METTL3-mediated m6A modification of ATG7 regulates autophagy-GATA4 axis to promote cellular senescence and osteoarthritis progression

METTL3 Promotes Activation and Inflammation of FLSs Through the NF-κB Signaling Pathway in Rheumatoid Arthritis

(2021) Wen Shi et al.   Frontiers in Medicine

METTL3 promotes IL‐1β–induced degeneration of endplate chondrocytes by driving m6A‐dependent maturation of miR‐126‐5p

(2020) Liang Xiao et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

METTL3 counteracts premature aging via m6A-dependent stabilization of MIS12 mRNA

(2020) Zeming Wu et al.   NUCLEIC ACIDS RESEARCH

Advances in the profiling of N6-methyladenosine (m6A) modifications

(2020) Hong-xiang Zheng et al.   BIOTECHNOLOGY ADVANCES

Biological Functions of Autophagy Genes: A Disease Perspective

(2019) Beth Levine et al.   CELL

METTL3 and ALKBH5 oppositely regulate m6A modification of TFEB mRNA, which dictates the fate of hypoxia/reoxygenation-treated cardiomyocytes

(2019) Huiwen Song et al.   Autophagy

Where, When, and How: Context-Dependent Functions of RNA Methylation Writers, Readers, and Erasers

(2019) Hailing Shi et al.   MOLECULAR CELL

Estrogen prevents articular cartilage destruction in a mouse model of AMPK deficiency via ERK-mTOR pathway

(2019) Yuxiang Ge et al.   Annals of Translational Medicine

Lysosomes as dynamic regulators of cell and organismal homeostasis

(2019) Andrea Ballabio et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Agephagy – Adapting Autophagy for Health During Aging

(2019) Eleanor R. Stead et al.   Frontiers in Cell and Developmental Biology

Functions of N6-methyladenosine and its role in cancer

(2019) Liuer He et al.   Molecular Cancer

m6A RNA modification controls autophagy through upregulating ULK1 protein abundance

(2018) Shouheng Jin et al.   CELL RESEARCH

mRNA circularization by METTL3–eIF3h enhances translation and promotes oncogenesis

(2018) Junho Choe et al.   NATURE

m6A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer

(2018) Jun Liu et al.   NATURE CELL BIOLOGY

Steps in Mechanotransduction Pathways that Control Cell Morphology

(2018) Haguy Wolfenson et al.   Annual Review of Physiology

NSUN2-Mediated m5C Methylation and METTL3/METTL14-Mediated m6A Methylation Cooperatively Enhance p21 Translation

(2017) Qiu Li et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

RNA m6A methylation regulates the ultraviolet-induced DNA damage response

(2017) Yang Xiang et al.   NATURE

Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

(2017) Ok Hee Jeon et al.   NATURE MEDICINE

The N6-methyladenosine (m6A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells

(2017) Ly P Vu et al.   NATURE MEDICINE

Autophagy signal transduction by ATG proteins: from hierarchies to networks

(2015) Sebastian Wesselborg et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Stem cells in degenerative orthopaedic pathologies: effects of aging on therapeutic potential

(2015) Kivanc Atesok et al.   KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY

Osteoarthritis

(2015) S Glyn-Jones et al.   LANCET

Chondrosenescence: Definition, hallmarks and potential role in the pathogenesis of osteoarthritis

(2015) Ali Mobasheri et al.   MATURITAS

Cellular senescence in aging and age-related disease: from mechanisms to therapy

(2015) Bennett G Childs et al.   NATURE MEDICINE

Aging-related inflammation in osteoarthritis

(2015) M.A. Greene et al.   OSTEOARTHRITIS AND CARTILAGE

The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4

(2015) C. Kang et al.   SCIENCE

The dynamic epitranscriptome: N6-methyladenosine and gene expression control

(2014) Kate D. Meyer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Perturbation of m6A Writers Reveals Two Distinct Classes of mRNA Methylation at Internal and 5′ Sites

(2014) Schraga Schwartz et al.   Cell Reports

N6-methyladenosine-dependent regulation of messenger RNA stability

(2013) Xiao Wang et al.   NATURE

NSun2-Mediated Cytosine-5 Methylation of Vault Noncoding RNA Determines Its Processing into Regulatory Small RNAs

(2013) Shobbir Hussain et al.   Cell Reports

The Interplay between NLRs and Autophagy in Immunity and Inflammation

(2013) Leticia A. M. Carneiro et al.   Frontiers in Immunology

Effects of aging on articular cartilage homeostasis

(2012) Martin Lotz et al.   BONE

Autophagy: A New Therapeutic Target in Cartilage Injury and Osteoarthritis

(2012) Martin Lotz et al.   JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS

Feedback Regulation of Transcriptional Termination by the Mammalian Circadian Clock PERIOD Complex

(2012) K. Padmanabhan et al.   SCIENCE

Lifetime Risk and Age at Diagnosis of Symptomatic Knee Osteoarthritis in the US

(2012) Elena Losina et al.   ARTHRITIS CARE & RESEARCH

A New Definition of Aging?

(2012) Thomas Flatt   Frontiers in Genetics

Autophagy activation by rapamycin reduces severity of experimental osteoarthritis

(2011) Beatriz Caramés et al.   ANNALS OF THE RHEUMATIC DISEASES

Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritis

(2010) Beatriz Caramés et al.   ARTHRITIS AND RHEUMATISM

Regulation Mechanisms and Signaling Pathways of Autophagy

(2009) Congcong He et al.   Annual Review of Genetics

Mitochondrial Turnover and Aging of Long-Lived Postmitotic Cells: The Mitochondrial–Lysosomal Axis Theory of Aging

(2009) Alexei Terman et al.   ANTIOXIDANTS & REDOX SIGNALING