Advances in the development of antimicrobial peptides and proteins for inhaled therapy

Dry Powder Pharmaceutical Biologics for Inhalation Therapy

(2021) Rachel Yoon Kyung Chang et al.   ADVANCED DRUG DELIVERY REVIEWS

Nebulization of Vancomycin Provides Higher Lung Tissue Concentrations than Intravenous Administration in Ventilated Female Piglets with Healthy Lungs

(2020) Cristiane Luchesi de Mello Morais et al.   ANESTHESIOLOGY

Phase I, Dose-Escalating Study of the Safety and Pharmacokinetics of Inhaled Dry-Powder Vancomycin (AeroVanc) in Volunteers and Patients with Cystic Fibrosis: a New Approach to Therapy for Methicillin-Resistant Staphylococcus aureus

(2020) Grant Waterer et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antimicrobial Peptide-Loaded Nanoparticles as Inhalation Therapy for Pseudomonas aeruginosa Infections

(2020) Chiara Falciani et al.   International Journal of Nanomedicine

In vivo deposition study of a new generation nebuliser utilising hybrid resonant acoustic (HYDRA) technology

(2020) Philip Chi Lip Kwok et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Efficient optimization of high-dose formulation of novel lyophilizates for dry powder inhalation by the combination of response surface methodology and time-of-flight measurement

(2020) Ryo Ohori et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Enhanced therapeutic index of an antimicrobial peptide in mice by increasing safety and activity against multidrug-resistant bacteria

(2020) Y. P. Di et al.   Science Advances

Therapeutic efficacy of novel antimicrobial peptide AA139-nanomedicines in a multidrug-resistant Klebsiella pneumoniae pneumonia-septicemia model in rats

(2020) Hessel van der Weide et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

High frequency acoustic nebulization for pulmonary delivery of antibiotic alternatives against Staphylococcus aureus

(2020) Susan Marqus et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

An amphipathic peptide with antibiotic activity against multidrug-resistant Gram-negative bacteria

(2020) Alysha G. Elliott et al.   Nature Communications

Lung and general health effects of Toll-like receptor-4 (TLR4)-interacting SPA4 peptide

(2020) Shanjana Awasthi et al.   BMC Pulmonary Medicine

Comparison between Colistin Sulfate Dry Powder and Solution for Pulmonary Delivery

(2020) Frédéric Tewes et al.   Pharmaceutics

An Update on Antimicrobial Peptides (AMPs) and Their Delivery Strategies for Wound Infections

(2020) Viorica Patrulea et al.   Pharmaceutics

The Anti-Pseudomonal Peptide D-BMAP18 Is Active in Cystic Fibrosis Sputum and Displays Anti-Inflammatory In Vitro Activity

(2020) Margherita Degasperi et al.   Microorganisms

Can bacteriophage endolysins be nebulised for inhalation delivery against Streptococcus pneumoniae?

(2020) Yuncheng Wang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Pseudomonas aeruginosa in cystic fibrosis: A chronic cheater

(2019) Christopher M. Waters et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effective delivery of the anti-mycobacterial peptide NZX in mesoporous silica nanoparticles

(2019) Erik Tenland et al.   PLoS One

TLR4-interacting SPA4 peptide improves host defense and alleviates tissue injury in a mouse model of Pseudomonas aeruginosa lung infection

(2019) Shanjana Awasthi et al.   PLoS One

Mycobacterium tuberculosis infection of host cells in space and time

(2019) Claudio Bussi et al.   FEMS MICROBIOLOGY REVIEWS

Efficacy of Intranasal Administration of the Recombinant Endolysin SAL200 in a Lethal Murine Staphylococcus aureus Pneumonia Model

(2019) Ji Yun Bae et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Isolation of phage lysins that effectively kill Pseudomonas aeruginosa in mouse models of lung and skin infection

(2019) Assaf Raz et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Aerosolized Bovine Lactoferrin Counteracts Infection, Inflammation and Iron Dysbalance in A Cystic Fibrosis Mouse Model of Pseudomonas aeruginosa Chronic Lung Infection

(2019) Antimo Cutone et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Antibacterial Properties and Efficacy of a Novel SPLUNC1-Derived Antimicrobial Peptide, α4-Short, in a Murine Model of Respiratory Infection

(2019) Shasha Jiang et al.   mBio

Vibrating Mesh Nebulisation of Pro-Antimicrobial Peptides for Use in Cystic Fibrosis

(2019) Éanna Forde et al.   Pharmaceutics

Hydrogel microspheres evading alveolar macrophages for sustained pulmonary protein delivery

(2019) Moritz Graf et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

WS01-4 Pharmacokinetics and pharmacodynamics of murepavadin (POL7080) in neutropenic lung infection models when evaluated by aerosol administration

(2019) F. Bernardini et al.   Journal of Cystic Fibrosis

Therapeutic Synergy Between Antibiotics and Pulmonary Toll-Like Receptor 5 Stimulation in Antibiotic-Sensitive or -Resistant Pneumonia

(2019) Laura Matarazzo et al.   Frontiers in Immunology

Colistin for pneumonia involving multidrug-resistant Acinetobacter calcoaceticus-Acinetobacter baumannii complex

(2019) Jun-Yuan Zheng et al.   JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION

Effect of Particle Formation Process on Characteristics and Aerosol Performance of Respirable Protein Powders

(2019) Ashlee D. Brunaugh et al.   MOLECULAR PHARMACEUTICS

Structural analysis and mode of action of BMAP-27, a cathelicidin-derived antimicrobial peptide

(2019) Sungtae Yang et al.   PEPTIDES

Nanosystems as Vehicles for the Delivery of Antimicrobial Peptides (AMPs)

(2019) Ángela Martin-Serrano et al.   Pharmaceutics

An antimicrobial molecule mitigates signs of sepsis in vivo and eradicates infections from lung tissue

(2019) Leila Quercini et al.   FASEB JOURNAL

Inhalable liposomal powder formulations for co-delivery of synergistic ciprofloxacin and colistin against multi-drug resistant gram-negative lung infections

(2019) Shihui Yu et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Assessment of colistimethate sodium (COLOBREATHE) risk minimization measures implemented in the European Union: A cross‐sectional study

(2019) Sigal Kaplan et al.   PHARMACOEPIDEMIOLOGY AND DRUG SAFETY

In vitro inhalation cytotoxicity testing of therapeutic nanosystems for pulmonary infection

(2019) Detlef Ritter et al.   TOXICOLOGY IN VITRO

Inhalable Levofloxacin Liposomes Complemented with Lysozyme for Treatment of Pulmonary Infection in Rats: Effective Antimicrobial and Antibiofilm Strategy

(2018) Purnima V. Gupta et al.   AAPS PHARMSCITECH

Influence of Formulation Factors on the Aerosol Performance and Stability of Lysozyme Powders: a Systematic Approach

(2018) Silvia Ferrati et al.   AAPS PHARMSCITECH

Enhanced efficacy of the engineered antimicrobial peptide WLBU2 via direct airway delivery in a murine model of Pseudomonas aeruginosa pneumonia

(2018) C. Chen et al.   CLINICAL MICROBIOLOGY AND INFECTION

Murepavadin: a new antibiotic class in the pipeline

(2018) Ignacio Martin-Loeches et al.   Expert Review of Anti-Infective Therapy

Dry-powder formulations of non-covalent protein complexes with linear or miktoarm copolymers for pulmonary delivery

(2018) Alejandro Nieto-Orellana et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Innate Immunity of the Lung: From Basic Mechanisms to Translational Medicine

(2018) Dominik Hartl et al.   Journal of Innate Immunity

Eradication of persistent methicillin-resistant Staphylococcus aureus infection in cystic fibrosis

(2018) Rebecca Dezube et al.   Journal of Cystic Fibrosis

Formulation of High-Performance Dry Powder Aerosols for Pulmonary Protein Delivery

(2018) Erin M. Wilson et al.   PHARMACEUTICAL RESEARCH

Characterization of Host Responses during Pseudomonas aeruginosa Acute Infection in the Lungs and Blood and after Treatment with the Synthetic Immunomodulatory Peptide IDR-1002

(2018) Kelli Wuerth et al.   INFECTION AND IMMUNITY

A novel derivative of the fungal antimicrobial peptide plectasin is active against Mycobacterium tuberculosis

(2018) Erik Tenland et al.   TUBERCULOSIS

Host Directed Therapy for Chronic Tuberculosis via Intrapulmonary Delivery of Aerosolized Peptide Inhibitors Targeting the IL-10-STAT3 Pathway

(2018) Rashmi Upadhyay et al.   Scientific Reports

Characteristics of bovine lactoferrin powders produced through spray and freeze drying processes

(2017) Bo Wang et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Investigation of factors affecting the stability of lysozyme spray dried from ethanol-water solutions

(2017) Shuying Ji et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Pharmacokinetics of nebulized colistin methanesulfonate in critically ill patients

(2017) Matthieu Boisson et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

D-BMAP18 Antimicrobial Peptide Is Active In vitro, Resists to Pulmonary Proteases but Loses Its Activity in a Murine Model of Pseudomonas aeruginosa Lung Infection

(2017) Mario Mardirossian et al.   Frontiers in Chemistry

The anti-microbial peptide TP359 attenuates inflammation in human lung cells infected with Pseudomonas aeruginosa via TLR5 and MAPK pathways

(2017) Ejovwoke F. Dosunmu et al.   PLoS One

Synthetic host defense peptide IDR-1002 reduces inflammation in Pseudomonas aeruginosa lung infection

(2017) Kelli C. Wuerth et al.   PLoS One

In vitro and in vivo evaluation of BMAP-derived peptides for the treatment of cystic fibrosis-related pulmonary infections

(2016) Mario Mardirossian et al.   AMINO ACIDS

DifferentialIn VitroandIn VivoToxicities of Antimicrobial Peptide Prodrugs for Potential Use in Cystic Fibrosis

(2016) Éanna Forde et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Efficacy of the Novel Antibiotic POL7001 in Preclinical Models of Pseudomonas aeruginosa Pneumonia

(2016) Cristina Cigana et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Pharmacokinetics/Pharmacodynamics of Pulmonary Delivery of Colistin against Pseudomonas aeruginosa in a Mouse Lung Infection Model

(2016) Yu-Wei Lin et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Substantial Targeting Advantage Achieved by Pulmonary Administration of Colistin Methanesulfonate in a Large-Animal Model

(2016) Cornelia B. Landersdorfer et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Discovery, characterization and in vivo activity of pyocin SD2, a protein antibiotic from Pseudomonas aeruginosa

(2016) L. C. McCaughey et al.   BIOCHEMICAL JOURNAL

Structural Features Essential to the Antimicrobial Functions of Human SPLUNC1

(2016) William G. Walton et al.   BIOCHEMISTRY

Stability and efficacy of synthetic cationic antimicrobial peptides nebulized using high frequency acoustic waves

(2016) Ying Wang et al.   Biomicrofluidics

Novel cationic peptide TP359 down-regulates the expression of outer membrane biogenesis genes in Pseudomonas aeruginosa: a potential TP359 anti-microbial mechanism

(2016) Ejovwoke F. Dosunmu et al.   BMC MICROBIOLOGY

Investigation of the enhanced antimicrobial activity of combination dry powder inhaler formulations of lactoferrin

(2016) Lindsay J. Marshall et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Combinations of colistin solutions and nebulisers for lung infection management in cystic fibrosis patients

(2016) Francesca Buttini et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Determination of Colistin and Colistimethate Levels in Human Plasma and Urine by High-Performance Liquid Chromatography–Tandem Mass Spectrometry

(2016) Kevin Bihan et al.   THERAPEUTIC DRUG MONITORING

Surfactant Protein-D Is Essential for Immunity to Helminth Infection

(2016) Sumaiyya Thawer et al.   PLoS Pathogens

Pseudomonas aeruginosainfection in cystic fibrosis: pathophysiological mechanisms and therapeutic approaches

(2016) Helena Lund-Palau et al.   Expert Review of Respiratory Medicine

Inhaled formulations and pulmonary drug delivery systems for respiratory infections

(2015) Qi (Tony) Zhou et al.   ADVANCED DRUG DELIVERY REVIEWS

Protein stability in pulmonary drug delivery via nebulization

(2015) Sebastian P. Hertel et al.   ADVANCED DRUG DELIVERY REVIEWS

Pulmonary Delivery of Vancomycin Dry Powder Aerosol to Intubated Rabbits

(2015) Bradley P. Sullivan et al.   MOLECULAR PHARMACEUTICS

APD3: the antimicrobial peptide database as a tool for research and education

(2015) Guangshun Wang et al.   NUCLEIC ACIDS RESEARCH

Pharmacokinetics of Colistin Methansulphonate (CMS) and Colistin after CMS Nebulisation in Baboon Monkeys

(2015) Sandrine Marchand et al.   PHARMACEUTICAL RESEARCH

Comparison of Intrapulmonary and Systemic Pharmacokinetics of Colistin Methanesulfonate (CMS) and Colistin after Aerosol Delivery and Intravenous Administration of CMS in Critically Ill Patients

(2014) Matthieu Boisson et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Pulmonary and Systemic Pharmacokinetics of Inhaled and Intravenous Colistin Methanesulfonate in Cystic Fibrosis Patients: Targeting Advantage of Inhalational Administration

(2014) S. W. S. Yapa et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Combination of hypothiocyanite and lactoferrin (ALX-109) enhances the ability of tobramycin and aztreonam to eliminate Pseudomonas aeruginosa biofilms growing on cystic fibrosis airway epithelial cells

(2014) S. Moreau-Marquis et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Cathelicidin Host Defence Peptide Augments Clearance of Pulmonary Pseudomonas aeruginosa Infection by Its Influence on Neutrophil Function In Vivo

(2014) Paula E. Beaumont et al.   PLoS One

Targeting Inhaled Therapy beyond the Lungs

(2014) Ninell P. Mortensen et al.   RESPIRATION

Optimization of nebulized delivery of linezolid, daptomycin, and vancomycin aerosol

(2014) Paul Zarogoulidis et al.   Drug Design Development and Therapy

Potential of Host Defense Peptide Prodrugs as Neutrophil Elastase-Dependent Anti-Infective Agents for Cystic Fibrosis

(2013) Éanna Forde et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Population Pharmacokinetics of Colistin Methanesulfonate in Rats: Achieving Sustained Lung Concentrations of Colistin for Targeting Respiratory Infections

(2013) Shalini W. S. Yapa et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Advanced spray-dried design, physicochemical characterization, and aerosol dispersion performance of vancomycin and clarithromycin multifunctional controlled release particles for targeted respiratory delivery as dry powder inhalation aerosols

(2013) Chun-Woong Park et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Characterization and Application of a Nose-Only Exposure Chamber for Inhalation Delivery of Liposomal Drugs and Nucleic Acids to Mice

(2013) G. Mainelis et al.   Journal of Aerosol Medicine and Pulmonary Drug Delivery

Delivery of the endolysin Cpl-1 by inhalation rescues mice with fatal pneumococcal pneumonia

(2013) J. M. Doehn et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

The Future of Antibiotics and Resistance

(2013) Brad Spellberg et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ability of Innate Defence Regulator Peptides IDR-1002, IDR-HH2 and IDR-1018 to Protect against Mycobacterium tuberculosis Infections in Animal Models

(2013) Bruno Rivas-Santiago et al.   PLoS One

STAT3 suppresses transcription of proapoptotic genes in cancer cells with the involvement of its N-terminal domain

(2013) Olga A. Timofeeva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Efficacy of High-dose Nebulized Colistin in Ventilator-associated Pneumonia Caused by Multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii

(2012) Qin Lu et al.   ANESTHESIOLOGY

Potential novel therapeutic strategies in cystic fibrosis: antimicrobial and anti-biofilm activity of natural and designed α-helical peptides against Staphylococcus aureus, Pseudomonas aeruginosa, and Stenotrophomonas maltophilia

(2012) Arianna Pompilio et al.   BMC MICROBIOLOGY

Pharmacokinetics of inhaled colistimethate sodium (CMS) in mechanically ventilated critically ill patients

(2012) Zoe E. Athanassa et al.   INTENSIVE CARE MEDICINE

Interaction of Colistin and Colistin Methanesulfonate with Liposomes: Colloidal Aspects and Implications for Formulation

(2012) Stephanie J. Wallace et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Reduced airway surface pH impairs bacterial killing in the porcine cystic fibrosis lung

(2012) Alejandro A. Pezzulo et al.   NATURE

Aerosolized recombinant human lysozyme enhances the bactericidal effect of tobramycin in a hamster model ofpseudomonas aeruginosa–induced pneumonia

(2011) Tapan Bhavsar et al.   EXPERIMENTAL LUNG RESEARCH

Local Delivery of GM-CSF Protects Mice from Lethal Pneumococcal Pneumonia

(2011) Kathrin Steinwede et al.   JOURNAL OF IMMUNOLOGY

Mannitol Delivery by Vibrating Mesh Nebulisation for Enhancing Mucociliary Clearance

(2011) John Gar Yan Chan et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

The role of IL-10 in immune regulation during M. tuberculosis infection

(2011) P S Redford et al.   Mucosal Immunology

Antibacterial and anti-biofilm effects of cathelicidin peptides against pathogens isolated from cystic fibrosis patients

(2011) A. Pompilio et al.   PEPTIDES

Aerosol Therapy with Colistin Methanesulfonate: a Biopharmaceutical Issue Illustrated in Rats

(2010) S. Marchand et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Chronic colonization by Pseudomonas aeruginosa of patients with obstructive lung diseases: cystic fibrosis, bronchiectasis, and chronic obstructive pulmonary disease

(2010) Andrea D. Valderrey et al.   DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE

Carrier mediated protein and peptide stabilization

(2010) Amit Kumar Tiwari et al.   DRUG DELIVERY

Nebulized and intravenous colistin in experimental pneumonia caused by Pseudomonas aeruginosa

(2010) Qin Lu et al.   INTENSIVE CARE MEDICINE

Randomized controlled trial of nebulized colistimethate sodium as adjunctive therapy of ventilator-associated pneumonia caused by Gram-negative bacteria

(2010) P. Rattanaumpawan et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Flagellin Stimulates Protective Lung Mucosal Immunity: Role of Cathelicidin-Related Antimicrobial Peptide

(2010) F.-s. Yu et al.   JOURNAL OF IMMUNOLOGY

Synthetic Cationic Peptide IDR-1002 Provides Protection against Bacterial Infections through Chemokine Induction and Enhanced Leukocyte Recruitment

(2010) Anastasia Nijnik et al.   JOURNAL OF IMMUNOLOGY

Peptidomimetic Antibiotics Target Outer-Membrane Biogenesis in Pseudomonas aeruginosa

(2010) N. Srinivas et al.   SCIENCE

Proteolysis of Peptide Dendrimers

(2009) Peter Sommer et al.   CHEMBIOCHEM

A novel tetrabranched antimicrobial peptide that neutralizes bacterial lipopolysaccharide and prevents septic shock in vivo

(2009) Alessandro Pini et al.   FASEB JOURNAL

Miniature inhalation therapy platform using surface acoustic wave microfluidic atomization

(2009) Aisha Qi et al.   LAB ON A CHIP

Therapeutic effects of recombinant forms of full-length and truncated human surfactant protein D in a murine model of invasive pulmonary aspergillosis

(2009) Mamta Singh et al.   MOLECULAR IMMUNOLOGY

Aerosolized vancomycin for the treatment of MRSA after lung transplantation

(2009) Don HAYES JR et al.   RESPIROLOGY