Icariin ameliorates angiotensin II-induced cerebrovascular remodeling by inhibiting Nox2-containing NADPH oxidase activation

3,7-Bis(2-hydroxyethyl)icaritin, a potent inhibitor of phosphodiesterase-5, prevents monocrotaline-induced pulmonary arterial hypertension via NO/cGMP activation in rats

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Icariin influences cardiac remodeling following myocardial infarction by regulating the CD147/MMP-9 pathway

(2018) Yu Shi et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Chicoric acid prevents PDGF-BB-induced VSMC dedifferentiation, proliferation and migration by suppressing ROS/NFκB/mTOR/P70S6K signaling cascade

(2018) Qing-Bo Lu et al.   Redox Biology

MitoKATP channels promote the proliferation of hypoxic human pulmonary artery smooth muscle cells via the ROS/HIF/miR‑210/ISCU signaling pathway

(2017) Hongling Hu et al.   Experimental and Therapeutic Medicine

FGF21 represses cerebrovascular aging via improving mitochondrial biogenesis and inhibiting p53 signaling pathway in an AMPK-dependent manner

(2016) Xiao-Mei Wang et al.   EXPERIMENTAL CELL RESEARCH

Caffeic acid phenethyl ester alleviates asthma by regulating the airway microenvironment via the ROS-responsive MAPK/Akt pathway

(2016) Yuan Ma et al.   FREE RADICAL BIOLOGY AND MEDICINE

PGC-1  limits angiotensin II-induced rat vascular smooth muscle cells proliferation via attenuating NOX1-mediated generation of reactive oxygen species

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Pharmacological effects and pharmacokinetic properties of icariin, the major bioactive component in Herba Epimedii

(2015) Chenrui Li et al.   LIFE SCIENCES

Transcriptome and Molecular Endocrinology Aspects of Epicardial Adipose Tissue in Cardiovascular Diseases: A Systematic Review and Meta-Analysis of Observational Studies

(2015) Zhila Maghbooli et al.   Biomed Research International

NRROS negatively regulates reactive oxygen species during host defence and autoimmunity

(2014) Rajkumar Noubade et al.   NATURE

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Reactive oxygen species, Nox and angiotensin II in angiogenesis: implications for retinopathy

(2013) Jennifer L. Wilkinson-Berka et al.   CLINICAL SCIENCE

Angiotensin-Generated Reactive Oxygen Species in Brain and Pathogenesis of Cardiovascular Diseases

(2012) Samuel H.H. Chan et al.   ANTIOXIDANTS & REDOX SIGNALING

Downregulation of TMEM16A Calcium-Activated Chloride Channel Contributes to Cerebrovascular Remodeling During Hypertension by Promoting Basilar Smooth Muscle Cell Proliferation

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Metabolic stress, reactive oxygen species, and arrhythmia

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Icariin attenuates cardiac remodelling through down-regulating myocardial apoptosis and matrix metalloproteinase activity in rats with congestive heart failure

(2011) Yao-Hong Song et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Heart Disease and Stroke Statistics—2011 Update

(2010) Véronique L. Roger et al.   CIRCULATION

Angiotensin II–Induced Vascular Smooth Muscle Cell Migration and Growth Are Mediated by Cytochrome P450 1B1–Dependent Superoxide Generation

(2010) Fariborz A. Yaghini et al.   HYPERTENSION

Tempol, a superoxide dismutase mimetic, prevents cerebral vessel remodeling in hypertensive rats

(2010) Paulo Wagner Pires et al.   MICROVASCULAR RESEARCH

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(2009) François Feihl et al.   CURRENT HYPERTENSION REPORTS

Oxidative stress in vascular disease: causes, defense mechanisms and potential therapies

(2008) Ulrich Förstermann   Nature clinical practice. Cardiovascular medicine