“Fix and Click” for Assay of Sphingolipid Signaling in Single Primary Human Intestinal Epithelial Cells

Cancer Statistics, 2021

(2021) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Optimisation of high-speed lipidome analysis by nanoflow ultrahigh-performance liquid chromatography-tandem mass spectrometry: Application to identify candidate biomarkers for four different cancers

(2021) Gwang Bin Lee et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Exercise-induced recovery of plasma lipids perturbed by ageing with nanoflow UHPLC-ESI-MS/MS

(2020) Kang Uk Kim et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Silicon Photomultipliers as a Low-Cost Fluorescence Detector for Capillary Electrophoresis

(2020) Brae V. Petersen et al.   ANALYTICAL CHEMISTRY

In vitro generation of self-renewing human intestinal epithelia over planar and shaped collagen hydrogels

(2020) Samuel S. Hinman et al.   Nature Protocols

Multiplexed and single cell tracing of lipid metabolism

(2019) Christoph Thiele et al.   NATURE METHODS

Preserving single cells in space and time for analytical assays

(2019) Luke A. Gallion et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

Nano-LC/NSI MS Refines Lipidomics by Enhancing Lipid Coverage, Measurement Sensitivity, and Linear Dynamic Range

(2018) Niklas Danne-Rasche et al.   ANALYTICAL CHEMISTRY

Click reactions with functional sphingolipids

(2018) Julian Fink et al.   BIOLOGICAL CHEMISTRY

Click Chemistry in Sphingolipid Research

(2018) Eduardo Izquierdo et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Traceless synthesis of ceramides in living cells reveals saturation-dependent apoptotic effects

(2018) Andrew K. Rudd et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

“Fix and assay”: separating in-cellulo sphingolipid reactions from analytical assay in time and space using an aldehyde-based fixative

(2018) Angela Proctor et al.   ANALYST

Analysis of lipoprotein-specific lipids in patients with acute coronary syndrome by asymmetrical flow field-flow fractionation and nanoflow liquid chromatography-tandem mass spectrometry

(2018) Jae Hyun Lee et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Chemical fixation to arrest phospholipid signaling for chemical cytometry

(2017) Angela Proctor et al.   JOURNAL OF CHROMATOGRAPHY A

Comprehensive identification of sphingolipid species by in silico retention time and tandem mass spectral library

(2017) Hiroshi Tsugawa et al.   Journal of Cheminformatics

Defective Sphingosine-1-phosphate metabolism is a druggable target in Huntington’s disease

(2017) Alba Di Pardo et al.   Scientific Reports

An LC/MS/MS method for the simultaneous determination of individual sphingolipid species in B cells

(2016) Si Mi et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Therapeutic potential of targeting sphingosine kinases and sphingosine 1-phosphate in hematological malignancies

(2016) C Evangelisti et al.   LEUKEMIA

Acid ceramidase is upregulated in AML and represents a novel therapeutic target

(2016) Su-Fern Tan et al.   Oncotarget

Analysis of sphingosine kinase activity in single natural killer cells from peripheral blood

(2015) Alexandra J. Dickinson et al.   Integrative Biology

Quantitative Profiling of Long-Chain Bases by Mass Tagging and Parallel Reaction Monitoring

(2015) Christer S. Ejsing et al.   PLoS One

Single-cell sphingosine kinase activity measurements in primary leukemia

(2014) Alexandra J. Dickinson et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Comprehensive analysis of lipids in biological systems by liquid chromatography-mass spectrometry

(2014) Tomas Cajka et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

Automated Capillary Electrophoresis System for Fast Single-Cell Analysis

(2013) Alexandra J. Dickinson et al.   ANALYTICAL CHEMISTRY

Alkyne lipids as substrates for click chemistry-based in vitro enzymatic assays

(2013) Anne Gaebler et al.   JOURNAL OF LIPID RESEARCH

Tracing Fatty Acid Metabolism by Click Chemistry

(2012) Christoph Thiele et al.   ACS Chemical Biology

Metabolic Cytometry: Capillary Electrophoresis with Two-Color Fluorescence Detection for the Simultaneous Study of Two Glycosphingolipid Metabolic Pathways in Single Primary Neurons

(2012) David C. Essaka et al.   ANALYTICAL CHEMISTRY

Translating Genomics to the Clinic: Implications of Cancer Heterogeneity

(2012) N. Samuel et al.   CLINICAL CHEMISTRY

Single Cell Ganglioside Catabolism in Primary Cerebellar Neurons and Glia

(2012) David C. Essaka et al.   NEUROCHEMICAL RESEARCH

Many Ceramides

(2011) Yusuf A. Hannun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lysophosphatidylcholine as an effector of fatty acid-induced insulin resistance

(2011) Myoung Sook Han et al.   JOURNAL OF LIPID RESEARCH

Sphingosine-1-phosphate signaling and its role in disease

(2011) Michael Maceyka et al.   TRENDS IN CELL BIOLOGY

Dihydroceramide desaturase activity is modulated by oxidative stress

(2010) Jolanta Idkowiak-Baldys et al.   BIOCHEMICAL JOURNAL

Mammalian ceramide synthases

(2010) Michal Levy et al.   IUBMB LIFE

A rapid and quantitative LC-MS/MS method to profile sphingolipids

(2010) Max Scherer et al.   JOURNAL OF LIPID RESEARCH

Ceramide acyl chain length markedly influences miscibility with palmitoyl sphingomyelin in bilayer membranes

(2009) Bodil Westerlund et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Use of high performance liquid chromatography-electrospray ionization-tandem mass spectrometry for the analysis of ceramide-1-phosphate levels

(2009) Dayanjan S. Wijesinghe et al.   JOURNAL OF LIPID RESEARCH

Determination of Sphingosine Kinase Activity for Cellular Signaling Studies

(2008) Katherine J. Lee et al.   ANALYTICAL CHEMISTRY

A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia

(2008) S. W. Paugh et al.   BLOOD

Targeting SphK1 as a New Strategy against Cancer

(2008) Dai Shida et al.   CURRENT DRUG TARGETS