded Domains of Proteins

(2018) Anuradha Mittal et al.   JOURNAL OF MOLECULAR BIOLOGY

Enzyme fusions in biocatalysis - Coupling reactions by pairing enzymes

(2018) Friso Aalbers et al.   CHEMBIOCHEM

Conformational preferences and phase behavior of intrinsically disordered low complexity sequences: insights from multiscale simulations

(2018) Kiersten M Ruff et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Decoupling of size and shape fluctuations in heteropolymeric sequences reconciles discrepancies in SAXS vs. FRET measurements

(2017) Gustavo Fuertes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intrinsically disordered linkers determine the interplay between phase separation and gelation in multivalent proteins

(2017) Tyler S Harmon et al.   eLife

Single-Molecule FRET Spectroscopy and the Polymer Physics of Unfolded and Intrinsically Disordered Proteins

(2016) Benjamin Schuler et al.   Annual Review of Biophysics

A Thiamine-Dependent Enzyme Utilizes an Active Tetrahedral Intermediate in Vitamin K Biosynthesis

(2016) Haigang Song et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Comprehensive structural and dynamical view of an unfolded protein from the combination of single-molecule FRET, NMR, and SAXS

(2016) Mikayel Aznauryan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Influence of length and flexibility of spacers on the binding affinity of divalent ligands

(2015) Susanne Liese et al.   Beilstein Journal of Organic Chemistry

Advanced ensemble modelling of flexible macromolecules using X-ray solution scattering

(2015) Giancarlo Tria et al.   IUCrJ

Acetyl-lysine Binding Site of Bromodomain-Containing Protein 4 (BRD4) Interacts with Diverse Kinase Inhibitors

(2014) Stuart W. J. Ember et al.   ACS Chemical Biology

Exploring Free-Energy Landscapes of Intrinsically Disordered Proteins at Atomic Resolution Using NMR Spectroscopy

(2014) Malene Ringkjøbing Jensen et al.   CHEMICAL REVIEWS

Design and characterization of structured protein linkers with differing flexibilities

(2014) J. S. Klein et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Describing intrinsically disordered proteins at atomic resolution by NMR

(2013) Malene Ringkjøbing Jensen et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Protein Conformational Change Delayed by Steric Hindrance from an N-Linked Glycan

(2013) René Bager et al.   JOURNAL OF MOLECULAR BIOLOGY

Structures of bovine, equine and leporine serum albumin

(2012) Anna Bujacz   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Fusion protein linkers: Property, design and functionality

(2012) Xiaoying Chen et al.   ADVANCED DRUG DELIVERY REVIEWS

Crystal and NMR structures of a Trp-cage mini-protein benchmark for computational fold prediction

(2012) M. Scian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polymer scaling laws of unfolded and intrinsically disordered proteins quantified with single-molecule spectroscopy

(2012) H. Hofmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

On Unsatisfied Hydrogen Bonds in the N-Terminal Subdomain of Villin Headpiece

(2011) Jeffrey W. Brown et al.   JOURNAL OF MOLECULAR BIOLOGY

Using Covalent Dimers of Human Carbonic Anhydrase II To Model Bivalency in Immunoglobulins

(2011) Eric T. Mack et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dependence of Avidity on Linker Length for a Bivalent Ligand–Bivalent Receptor Model System

(2011) Eric T. Mack et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structural analysis of intrinsically disordered proteins by small-angle X-ray scattering

(2011) Pau Bernadó et al.   Molecular BioSystems

p66 -MBD2 coiled-coil interaction and recruitment of Mi-2 are critical for globin gene silencing by the MBD2-NuRD complex

(2011) M. N. Gnanapragasam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sequence Determinants of Compaction in Intrinsically Disordered Proteins

(2010) Joseph A. Marsh et al.   BIOPHYSICAL JOURNAL

Antibody Detection by Using a FRET-Based Protein Conformational Switch

(2010) Misha V. Golynskiy et al.   CHEMBIOCHEM

Biochemistry on a Leash: The Roles of Tether Length and Geometry in Signal Integration Proteins

(2009) David Van Valen et al.   BIOPHYSICAL JOURNAL

The Crystal Structures of the Open and Catalytically Competent Closed Conformation ofEscherichia coliGlycogen Synthase

(2009) Fang Sheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure of Escherichia coli Polynucleotide Phosphorylase Core Bound to RNase E, RNA and Manganese: Implications for Catalytic Mechanism and RNA Degradosome Assembly

(2009) Salima Nurmohamed et al.   JOURNAL OF MOLECULAR BIOLOGY

Statistical Mechanics of the Stability of Multivalent Ligand−Receptor Complexes

(2009) D. J. Diestler et al.   Journal of Physical Chemistry C

Docking for fragment inhibitors of AmpC  -lactamase

(2009) D. G. Teotico et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The effects of conformational heterogeneity on the binding of the Notch intracellular domain to effector proteins: a case of biologically tuned disorder

(2008) Angela Bertagna et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Statistical Thermodynamics of the Stability of Multivalent Ligand-Receptor Complexes

(2008) D. J. Diestler et al.   PHYSICAL REVIEW LETTERS

The first high pH structure ofEscherichia coliaspartate transcarbamoylase

(2008) Kimberly A. Stieglitz et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS