Redox regulation of tyrosine kinase signalling: more than meets the eye

Kinase-Inactivated EGFR Is Required for the Survival of Wild-Type EGFR-Expressing Cancer Cells Treated with Tyrosine Kinase Inhibitors

(2019) Rintu Thomas et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Protein Lipidation: Occurrence, Mechanisms, Biological Functions, and Enabling Technologies

(2018) Hong Jiang et al.   CHEMICAL REVIEWS

Cysteine perthiosulfenic acid (Cys-SSOH): A novel intermediate in thiol-based redox signaling?

(2018) David E. Heppner et al.   Redox Biology

Oxidative stress in chronic lung disease: From mitochondrial dysfunction to dysregulated redox signaling

(2018) Albert van der Vliet et al.   MOLECULAR ASPECTS OF MEDICINE

Direct cysteine sulfenylation drives activation of the Src kinase

(2018) David E. Heppner et al.   Nature Communications

A Dimerization Function in the Intrinsically Disordered N-Terminal Region of Src

(2018) Danislav S. Spassov et al.   Cell Reports

The KIM-family protein-tyrosine phosphatases use distinct reversible oxidation intermediates: Intramolecular or intermolecular disulfide bond formation

(2017) Luciana E. S. F. Machado et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Assay to visualize specific protein oxidation reveals spatio-temporal regulation of SHP2

(2017) Ryouhei Tsutsumi et al.   Nature Communications

Why Nature Chose Selenium

(2016) Hans J. Reich et al.   ACS Chemical Biology

Acrolein and thiol-reactive electrophiles suppress allergen-induced innate airway epithelial responses by inhibition of DUOX1 and EGFR

(2016) Karamatullah Danyal et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Airway epithelial dual oxidase 1 mediates allergen-induced IL-33 secretion and activation of type 2 immune responses

(2016) Milena Hristova et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The NADPH Oxidases DUOX1 and NOX2 Play Distinct Roles in Redox Regulation of Epidermal Growth Factor Receptor Signaling

(2016) David E. Heppner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tyrosine kinase FYN negatively regulates NOX4 in cardiac remodeling

(2016) Shouji Matsushima et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibition of DHHC20-Mediated EGFR Palmitoylation Creates a Dependence on EGFR Signaling

(2016) Kristin B. Runkle et al.   MOLECULAR CELL

The Redox Code

(2015) Dean P. Jones et al.   ANTIOXIDANTS & REDOX SIGNALING

TGFβ1 rapidly activates Src through a non-canonical redox signaling mechanism

(2015) Hongqiao Zhang et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Modification by covalent reaction or oxidation of cysteine residues in the tandem-SH2 domains of ZAP-70 and Syk can block phosphopeptide binding

(2015) Patrick R. Visperas et al.   BIOCHEMICAL JOURNAL

Acquired EGFR C797S mutation mediates resistance to AZD9291 in non–small cell lung cancer harboring EGFR T790M

(2015) Kenneth S Thress et al.   NATURE MEDICINE

Fyn is a redox sensor involved in solar ultraviolet light-induced signal transduction in skin carcinogenesis

(2015) J-E Kim et al.   ONCOGENE

ROS Function in Redox Signaling and Oxidative Stress

(2014) Michael Schieber et al.   CURRENT BIOLOGY

Cellular mechanisms and physiological consequences of redox-dependent signalling

(2014) Kira M. Holmström et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

AZD9291, an Irreversible EGFR TKI, Overcomes T790M-Mediated Resistance to EGFR Inhibitors in Lung Cancer

(2014) D. A. E. Cross et al.   Cancer Discovery

Regulation of Protein Tyrosine Phosphatase Oxidation in Cell Adhesion and Migration

(2013) Jeroen Frijhoff et al.   ANTIOXIDANTS & REDOX SIGNALING

Circles within circles: crosstalk between protein Ser/Thr/Tyr-phosphorylation and Met oxidation

(2013) R Rao et al.   BMC BIOINFORMATICS

Redox regulation of protein kinases

(2013) Thu H. Truong et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Redox regulation of protein kinases

(2013) Aoife Corcoran et al.   FEBS Journal

ATP-Mediated Transactivation of the Epidermal Growth Factor Receptor in Airway Epithelial Cells Involves DUOX1-Dependent Oxidation of Src and ADAM17

(2013) Derek Sham et al.   PLoS One

Covalent EGFR inhibitor analysis reveals importance of reversible interactions to potency and mechanisms of drug resistance

(2013) P. A. Schwartz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Structural Basis for Control of Eukaryotic Protein Kinases

(2012) Jane A. Endicott et al.   Annual Review of Biochemistry

Redox Regulation of Epidermal Growth Factor Receptor Signaling through Cysteine Oxidation

(2012) Thu H. Truong et al.   BIOCHEMISTRY

Identification of a redox-sensitive switch within the JAK2 catalytic domain

(2012) John K. Smith et al.   FREE RADICAL BIOLOGY AND MEDICINE

Src binds cortactin through an SH2 domain cystine-mediated linkage

(2012) J. V. Evans et al.   JOURNAL OF CELL SCIENCE

S-Nitrosylation of EGFR and Src Activates an Oncogenic Signaling Network in Human Basal-Like Breast Cancer

(2012) C. H. Switzer et al.   MOLECULAR CANCER RESEARCH

Formation and Signaling Actions of Electrophilic Lipids

(2011) Francisco J. Schopfer et al.   CHEMICAL REVIEWS

Hyperglycemia Enhances IGF-I-Stimulated Src Activation via Increasing Nox4-Derived Reactive Oxygen Species in a PKC -Dependent Manner in Vascular Smooth Muscle Cells

(2011) G. Xi et al.   DIABETES

Peroxiredoxin II Is an Essential Antioxidant Enzyme that Prevents the Oxidative Inactivation of VEGF Receptor-2 in Vascular Endothelial Cells

(2011) Dong Hoon Kang et al.   MOLECULAR CELL

Lyn is a redox sensor that mediates leukocyte wound attraction in vivo

(2011) Sa Kan Yoo et al.   NATURE

Peroxide-dependent sulfenylation of the EGFR catalytic site enhances kinase activity

(2011) Candice E Paulsen et al.   Nature Chemical Biology

The resurgence of covalent drugs

(2011) Juswinder Singh et al.   NATURE REVIEWS DRUG DISCOVERY

Protein Modification by Acrolein: Formation and Stability of Cysteine Adducts

(2009) Jian Cai et al.   CHEMICAL RESEARCH IN TOXICOLOGY

S-Nitrosylation at Cysteine 498 of c-Src Tyrosine Kinase Regulates Nitric Oxide-mediated Cell Invasion

(2009) Mohammad Aminur Rahman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Redox Regulation of the Human Dual Specificity Phosphatase YVH1 through Disulfide Bond Formation

(2009) Christopher A. Bonham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential trafficking of Src, Lyn, Yes and Fyn is specified by the state of palmitoylation in the SH4 domain

(2009) I. Sato et al.   JOURNAL OF CELL SCIENCE

Redox regulation of anoikis resistance of metastatic prostate cancer cells: key role for Src and EGFR-mediated pro-survival signals

(2009) E Giannoni et al.   ONCOGENE

Direct and specific inactivation of protein tyrosine kinases in the Src and FGFR families by reversible cysteine oxidation

(2009) D. J. Kemble et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The cysteine-cluster motif of c-Src: Its role for the heavy metal-mediated activation of kinase

(2008) Takeshi Senga et al.   CANCER SCIENCE

Redox regulation of anoikis: reactive oxygen species as essential mediators of cell survival

(2008) E Giannoni et al.   CELL DEATH AND DIFFERENTIATION

N-acetyl-l-cysteine fosters inactivation and transfer to endolysosomes of c-Src

(2008) Ewa K. Krasnowska et al.   FREE RADICAL BIOLOGY AND MEDICINE

Redox-based regulation of signal transduction: Principles, pitfalls, and promises

(2008) Yvonne M.W. Janssen-Heininger et al.   FREE RADICAL BIOLOGY AND MEDICINE

S-Nitrosylation of the epidermal growth factor receptor: A regulatory mechanism of receptor tyrosine kinase activity

(2008) Maribel Murillo-Carretero et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nox4 NAD(P)H Oxidase Mediates Src-dependent Tyrosine Phosphorylation of PDK-1 in Response to Angiotensin II

(2008) Karen Block et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CysteineS-Nitrosylation Protects Protein-tyrosine Phosphatase 1B against Oxidation-induced Permanent Inactivation

(2008) Yi-Yun Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY