CDK9 inhibition blocks the initiation of PINK1-PRKN-mediated mitophagy by regulating the SIRT1-FOXO3-BNIP3 axis and enhances the therapeutic effects involving mitochondrial dysfunction in hepatocellular carcinoma

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

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PINK1‐Dependent Mitophagy Regulates the Migration and Homing of Multiple Myeloma Cells via the MOB1B‐Mediated Hippo‐YAP/TAZ Pathway

(2020) Shengjun Fan et al.   Advanced Science

Role and Mechanisms of Mitophagy in Liver Diseases

(2020) Xiaowen Ma et al.   Cells

Oroxylin a promotes PGC-1α/Mfn2 signaling to attenuate hepatocyte pyroptosis via blocking mitochondrial ROS in alcoholic liver disease

(2020) Jun Kai et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitophagy promotes sorafenib resistance through hypoxia-inducible ATAD3A dependent Axis

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Inhibition of PINK1/Parkin-dependent mitophagy sensitizes multidrug-resistant cancer cells to B5G1, a new betulinic acid analog

(2019) Nan Yao et al.   Cell Death & Disease

LATS2 overexpression attenuates the therapeutic resistance of liver cancer HepG2 cells to sorafenib-mediated death via inhibiting the AMPK–Mfn2 signaling pathway

(2019) Jie Song et al.   Cancer Cell International

FBS/BSA media concentration determines CCCP’s ability to depolarize mitochondria and activate PINK1-PRKN mitophagy

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Thermosensitive hydrogels for sustained-release of sorafenib and selenium nanoparticles for localized synergistic chemoradiotherapy

(2019) Lan Zheng et al.   BIOMATERIALS

Inhibition of PI3K/mTOR increased the sensitivity of hepatocellular carcinoma cells to cisplatin via interference with mitochondrial‐lysosomal crosstalk

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USP33 deubiquitinates PRKN/parkin and antagonizes its role in mitophagy

(2019) Kaifeng Niu et al.   Autophagy

What sustains the multidrug resistance phenotype beyond ABC efflux transporters? Looking beyond the tip of the iceberg

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Targeting Autophagy in Cancer: Recent Advances and Future Directions

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NR4A1 aggravates the cardiac microvascular ischemia reperfusion injury through suppressing FUNDC1-mediated mitophagy and promoting Mff-required mitochondrial fission by CK2α

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Pathogenesis of cardiac ischemia reperfusion injury is associated with CK2α-disturbed mitochondrial homeostasis via suppression of FUNDC1-related mitophagy

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Developing the next generation of graphene-based platforms for cancer therapeutics: The potential role of reactive oxygen species

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Mitophagy-driven metabolic switch reprograms stem cell fate

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Targeting CDK9 Reactivates Epigenetically Silenced Genes in Cancer

(2018) Hanghang Zhang et al.   CELL

Sorafenib targets the mitochondrial electron transport chain complexes and ATP synthase to activate the PINK1–Parkin pathway and modulate cellular drug response

(2017) Conggang Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitophagy Controls the Activities of Tumor Suppressor p53 to Regulate Hepatic Cancer Stem Cells

(2017) Kai Liu et al.   MOLECULAR CELL

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(2017) Nikolaos D Georgakopoulos et al.   Nature Chemical Biology

A fluorescence-based imaging method to measure in vitro and in vivo mitophagy using mt-Keima

(2017) Nuo Sun et al.   Nature Protocols

Oroxylin A activates PKM1/HNF4 alpha to induce hepatoma differentiation and block cancer progression

(2017) Libin Wei et al.   Cell Death & Disease

Oroxylin A suppresses the development and growth of colorectal cancer through reprogram of HIF1α-modulated fatty acid metabolism

(2017) Ting Ni et al.   Cell Death & Disease

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(2016) Daniel J Klionsky et al.   Autophagy

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BNIP3 Protein Suppresses PINK1 Kinase Proteolytic Cleavage to Promote Mitophagy

(2016) Tongmei Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Melatonin-induced increase in sensitivity of human hepatocellular carcinoma cells to sorafenib is associated with reactive oxygen species production and mitophagy

(2016) Néstor Prieto-Domínguez et al.   JOURNAL OF PINEAL RESEARCH

Parkin and mitophagy in cancer

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Tumor suppressor functions of BNIP3 and mitophagy

(2015) Aparajita H Chourasia et al.   Autophagy

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(2015) Nurmaa Dashzeveg et al.   CANCER LETTERS

Oroxylin A regulates glucose metabolism in response to hypoxic stress with the involvement of Hypoxia-inducible factor-1 in human hepatoma HepG2 cells

(2015) Qinsheng Dai et al.   MOLECULAR CARCINOGENESIS

Promotion of mitochondrial energy metabolism during hepatocyte apoptosis in a rat model of acute liver failure

(2015) LI-YAN CHEN et al.   Molecular Medicine Reports

Oroxylin A inhibits glycolysis-dependent proliferation of human breast cancer via promoting SIRT3-mediated SOD2 transcription and HIF1α destabilization

(2015) L Wei et al.   Cell Death & Disease

Tumor Vessel Normalization by Chloroquine Independent of Autophagy

(2014) Hannelore Maes et al.   CANCER CELL

Poly(ADP-Ribose) Polymerase-1 Causes Mitochondrial Damage and Neuron Death Mediated by Bnip3

(2014) P. Lu et al.   JOURNAL OF NEUROSCIENCE

SIRT1 Positively Regulates Autophagy and Mitochondria Function in Embryonic Stem Cells Under Oxidative Stress

(2014) Xuan Ou et al.   STEM CELLS

Loss of iron triggers PINK1/Parkin-independent mitophagy

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Cytosolic p53 inhibits Parkin-mediated mitophagy and promotes mitochondrial dysfunction in the mouse heart

(2013) Atsushi Hoshino et al.   Nature Communications

Chloroquine sensitizes breast cancer cells to chemotherapy independent of autophagy

(2012) Paola Maycotte et al.   Autophagy

SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function

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A Sensitive and Quantitative Technique for Detecting Autophagic Events Based on Lysosomal Delivery

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Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL

(2010) Seok Min Jin et al.   JOURNAL OF CELL BIOLOGY

Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney

(2010) Shinji Kume et al.   JOURNAL OF CLINICAL INVESTIGATION