Characterization of hydrodynamic stress in ambr250® bioreactor system and its impact on mammalian cell culture

Monitoring cell productivity for the production of recombinant proteins by flow cytometry: An effective application using the cold capture assay

(2021) Katharina V. Meyer et al.   ENGINEERING IN LIFE SCIENCES

Design and development of a new ambr250® bioreactor vessel for improved cell and gene therapy applications

(2021) Marco Rotondi et al.   BIOTECHNOLOGY LETTERS

Demonstrating the Manufacture of Human CAR‐T Cells in an Automated Stirred‐Tank Bioreactor

(2020) Elena Costariol et al.   Biotechnology Journal

Perfusion Cultures Require Optimum Respiratory ATP Supply to Maximize Cell Specific and Volumetric Productivities

(2019) Max Becker et al.   BIOTECHNOLOGY AND BIOENGINEERING

Scale‐down model qualification of ambr® 250 high‐throughput mini‐bioreactor system for two commercial‐scale mAb processes

(2019) Matthew Manahan et al.   BIOTECHNOLOGY PROGRESS

Experimental and CFD physical characterization of animal cell bioreactors: From micro- to production scale

(2018) Thomas K. Villiger et al.   BIOCHEMICAL ENGINEERING JOURNAL

Proteomic analysis of micro-scale bioreactors as scale-down model for a mAb producing CHO industrial fed-batch platform

(2018) Vania Bertrand et al.   JOURNAL OF BIOTECHNOLOGY

Controlling the time evolution of mAb N-linked glycosylation, Part I: Microbioreactor experiments

(2016) Thomas K. Villiger et al.   BIOTECHNOLOGY PROGRESS

High-throughput profiling of nucleotides and nucleotide sugars to evaluate their impact on antibody N-glycosylation

(2016) Thomas K. Villiger et al.   JOURNAL OF BIOTECHNOLOGY

Experimental determination of maximum effective hydrodynamic stress in multiphase flow using shear sensitive aggregates

(2015) Thomas K. Villiger et al.   AICHE JOURNAL

Pilot-scale verification of maximum tolerable hydrodynamic stress for mammalian cell culture

(2015) Benjamin Neunstoecklin et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Efficient high-throughput biological process characterization: Definitive screening design with the Ambr250 bioreactor system

(2015) Mitchell Tai et al.   BIOTECHNOLOGY PROGRESS

Determination of the maximum operating range of hydrodynamic stress in mammalian cell culture

(2015) Benjamin Neunstoecklin et al.   JOURNAL OF BIOTECHNOLOGY

Use of a small molecule cell cycle inhibitor to control cell growth and improve specific productivity and product quality of recombinant proteins in CHO cell cultures

(2014) Zhimei Du et al.   BIOTECHNOLOGY AND BIOENGINEERING

High-throughput nucleoside phosphate monitoring in mammalian cell fed-batch cultivation using quantitative matrix-assisted laser desorption/ionization time-of-flight mass spectrometry

(2014) Robert F. Steinhoff et al.   Biotechnology Journal

A cost-effective and reliable method to predict mechanical stress in single-use and standard pumps

(2014) Ina Dittler et al.   ENGINEERING IN LIFE SCIENCES

Adaptation for survival: Phenotype and transcriptome response of CHO cells to elevated stress induced by agitation and sparging

(2014) Jochen B. Sieck et al.   JOURNAL OF BIOTECHNOLOGY

Experimental Characterization of Breakage Rate of Colloidal Aggregates in Axisymmetric Extensional Flow

(2014) Debashish Saha et al.   LANGMUIR

Determination of maximum turbulent energy dissipation rate generated by a rushton impeller through large eddy simulation

(2013) Miroslav Soos et al.   AICHE JOURNAL

Automated disposable small scale reactor for high throughput bioprocess development: A proof of concept study

(2013) Rachel Bareither et al.   BIOTECHNOLOGY AND BIOENGINEERING

Scale-down studies for assessing the impact of different stress parameters on growth and product quality during animal cell culture

(2013) Alvin W. Nienow et al.   CHEMICAL ENGINEERING RESEARCH & DESIGN

Development of a Scale-Down Model of hydrodynamic stress to study the performance of an industrial CHO cell line under simulated production scale bioreactor conditions

(2012) Jochen B. Sieck et al.   JOURNAL OF BIOTECHNOLOGY

Minimizing hydrodynamic stress in mammalian cell culture through the lobed Taylor-Couette bioreactor

(2011) Robin Sorg et al.   Biotechnology Journal

The potential of hydrodynamic damage to animal cells of industrial relevance: current understanding

(2011) Weiwei Hu et al.   CYTOTECHNOLOGY

Experimental and Modeling Study of Breakage and Restructuring of Open and Dense Colloidal Aggregates

(2011) Yogesh M. Harshe et al.   LANGMUIR

Breakage Rate of Colloidal Aggregates in Shear Flow through Stokesian Dynamics

(2011) Yogesh M. Harshe et al.   LANGMUIR

Effect of flow field heterogeneity in coagulators on aggregate size and structure

(2010) Lyonel Ehrl et al.   AICHE JOURNAL

Induction of mammalian cell death by simple shear and extensional flows

(2009) Timm Tanzeglock et al.   BIOTECHNOLOGY AND BIOENGINEERING

Physiological responses of CHO cells to repetitive hydrodynamic stress

(2009) Ruben Godoy-Silva et al.   BIOTECHNOLOGY AND BIOENGINEERING

Scale-Up Considerations Based on Studies at the Bench Scale in Stirred Bioreactors

(2009) Alvin William Nienow   JOURNAL OF CHEMICAL ENGINEERING OF JAPAN

Interpretation of Light Scattering and Turbidity Measurements in Aggregated Systems: Effect of Intra-Cluster Multiple-Light Scattering

(2009) Miroslav Soos et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Aggregate Breakup in a Contracting Nozzle

(2009) Miroslav Soos et al.   LANGMUIR

Breakup of dense colloidal aggregates under hydrodynamic stresses

(2009) Alessio Zaccone et al.   PHYSICAL REVIEW E

Roadmap for implementation of quality by design (QbD) for biotechnology products

(2009) Anurag S. Rathore   TRENDS IN BIOTECHNOLOGY

Evaluation of the effect of chronic hydrodynamical stresses on cultures of suspensed CHO-6E6 cells

(2008) Ruben Godoy-Silva et al.   BIOTECHNOLOGY AND BIOENGINEERING

Effect of shear rate on aggregate size and morphology investigated under turbulent conditions in stirred tank

(2008) Miroslav Soos et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Dynamic Response Studies on Aggregation and Breakage Dynamics of Colloidal Dispersions in Stirred Tanks

(2008) M. Soos et al.   JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY

Dependence of Aggregate Strength, Structure, and Light Scattering Properties on Primary Particle Size under Turbulent Conditions in Stirred Tank

(2008) Lyonel Ehrl et al.   LANGMUIR