Icariin inhibits isoproterenol-induced cardiomyocyte hypertropic injury through activating autophagy via the AMPK/mTOR signaling pathway

A new route to regulating AMPK activity

(2021) Sarah Crunkhorn   NATURE REVIEWS DRUG DISCOVERY

Icariin Ameliorates Diabetic Cardiomyopathy Through Apelin/Sirt3 Signalling to Improve Mitochondrial Dysfunction

(2020) Tingjuan Ni et al.   Frontiers in Pharmacology

Icariin alleviates rheumatoid arthritis via regulating miR-223-3p/NLRP3 signalling axis

(2020) Zhi-Ming Wu et al.   AUTOIMMUNITY

Autophagy and cardiac diseases: Therapeutic potential of natural products

(2020) Xiaoqian Wu et al.   MEDICINAL RESEARCH REVIEWS

Autophagy in Human Diseases

(2020) Noboru Mizushima et al.   NEW ENGLAND JOURNAL OF MEDICINE

Biological Functions of Autophagy Genes: A Disease Perspective

(2019) Beth Levine et al.   CELL

Molecular biomarkers in cardiac hypertrophy

(2019) Liu Zhu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Icariin promotes osteogenic differentiation of bone marrow stromal cells and prevents bone loss in OVX mice via activating autophagy

(2019) Xiaoxiao Liang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Autophagy and cardiac aging

(2019) Shigeki Miyamoto   CELL DEATH AND DIFFERENTIATION

Angiogenic and MMPs modulatory effects of icariin improved cutaneous wound healing in rats

(2019) Wangkheirakpam Ramdas Singh et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Icariin Ameliorates Amyloid Pathologies by Maintaining Homeostasis of Autophagic Systems in Aβ1–42-Injected Rats

(2019) Xia Jiang et al.   NEUROCHEMICAL RESEARCH

Mechanisms of physiological and pathological cardiac hypertrophy

(2018) Michinari Nakamura et al.   Nature Reviews Cardiology

Galectins Control MTOR and AMPK in Response to Lysosomal Damage to Induce Autophagy

(2018) Jingyue Jia et al.   Autophagy

Icariin protects cardiomyocytes against ischaemia/reperfusion injury by attenuating sirtuin 1-dependent mitochondrial oxidative damage

(2018) Bing Wu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Epidemiology of cardiovascular disease in China: current features and implications

(2018) Dong Zhao et al.   Nature Reviews Cardiology

Chikusetsu saponin IVa attenuates isoprenaline-induced myocardial fibrosis in mice through activation autophagy mediated by AMPK/mTOR/ULK1 signaling

(2018) Luopei Wang et al.   PHYTOMEDICINE

Icariin ameliorates angiotensin II-induced cerebrovascular remodeling by inhibiting Nox2-containing NADPH oxidase activation

(2018) Huanhuan Dong et al.   Human Cell

Icariin attenuated oxidative stress induced-cardiac apoptosis by mitochondria protection and ERK activation

(2016) Yao-Hong Song et al.   BIOMEDICINE & PHARMACOTHERAPY

Puerarin prevents cardiac hypertrophy induced by pressure overload through activation of autophagy

(2015) Bei Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Icariin Acts as a Potential Agent for Preventing Cardiac Ischemia/Reperfusion Injury

(2015) Minghe Zhai et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Mechanotransduction in Cardiac Hypertrophy and Failure

(2015) R. C. Lyon et al.   CIRCULATION RESEARCH

AMPK inhibits cardiac hypertrophy by promoting autophagy via mTORC1

(2014) Yanh Li et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Icariin Protects Rat Cardiac H9c2 Cells from Apoptosis by Inhibiting Endoplasmic Reticulum Stress

(2013) Qiufang Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

AMPK and mTOR in Cellular Energy Homeostasis and Drug Targets

(2011) Ken Inoki et al.   Annual Review of Pharmacology and Toxicology

Autophagy in the Cellular Energetic Balance

(2011) Rajat Singh et al.   Cell Metabolism

Icariin attenuates cardiac remodelling through down-regulating myocardial apoptosis and matrix metalloproteinase activity in rats with congestive heart failure

(2011) Yao-Hong Song et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Icariin induces mouse embryonic stem cell differentiation into beating functional cardiomyocytes

(2010) Xiaodong Sun et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY