Article
Microbiology
Marco Falcone, Giusy Tiseo, Alessandro Leonildi, Leonardo Della Sala, Alessandra Vecchione, Simona Barnini, Alessio Farcomeni, Francesco Menichetti
Summary: Cefiderocol appears to be a promising therapeutic option for carbapenem-resistant Acinetobacter baumannii (CRAB) infections, with a potential protective effect on 30-day mortality. However, further studies are needed to address the issue of microbiological failure.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Microbiology
Jiaqi Cheng, Jun Yan, Zeferino Reyna, Matt Slarve, Peggy Lu, Brad Spellberg, Brian Luna
Summary: The study found that rifabutin and colistin showed synergistic effects in combating Acinetobacter baumannii, with low-dose colistin significantly suppressing the emergence of rifabutin resistance. This combination presents a promising therapeutic option for highly resistant A. baumannii infections.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Infectious Diseases
Zhiren Wang, Xuanyang Fan, Shuyi Wang, Shuguang Li, Yue Gao, Hui Wang, Henan Li
Summary: The increasing number of multidrug-resistant Gram-negative bacteria poses a serious threat to global health. In this study, a colistin-resistant Acinetobacter junii isolate, AJ6079, was identified in a clinical blood sample. The isolate exhibited a dry phenotype and had a thick outer membrane. Comparative genomic analysis revealed several previously unreported point mutations in colistin-resistance-related genes, potentially correlated with colistin resistance in A. junii. Further research is needed to verify these findings.
Article
Infectious Diseases
Alzbeta Kalova, Tereza Gelbicova, Soren Overballe-Petersen, Eva Litrup, Renata Karpiskova
Summary: This study characterized bacterial strains resistant to colistin in retailed aquaculture products imported from Vietnam to the Czech Republic, with some strains carrying multiple mcr genes on various plasmids. The results suggest that aquaculture products of Asian origin can be an important source of variable plasmids carrying mcr genes.
Article
Biochemistry & Molecular Biology
Jovana Kabic, Katarina Novovic, Dusan Kekic, Anika Trudic, Natasa Opavski, Ivica Dimkic, Branko Jovcic, Ina Gajic
Summary: This study aimed to investigate the prevalence and resistance mechanisms of colistin-resistant Acinetobacter baumannii (ColRAB) isolates in Serbia, assess their genetic relatedness to other circulating A. baumannii isolates in the neighbouring European countries, and analyse the global genomic epidemiology of ColRAB isolates. The findings reveal the central role of the twocomponent regulating system, PmrAB, and increased expression of the pmrC gene in colistin resistance in A. baumannii. The study also highlights the global dissemination of several high-risk clonal lineages of ColRAB isolates.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Article
Infectious Diseases
Gennaro De Pascale, Gabriele Pintaudi, Lucia Lisi, Flavio De Maio, Salvatore Lucio Cutuli, Eloisa Sofia Tanzarella, Simone Carelli, Gianmarco Lombardi, Melania Cesarano, Veronica Gennenzi, Gabriella Maria Pia Ciotti, Domenico Luca Grieco, Brunella Posteraro, Maurizio Sanguinetti, Pierluigi Navarra, Massimo Antonelli
Summary: This study investigated the clinical use of high-dose aerosolized colistin for COS-AB VAP patients in the ICU. The results showed that this strategy was safe and effective, but its specific role and efficacy in this setting still need further investigation.
Article
Immunology
Ya-Sung Yang, Wen-Yih Jeng, Yi-Tzu Lee, Chi-Ju Hsu, Yu-Ching Chou, Shu-Chen Kuo, Cheng-Cheung Chen, Wei-Jane Hsu, Hsing-Yu Chen, Jun-Ren Sun
Summary: This study investigated the mechanisms underlying colistin resistance in clinical ColRAN isolates, identifying a key amino acid Ser253Leu in PmrB associated with overexpression of the pmrCAB operon and colistin resistance. The results provide insight into the mechanism of colistin resistance in A. nosocomialis, contributing to better understanding of antibiotic resistance in nosocomial infections.
EMERGING MICROBES & INFECTIONS
(2021)
Article
Multidisciplinary Sciences
Nayara Helisandra Fedrigo, Danielle Rosani Shinohara, Josmar Mazucheli, Sheila Alexandra Belini Nishiyama, Floristher Elaine Carrara-Marroni, Frederico Severino Martins, Peijuan Zhu, Mingming Yu, Sherwin Kenneth B. Sy, Maria Cristina Bronharo Tognim
Summary: The study showed that the combination of polymyxin B with meropenem and fosfomycin was effective in inhibiting A. baumannii strains belonging to clonal lineages I and III, reducing resistance and mutant selection window. By combining polymyxin B with other drugs, the therapeutic effect can be enhanced.
SCIENTIFIC REPORTS
(2021)
Article
Infectious Diseases
Ye Tao, Sebastien Acket, Emma Beaumont, Henri Galez, Luminita Duma, Yannick Rossez
Summary: The study conducted a detailed analysis of the lipidomics of multidrug-resistant Acinetobacter baumannii, revealing significant changes in lipid content in susceptible and resistant strains at colistin concentrations, highlighting the plasma membrane plasticity used by this gram-negative bacterium to cope with colistin treatment.
Article
Infectious Diseases
Yun-Jeong Jeong, Namyi Gu, Won Gun Kwack, Yunseong Kang, Seong Yeon Park, Young-Soon Yoon
Summary: This study investigated the importance of predicting nephrotoxicity in patients with CRAB pneumonia. The results showed that plasma levels of CMS and colistin, especially maximum levels, are crucial for predicting nephrotoxicity in these patients.
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2021)
Article
Immunology
Xiaoqing Wang, Belinda Loh, Fernando Gordillo Altamirano, Yunsong Yu, Xiaoting Hua, Sebastian Leptihn
Summary: Multidrug-resistant bacterial infections are on the rise, leading to the search for new therapeutic approaches. Phage therapy is gaining attention as an alternative treatment strategy, but faces the challenge of phage-resistant bacteria. This study aims to understand the mechanisms of phage resistance in Acinetobacter baumannii and identifies potential strategies that could be exploited in clinical settings.
EMERGING MICROBES & INFECTIONS
(2021)
Article
Microbiology
Hadas Kon, Amichay Hameir, Elizabeth Temkin, Alona Keren-Paz, David Schwartz, Vered Schechner, Yehuda Carmeli
Summary: This study aimed to investigate the emergence of colistin-dependent (CD) strains in carbapenem-resistant Acinetobacter baumannii (CRAB) isolates with colistin heteroresistance, and to examine the phenotypic characteristics and evolution of CD strains. The study also found that CD strains exhibited increased susceptibilities to multiple antibiotics, but the detection of CD strains in blood cultures was significantly delayed.
Article
Infectious Diseases
Chutchawan Ungthammakhun, Vasin Vasikasin, Dhitiwat Changpradub
Summary: Extensively drug-resistant A. baumannii (XDRAB) pneumonia has a high mortality rate. This study compared the efficacy of combination treatment with colistin and sulbactam at a dosage of either 9 g/day or 12 g/day. The results did not show superiority of the 12 g/day dosage over the 9 g/day dosage. However, this trial was underpowered to detect mortality differences due to being an interim analysis.
Article
Infectious Diseases
Dalia Adukauskiene, Ausra Ciginskiene, Agne Adukauskaite, Despoina Koulenti, Jordi Rello
Summary: This study compared the clinical features and mortality of monobacterial and polybacterial multidrug-resistant A. baumannii hospital-acquired pneumonia. The results showed that monobacterial episodes had higher 30-day mortality and different risk factors.
Article
Microbiology
Amy K. Cain, Mehrad Hamidian
Summary: Antibiotic resistance is a growing global concern, especially in the case of Acinetobacter baumannii, a highly antibiotic-resistant pathogen causing various infections. The global spread of antibiotic-resistant strains of A. baumannii has led to limited treatment options, increased morbidity and mortality rates, longer hospital stays, and higher healthcare costs. A. baumannii employs clever strategies such as horizontal gene transfer, overexpression of efflux pumps, mutations, and natural selection to develop antibiotic resistance, making infections caused by this pathogen challenging to control and treat. Addressing this problem requires increased surveillance, strict infection control measures, and the development of new treatment strategies through collaboration among healthcare professionals, researchers, and policymakers.