Higher expression of proline dehydrogenase altered mitochondrial function and increased Trypanosoma cruzi differentiation in vitro and in the insect vector

Fatty acid oxidation participates in resistance to nutrient-depleted environments in the insect stages of Trypanosoma cruzi

(2021) Rodolpho Ornitz Oliveira Souza et al.   PLoS Pathogens

The Influence of Environmental Cues on the Development of Trypanosoma cruzi in Triatominae Vector

(2020) Raíssa de Fátima Pimentel Melo et al.   Frontiers in Cellular and Infection Microbiology

Trypanosoma cruzi synthesizes proline via a Δ1-pyrroline-5-carboxylate reductase whose activity is fine-tuned by NADPH cytosolic pools

(2020) Letícia Marchese et al.   BIOCHEMICAL JOURNAL

Chagas disease

(2018) José A Pérez-Molina et al.   LANCET

L-Glutamine uptake is developmentally regulated and is involved in metacyclogenesis in Trypanosoma cruzi

(2018) Flávia S. Damasceno et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Metabolomic profiling reveals a finely tuned, starvation-induced metabolic switch inTrypanosoma cruziepimastigotes

(2017) María Julia Barisón et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proline Metabolism is Essential for Trypanosoma brucei brucei Survival in the Tsetse Vector

(2017) Brian S. Mantilla et al.   PLoS Pathogens

Proline Metabolism in Cell Regulation and Cancer Biology: Recent Advances and Hypotheses

(2017) James M. Phang   ANTIOXIDANTS & REDOX SIGNALING

Role of Δ1-Pyrroline-5-Carboxylate Dehydrogenase Supports Mitochondrial Metabolism and Host-Cell Invasion ofTrypanosoma cruzi

(2015) Brian S. Mantilla et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chagas’ Disease

(2015) Caryn Bern   NEW ENGLAND JOURNAL OF MEDICINE

Monitoring of the Parasite Load in the Digestive Tract of Rhodnius prolixus by Combined qPCR Analysis and Imaging Techniques Provides New Insights into the Trypanosome Life Cycle

(2015) Felipe de Almeida Dias et al.   PLoS Neglected Tropical Diseases

Proliferation and Differentiation of Trypanosoma cruzi inside Its Vector Have a New Trigger: Redox Status

(2015) Natália P. Nogueira et al.   PLoS One

Proline Modulates the Trypanosoma cruzi Resistance to Reactive Oxygen Species and Drugs through a Novel D, L-Proline Transporter

(2014) Melisa Sayé et al.   PLoS One

Proline Dehydrogenase Regulates Redox State and Respiratory Metabolism in Trypanosoma cruzi

(2013) Lisvane Silva Paes et al.   PLoS One

Essential regulation of cell bioenergetics in Trypanosoma brucei by the mitochondrial calcium uniporter

(2013) Guozhong Huang et al.   Nature Communications

Tryparedoxin peroxidases and superoxide dismutases expression as well as ROS release are related to Trypanosoma cruzi epimastigotes growth phases

(2012) Eduardo F. Peloso et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

The Uniqueness of the Trypanosoma cruzi Mitochondrion: Opportunities to Target New Drugs Against Chagas Disease

(2011) Lisvane Silva Paes et al.   CURRENT PHARMACEUTICAL DESIGN

Role of Trypanosoma cruzi peroxiredoxins in mitochondrial bioenergetics

(2011) Eduardo de Figueiredo Peloso et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Modulation of Trypanosoma rangeli ecto-phosphatase activity by hydrogen peroxide

(2009) Daniela Cosentino-Gomes et al.   FREE RADICAL BIOLOGY AND MEDICINE

Use of L-Proline and ATP Production by Trypanosoma cruzi Metacyclic Forms as Requirements for Host Cell Invasion

(2009) R. M. Martins et al.   INFECTION AND IMMUNITY

Unraveling Δ1-Pyrroline-5-Carboxylate-Proline Cycle in Plants by Uncoupled Expression of Proline Oxidation Enzymes

(2009) Gad Miller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glucose uptake in the mammalian stages of Trypanosoma cruzi

(2009) Ariel M. Silber et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Actions of a Proline Analogue, L-Thiazolidine-4-Carboxylic Acid (T4C), on Trypanosoma cruzi

(2009) Anahí Magdaleno et al.   PLoS One