Mitochondrial redox signaling in O2-sensing chemoreceptor cells

Lactate sensing mechanisms in arterial chemoreceptor cells

(2021) Hortensia Torres-Torrelo et al.   Nature Communications

Mitochondrial Succinate Metabolism and Reactive Oxygen Species Are Important but Not Essential for Eliciting Carotid Body and Ventilatory Responses to Hypoxia in the Rat

(2021) Agnieszka Swiderska et al.   Antioxidants

Hypoxia and Innate Immunity: Keeping Up with the HIFsters

(2020) Sean P. Colgan et al.   Annual Review of Immunology

Cytochrome c Oxidase Subunit 4 Isoform Exchange Results in Modulation of Oxygen Affinity

(2020) David Pajuelo Reguera et al.   Cells

Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

(2020) Helmut Sies et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ndufs2, A Core Subunit of Mitochondrial Complex I, Is Essential for Acute Oxygen-Sensing and Hypoxic Pulmonary Vasoconstriction

(2019) Kimberly J Dunham-Snary et al.   CIRCULATION RESEARCH

Evolution Shapes the Gene Expression Response to Oxidative Stress

(2019) Rima Siauciunaite et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Logic of Carotid Body Connectivity to the Brain

(2019) Tymoteusz Zera et al.   PHYSIOLOGY

Physiology of the Carotid Body: From Molecules to Disease

(2019) Patricia Ortega-Sáenz et al.   Annual Review of Physiology

Redox regulation of tyrosine kinase signalling: more than meets the eye

(2019) Christopher M Dustin et al.   JOURNAL OF BIOCHEMISTRY

Metabolic regulation of Kv channels and cardiac repolarization by Kvβ2 subunits

(2019) Peter J. Kilfoil et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Acute O 2 Sensing: Role of Coenzyme QH 2 /Q Ratio and Mitochondrial ROS Compartmentalization

(2018) Ignacio Arias-Mayenco et al.   Cell Metabolism

Variable role of carotid bodies in cardiovascular responses to exercise, hypoxia and hypercapnia in spontaneously hypertensive rats

(2018) Wioletta Pijacka et al.   JOURNAL OF PHYSIOLOGY-LONDON

Mitochondria control acute and chronic responses to hypoxia

(2017) G.S. McElroy et al.   EXPERIMENTAL CELL RESEARCH

Production of superoxide and hydrogen peroxide from specific mitochondrial sites under different bioenergetic conditions

(2017) Hoi-Shan Wong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gene expression analyses reveal metabolic specifications in acute O2 -sensing chemoreceptor cells

(2017) Lin Gao et al.   JOURNAL OF PHYSIOLOGY-LONDON

Acute oxygen sensing by the carotid body: a rattlebag of molecular mechanisms

(2017) Ryan J. Rakoczy et al.   JOURNAL OF PHYSIOLOGY-LONDON

Translating carotid body function into clinical medicine

(2017) Rodrigo Iturriaga   JOURNAL OF PHYSIOLOGY-LONDON

Oxygen sensing by the carotid body: mechanisms and role in adaptation to hypoxia

(2016) José López-Barneo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Mitochondrial generation of superoxide and hydrogen peroxide as the source of mitochondrial redox signaling

(2016) Martin D. Brand   FREE RADICAL BIOLOGY AND MEDICINE

Carotid Body Ablation Abrogates Hypertension and Autonomic Alterations Induced by Intermittent Hypoxia in RatsNovelty and Significance

(2016) Rodrigo Del Rio et al.   HYPERTENSION

Single cell transcriptome analysis of mouse carotid body glomus cells

(2016) Ting Zhou et al.   JOURNAL OF PHYSIOLOGY-LONDON

O 2 sensing, mitochondria and ROS signaling: The fog is lifting

(2016) Gregory B. Waypa et al.   MOLECULAR ASPECTS OF MEDICINE

Structure of mammalian respiratory complex I

(2016) Jiapeng Zhu et al.   NATURE

Atomic structure of the entire mammalian mitochondrial complex I

(2016) Karol Fiedorczuk et al.   NATURE

Real-time monitoring of basal H2O2 levels with peroxiredoxin-based probes

(2016) Bruce Morgan et al.   Nature Chemical Biology

Oxygen Sensing by Arterial Chemoreceptors Depends on Mitochondrial Complex I Signaling

(2015) M. Carmen Fernández-Agüera et al.   Cell Metabolism

Regulation of ventilatory sensitivity and carotid body proliferation in hypoxia by the PHD2/HIF-2 pathway

(2015) Emma J. Hodson et al.   JOURNAL OF PHYSIOLOGY-LONDON

Mechanistic insight from the crystal structure of mitochondrial complex I

(2015) V. Zickermann et al.   SCIENCE

Redox Regulation of Ion Channels

(2014) Ivan Bogeski et al.   ANTIOXIDANTS & REDOX SIGNALING

Synaptic and paracrine mechanisms at carotid body arterial chemoreceptors

(2014) Colin A. Nurse   JOURNAL OF PHYSIOLOGY-LONDON

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS

(2014) Edward T. Chouchani et al.   NATURE

Superoxide Generated at Mitochondrial Complex III Triggers Acute Responses to Hypoxia in the Pulmonary Circulation

(2013) Gregory B. Waypa et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Oxygen Sensing, Hypoxia-Inducible Factors, and Disease Pathophysiology

(2013) Gregg L. Semenza   Annual Review of Pathology-Mechanisms of Disease

Oxidative Modulation of Voltage-Gated Potassium Channels

(2013) Nirakar Sahoo et al.   ANTIOXIDANTS & REDOX SIGNALING

Redox regulation of protein kinases

(2013) Thu H. Truong et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Role of the Carotid Body in the Pathophysiology of Heart Failure

(2013) Harold D. Schultz et al.   CURRENT HYPERTENSION REPORTS

Inhibitors of ROS production by the ubiquinone-binding site of mitochondrial complex I identified by chemical screening

(2013) Adam L. Orr et al.   FREE RADICAL BIOLOGY AND MEDICINE

NDUFAF7 Methylates Arginine 85 in the NDUFS2 Subunit of Human Complex I

(2013) Virginie F. Rhein et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Responses of glomus cells to hypoxia and acidosis

(2013) Keith J. Buckler   JOURNAL OF PHYSIOLOGY-LONDON

Cellular properties and chemosensory responses of the human carotid body

(2013) Patricia Ortega-Sáenz et al.   JOURNAL OF PHYSIOLOGY-LONDON

Carotid Body Denervation

(2013) Blair D. Johnson et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Carotid Chemoreceptor Ablation Improves Survival in Heart Failure

(2013) Rodrigo Del Rio et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Crystal structure of the entire respiratory complex I

(2013) Rozbeh Baradaran et al.   NATURE

The carotid body as a putative therapeutic target for the treatment of neurogenic hypertension

(2013) Fiona D. McBryde et al.   Nature Communications

Autocrine and paracrine actions of ATP in rat carotid body

(2012) Amy Tse et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Mitochondrial complex II is essential for hypoxia-induced pulmonary vasoconstriction of intra- but not of pre-acinar arteries

(2012) Renate Paddenberg et al.   CARDIOVASCULAR RESEARCH

Physiological Roles of Mitochondrial Reactive Oxygen Species

(2012) Laura A. Sena et al.   MOLECULAR CELL

Modulation of K2P3.1 (TASK-1), K2P9.1 (TASK-3), and TASK-1/3 heteromer by reactive oxygen species

(2012) Justin R. Papreck et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Inhibition of rat carotid body glomus cells TASK-like channels by acute hypoxia is enhanced by chronic intermittent hypoxia

(2012) Fernando C. Ortiz et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Unraveling the Biological Roles of Reactive Oxygen Species

(2011) Michael P. Murphy et al.   Cell Metabolism

Superoxide Is Produced by the Reduced Flavin in Mitochondrial Complex I

(2011) Kenneth R. Pryde et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evidence for Two Sites of Superoxide Production by Mitochondrial NADH-Ubiquinone Oxidoreductase (Complex I)

(2011) Jason R. Treberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The sites and topology of mitochondrial superoxide production

(2010) Martin D. Brand   EXPERIMENTAL GERONTOLOGY

Peroxynitrite Is the Major Species Formed from Different Flux Ratios of Co-generated Nitric Oxide and Superoxide

(2010) Jacek Zielonka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Carotid body chemosensory responses in mice deficient of TASK channels

(2010) Patricia Ortega-Sáenz et al.   JOURNAL OF GENERAL PHYSIOLOGY

Nox2 redox signaling maintains essential cell populations in the brain

(2010) Bryan C Dickinson et al.   Nature Chemical Biology

Redox signaling and reactive oxygen species in hypoxic pulmonary vasoconstriction

(2010) Beate Fuchs et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Elevated mitochondrial superoxide contributes to enhanced chemoreflex in heart failure rabbits

(2009) Yanfeng Ding et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Ion Channel Regulation by AMPK

(2009) A. Mark Evans et al.   Annals of the New York Academy of Sciences

Breathing at high altitude

(2009) Vincent Joseph et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Hypoxia Triggers Subcellular Compartmental Redox Signaling in Vascular Smooth Muscle Cells

(2009) Gregory B. Waypa et al.   CIRCULATION RESEARCH

Mitochondrial reactive oxygen species regulate hypoxic signaling

(2009) Robert B Hamanaka et al.   CURRENT OPINION IN CELL BIOLOGY

Carotid body and cardiorespiratory alterations in intermittent hypoxia: the oxidative link

(2009) R. Del Rio et al.   EUROPEAN RESPIRATORY JOURNAL

Direct oxidation of boronates by peroxynitrite: Mechanism and implications in fluorescence imaging of peroxynitrite

(2009) Adam Sikora et al.   FREE RADICAL BIOLOGY AND MEDICINE

Heteromeric TASK-1/TASK-3 is the major oxygen-sensitive background K+channel in rat carotid body glomus cells

(2009) Donghee Kim et al.   JOURNAL OF PHYSIOLOGY-LONDON

The Inhibition of TREK2 Channel by an Oxidizing Agent, 5,5'-dithio-bis (2-nitrobenzoic acid), via Interaction with the C-terminus Distal to the 353rd Amino Acid

(2009) Kyoung Sun Park et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

The cerebral effects of ascent to high altitudes

(2009) Mark H Wilson et al.   LANCET NEUROLOGY

Reactive oxygen species-dependent endothelin signaling is required for augmented hypoxic sensory response of the neonatal carotid body by intermittent hypoxia

(2008) Anita Pawar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

NOX4 Regulates ROS Levels Under Normoxic and Hypoxic Conditions, Triggers Proliferation, and Inhibits Apoptosis in Pulmonary Artery Adventitial Fibroblasts

(2008) Shu Li et al.   ANTIOXIDANTS & REDOX SIGNALING

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

(2008) William G. Kaelin et al.   MOLECULAR CELL

ΔΨm-Dependent and -independent production of reactive oxygen species by rat brain mitochondria

(2003) Tatyana V. Votyakova et al.   JOURNAL OF NEUROCHEMISTRY