Trypanosoma cruzi synthesizes proline via a Δ1-pyrroline-5-carboxylate reductase whose activity is fine-tuned by NADPH cytosolic pools

Characterisation of a putative glutamate 5-kinase from Leishmania donovani

(2018) Natasha Sienkiewicz et al.   FEBS Journal

L-Glutamine uptake is developmentally regulated and is involved in metacyclogenesis in Trypanosoma cruzi

(2018) Flávia S. Damasceno et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

The glutamine synthetase of Trypanosoma cruzi is required for its resistance to ammonium accumulation and evasion of the parasitophorous vacuole during host-cell infection

(2018) Marcell Crispim et al.   PLoS Neglected Tropical Diseases

The Metabolism of Proline as Microenvironmental Stress Substrate

(2018) James M. Phang et al.   JOURNAL OF NUTRITION

Metabolomic profiling reveals a finely tuned, starvation-induced metabolic switch inTrypanosoma cruziepimastigotes

(2017) María Julia Barisón et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Integration of proteomics and metabolomics to elucidate metabolic adaptation in Leishmania

(2017) Snezhana Akpunarlieva et al.   Journal of Proteomics

Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells

(2017) Ilaria Elia et al.   Nature Communications

Proline Metabolism is Essential for Trypanosoma brucei brucei Survival in the Tsetse Vector

(2017) Brian S. Mantilla et al.   PLoS Pathogens

Proline Metabolism in Cell Regulation and Cancer Biology: Recent Advances and Hypotheses

(2017) James M. Phang   ANTIOXIDANTS & REDOX SIGNALING

The active transport of histidine and its role in ATP production in Trypanosoma cruzi

(2016) M. J. Barisón et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Phytotoxicity of aminobisphosphonates targeting bothδ1-pyrroline-5-carboxylate reductase and glutamine synthetase

(2016) Samuele Giberti et al.   PEST MANAGEMENT SCIENCE

Role of Δ1-Pyrroline-5-Carboxylate Dehydrogenase Supports Mitochondrial Metabolism and Host-Cell Invasion ofTrypanosoma cruzi

(2015) Brian S. Mantilla et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proline biosynthesis augments tumor cell growth and aerobic glycolysis: involvement of pyridine nucleotides

(2015) Wei Liu et al.   Scientific Reports

Evolution of plant δ1-pyrroline-5-carboxylate reductases from phylogenetic and structural perspectives

(2015) Giuseppe Forlani et al.   Frontiers in Plant Science

The structure of Medicago truncatula δ1-pyrroline-5-carboxylate reductase provides new insights into regulation of proline biosynthesis in plants

(2015) Milosz Ruszkowski et al.   Frontiers in Plant Science

Evolution of proline biosynthesis: enzymology, bioinformatics, genetics, and transcriptional regulation

(2014) Yosef Fichman et al.   BIOLOGICAL REVIEWS

Δ1-pyrroline-5-carboxylate reductase fromArabidopsis thaliana: stimulation or inhibition by chloride ions and feedback regulation by proline depend on whether NADPH or NADH acts as co-substrate

(2014) Samuele Giberti et al.   NEW PHYTOLOGIST

Proline Modulates the Trypanosoma cruzi Resistance to Reactive Oxygen Species and Drugs through a Novel D, L-Proline Transporter

(2014) Melisa Sayé et al.   PLoS One

Proline Dehydrogenase Regulates Redox State and Respiratory Metabolism in Trypanosoma cruzi

(2013) Lisvane Silva Paes et al.   PLoS One

Essential regulation of cell bioenergetics in Trypanosoma brucei by the mitochondrial calcium uniporter

(2013) Guozhong Huang et al.   Nature Communications

Coenzyme preference of Streptococcus pyogenes δ1-pyrroline-5-carboxylate reductase: evidence supporting NADPH as the physiological electron donor

(2011) Davide Petrollino et al.   AMINO ACIDS

Functional characterization of NADP-dependent isocitrate dehydrogenase isozymes from Trypanosoma cruzi

(2011) Alejandro E. Leroux et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

The biological significance of substrate inhibition: A mechanism with diverse functions

(2010) Michael C. Reed et al.   BIOESSAYS

Comparative studies on the biochemical properties of  the malic enzymes from Trypanosoma cruzi and Trypanosoma brucei

(2010) Alejandro E. Leroux et al.   FEMS MICROBIOLOGY LETTERS

Use of L-Proline and ATP Production by Trypanosoma cruzi Metacyclic Forms as Requirements for Host Cell Invasion

(2009) R. M. Martins et al.   INFECTION AND IMMUNITY

Unraveling Δ1-Pyrroline-5-Carboxylate-Proline Cycle in Plants by Uncoupled Expression of Proline Oxidation Enzymes

(2009) Gad Miller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional characterization of stage-specific aminotransferases from trypanosomatids

(2009) Daniela Marciano et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

TriTrypDB: a functional genomic resource for the Trypanosomatidae

(2009) Martin Aslett et al.   NUCLEIC ACIDS RESEARCH

Actions of a Proline Analogue, L-Thiazolidine-4-Carboxylic Acid (T4C), on Trypanosoma cruzi

(2009) Anahí Magdaleno et al.   PLoS One

Proline: a multifunctional amino acid

(2009) László Szabados et al.   TRENDS IN PLANT SCIENCE

Proline as a stress protectant in yeast: physiological functions, metabolic regulations, and biotechnological applications

(2008) Hiroshi Takagi   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Characterization of a Helicobacter hepaticus putA Mutant Strain in Host Colonization and Oxidative Stress

(2008) N. Krishnan et al.   INFECTION AND IMMUNITY

Biochemical characterization of stage-specific isoforms of aspartate aminotransferases from Trypanosoma cruzi and Trypanosoma brucei

(2008) Daniela Marciano et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY